中国现代神经疾病杂志 ›› 2017, Vol. 17 ›› Issue (8): 561-565. doi: 10.3969/j.issn.1672-6731.2017.08.002

• 专题综述 • 上一篇    下一篇

2 特发性震颤研究进展

徐恬, 赵国华   

  1. 322000 义乌,浙江大学医学院附属第四医院神经内科(徐恬);310009 杭州,浙江大学医学院附属第二医院神经内科(赵国华)
  • 出版日期:2017-08-25 发布日期:2017-08-25
  • 通讯作者: 赵国华(Email:zhaoguohuazq@hotmail.com)
  • 基金资助:

    浙江省医药卫生研究计划(项目编号:2016KYB118)

Research on advances of essential tremor

XU Tian1, ZHAO Guo-hua2   

  1. 1Department of Neurology, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, Zhejiang, China
    2Department of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang, China
  • Online:2017-08-25 Published:2017-08-25
  • Contact: ZHAO Guo-hua (Email: zhaoguohuazq@hotmail.com)
  • Supported by:

    This study was supported by Medical and Health Research Program of Zhejiang Province, China (No. 2016KYB118).

摘要:

特发性震颤除表现为震颤外,还可以出现共济失调等运动症状以及认知功能障碍、情感障碍和听力下降等非运动症状。发病机制尚不明确,小脑、脑干、红核、丘脑和基底神经核均受累,致病基因的克隆为发病机制的研究奠定基础。治疗方法主要包括药物治疗和外科手术,其中,表现为头部、手部和声音震颤的患者可肌肉注射A 型肉毒毒素,外科手术包括丘脑毁损术和脑深部电刺激术等。

关键词: 特发性震颤, 综述

Abstract:

Recent research shows besides the symptom of tremor, essential tremor (ET) patients also present with motor symptoms such as dysfunction of cerebellum, and non?motor symptoms (NMS) such as cognitive impairment, mood symptoms and loss of hearing. The mechanism of ET remains unclear. The dysfunction of cerebellum, brain stem, red nuclei, thalamus and basal nuclei could be involved in ET. Several loci and genes were identified, which is helpful for the study of mechanism on ET. The therapies of ET include medication and surgery. The botulinum toxin A could be used in the ET patients whose main symptoms are tremor of head, hand and voice. The surgeries include thalamotomy and deep brain stimulation (DBS).

Key words: Essential tremor, Review