关键词: 关键词：子宫内膜异位症, 疼痛, 中枢敏化, 外周敏化, NF-kB, 炎症, 凋亡, 氧化应激, 血管生成

Abstract: Endometriosis is a benign gynecologic disease, affecting women of reproductive age associated with chronic pelvic pain. Activation of NF-?B has been implicated in the early development as well as processes of endometriosis lesions. In vitro and in vivo studies show that NF-?B mediated gene transcription promotes immune and inflammatory response, modulates cell proliferation, apoptosis, adhesion, invasion, and angiogenesis of endometriotic cells which may attribute to changes of peripheral nerves and the peritoneal environment in endometriosis lesions and cause pain. This may indicate a new target for the cure of endometriosis pain.

Key words: Key words: Endometriosis , Pain, Central sensitization, Peripheral sensitization, NF-kB , Inflammatory response , Apoptosis , Oxidative Stress , Angiogenesis