中国现代神经疾病杂志 ›› 2025, Vol. 25 ›› Issue (1): 57-64. doi: 10.3969/j.issn.1672-6731.2025.01.008

• 神经调控技术应用与进展 • 上一篇    下一篇

2 精神疾病神经调控治疗进展

董文文, 邱畅, 赵亮, 章文斌*()   

  1. 210029 南京医科大学附属脑科医院功能神经外科
  • 收稿日期:2024-12-03 出版日期:2025-01-25 发布日期:2025-02-10
  • 通讯作者: 章文斌
  • 基金资助:
    江苏省重点研发计划产业前瞻与关键技术研发项目(BE2022049); 江苏省重点研发计划产业前瞻与关键技术研发项目(BE2022049-1)

Progress on neuromodulation for treatment of mental disorders

Wen-wen DONG, Chang QIU, Liang ZHAO, Wen-bin ZHANG*()   

  1. Department of Functional Neurosurgery, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China
  • Received:2024-12-03 Online:2025-01-25 Published:2025-02-10
  • Contact: Wen-bin ZHANG
  • Supported by:
    Key Research and Development Program of Jiangsu Science and Technology Project(BE2022049); Key Research and Development Program of Jiangsu Science and Technology Project(BE2022049-1)

摘要:

精神疾病传统治疗方法包括药物治疗和心理治疗,但部分患者无法有效控制症状。神经调控技术主要分为侵入性或非侵入性,对神经回路进行干预可改善精神疾病患者精神症状。本文对强迫症、抑郁症、抽动秽语综合征、双相情感障碍、孤独症谱系障碍、物质依赖及精神分裂症等精神疾病所用神经调控技术的应用现状进行总结,并分析神经调控技术在精神疾病治疗中的前景及挑战,以指导未来精神疾病的神经调控治疗。

关键词: 精神障碍, 物理刺激, 经颅磁刺激, 深部脑刺激法, 综述

Abstract:

Traditional treatment methods for mental disorders include pharmacotherapy and psychotherapy. However, some patients are unable to effectively control their symptoms. Neuromodulation technique, which can be implemented through invasive or non-invasive approaches, have shown promise in improving the psychiatric symptoms of individuals with mental illnesses by intervening in neural circuits. This paper summarizes the current applications of neuromodulation technique for various mental disorders, including obsessive-compulsive disorder, depression, Tourette's syndrome, bipolar affective disorder, autism spectrum disorder, substance dependence and schizophrenia. Additionally, it analyzes the prospects and challenges of neuromodulation technique in the treatment of mental disorders, with the aim of guiding future neuromodulation therapy for mental disorders.

Key words: Mental disorders, Physical stimulation, Transcranial magnetic stimulation, Deep brain stimulation, Review