中国现代神经疾病杂志 ›› 2025, Vol. 25 ›› Issue (1): 41-47. doi: 10.3969/j.issn.1672-6731.2025.01.006

• 神经调控技术应用与进展 • 上一篇    下一篇

2 罕见运动障碍疾病神经调控治疗进展

董文文1, 邱畅1, 徐怿琛2, 杨岸超2,3,*(), 章文斌1,*()   

  1. 1. 210029 南京医科大学附属脑科医院功能神经外科
    2. 100070 首都医科大学附属北京天坛医院神经外科学中心 首都医科大学北京市神经外科研究所 神经电刺激研究与治疗北京市重点实验室
    3. 100084 北京, 神经调控国家工程研究中心
  • 收稿日期:2024-12-09 出版日期:2025-01-25 发布日期:2025-02-10
  • 通讯作者: 杨岸超, 章文斌
  • 基金资助:
    江苏省重点研发计划产业前瞻与关键技术研发项目(BE2022049); 江苏省重点研发计划产业前瞻与关键技术研发项目(BE2022049-1)

Progress on neuromodulation for treatment of rare movement disorders

Wen-wen DONG1, Chang QIU1, Yi-chen XU2, An-chao YANG2,3,*(), Wen-bin ZHANG1,*()   

  1. 1. Department of Functional Neurosurgery, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China
    2. Center of Neurosurgery, Beijing Tiantan Hospital; Beijing Neurosurgical Institute; Beijing Key Laboratory of Neurostimulation, Capital Medical University, Beijing 100070, China
    3. National Engineering Research Center for Neuromodulation, Beijing 100084, China
  • Received:2024-12-09 Online:2025-01-25 Published:2025-02-10
  • Contact: An-chao YANG, Wen-bin ZHANG
  • Supported by:
    Key Research and Development Program of Jiangsu Science and Technoloyg Project(BE2022049); Key Research and Development Program of Jiangsu Science and Technoloyg Project(BE2022049-1)

摘要:

罕见运动障碍疾病的传统药物治疗效果有限,而脑深部电刺激术、脊髓电刺激术,以及经颅磁刺激、经颅直流电刺激和电休克疗法等神经调控技术的兴起为罕见运动障碍疾病的治疗带来新的希望。本文系统回顾并总结上述侵入性和非侵入性神经调控技术在脊髓小脑性共济失调、亨廷顿病、神经棘红细胞增多症等多种罕见运动障碍疾病中的应用及疗效,以为神经调控技术在罕见运动障碍疾病中的应用提供指导。

关键词: 动作障碍, 电刺激疗法, 物理刺激, 经颅磁刺激, 综述

Abstract:

Traditional pharmacological treatments for rare movement disorders have limited efficacy. However, the emergence of neuromodulation technique such as deep brain stimulation (DBS), spinal cord stimulation (SCS), transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS) and electroconvulsive therapy (ECT) offers new hope for patients with rare movement disorders. This review systematically summarizes the application and efficacy of both invasived and non-invasived neuromodulation techniques in treating various rare movement disorders, including spinocerebellar ataxia (SCA), Huntington's disease (HD), and neuroacanthocytosis (NA), etc.. The aim is to provide guidance for the application of neuromodulation technique in rare movement disorders.

Key words: Movement disorders, Electric stimulation therapy, Physical stimulation, Transcranial magnetic stimulation, Review