5-羟色胺与帕金森病非运动症状研究进展

doi:10.3969/j.issn.1672-6731.2024.06.013

中国现代神经疾病杂志 ›› 2024, Vol. 24 ›› Issue (6): 497-501. doi: 10.3969/j.issn.1672-6731.2024.06.013

2 5-羟色胺与帕金森病非运动症状研究进展

史若琳¹, 高秀洁², 崔家宁¹, 邵妍³, 谢璐霜⁴, 刘毅¹^,*()

1. 116033 大连理工大学附属中心医院神经内科
2. 116033 大连医科大学放射影像学院2022级
3. 118000 辽宁省丹东市中心医院神经内科
4. 610075 成都中医药大学基础医学院

收稿日期:2023-11-09 出版日期:2024-06-25 发布日期:2024-07-05
通讯作者: 刘毅
基金资助:
国家自然科学基金资助项目(82174511); 辽宁省“兴辽英才计划”项目(XLYC1807083); 辽宁省大连市科技创新惠民计划项目(2021JJ13SN64); 辽宁省大连市生命健康领域指导计划项目(2022ZXYG31); 辽宁省大连市中心医院“登峰计划”项目(2023ZZ010)

Advance on association between 5-hydroxytryptamine and non-motor symptoms in Parkinson's disease

Ruo-lin SHI¹, Xiu-jie GAO², Jia-ning CUI¹, Yan SHAO³, Lu-shuang XIE⁴, Yi LIU¹^,*()

1. Department of Neurology, Central Hospital of Dalian University of Technology, Dalian 116033, Liaoning, China
2. Grade 2022, Discipline of Radiology, Dalian Medical University, Dalian 116033, Liaoning, China
3. Department of Neurology, Dandong Central Hospital, Dandong 118000, Liaoning, China
4. College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China

Received:2023-11-09 Online:2024-06-25 Published:2024-07-05
Contact: Yi LIU
Supported by:
the National Natural Science Foundation of China(82174511); Liaoning "Xingliao Talents Plan" Project(XLYC1807083); Dalian Science and Technology Innovation Benefits the People Plan in Liaoning(2021JJ13SN64); Dalian Life Health Area Guidence Program in Liaoning(2022ZXYG31); Science and Technology Program of Dalian Central Hospital "Peak Climbing Program" in Liaoning(2023ZZ010)

摘要/Abstract

摘要：

帕金森病是临床常见的神经系统变性疾病，通常伴有胃肠功能障碍、嗅觉减退、睡眠障碍、抑郁、疼痛和幻觉等非运动症状，严重降低患者生活质量。帕金森病患者存在5-羟色胺能神经元退行性变等非多巴胺能系统弥漫性病理改变，且5-羟色胺在情绪、认知功能、疼痛等多种神经功能调节方面发挥重要作用，与帕金森病非运动症状密切相关。本文综述5-羟色胺与帕金森病非运动症状之间的相关性及其研究进展，以明确帕金森病非运动症状的发病机制，为实现疾病的早期诊断与精准治疗提供理论基础。

关键词: 帕金森病, 血清素, 综述

Abstract:

Parkinson's disease (PD) is a common neurodegenerative disease in clinical practice. Patients with PD are usually accompanied by non-motor symptoms (NMS) such as gastrointestinal dysfunction, hyposmia, sleep disorders, depression, pain and hallucinations, which seriously reduce the quality of life. Recent studies have found that PD patients were accompanied by diffuse pathological changes in non-dopaminergic system such as progressive degeneration of 5 -hydroxytryptamine (5-HT) ergic neurons, and 5-HT plays an important role in the regulation of emotion, cognitive function, pain and other neural functions, and is closely related to non-motor symptoms of PD. This article reviews the correlation between 5-HT and non-motor symptoms of PD and its research progress, in order to further clarify the pathogenesis of non-motor symptoms of PD and provide a theoretical basis for the treatment of PD.

Key words: Parkinson disease, Serotonin, Review

史若琳, 高秀洁, 崔家宁, 邵妍, 谢璐霜, 刘毅. 5-羟色胺与帕金森病非运动症状研究进展[J]. 中国现代神经疾病杂志, 2024, 24(6): 497-501.

Ruo-lin SHI, Xiu-jie GAO, Jia-ning CUI, Yan SHAO, Lu-shuang XIE, Yi LIU. Advance on association between 5-hydroxytryptamine and non-motor symptoms in Parkinson's disease[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(6): 497-501.

https://journal11.magtechjournal.com/cjcnn/CN/Y2024/V24/I6/497

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2 5-羟色胺与帕金森病非运动症状研究进展

Advance on association between 5-hydroxytryptamine and non-motor symptoms in Parkinson's disease

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