基础医学与临床 ›› 2025, Vol. 45 ›› Issue (4): 536-541.doi: 10.16352/j.issn.1001-6325.2025.04.0536

• 短篇综述 • 上一篇    下一篇

乙酰化修饰与慢性阻塞性肺疾病

王佩1, 卞涛2, 吴艳2*   

  1. 1.南京医科大学附属无锡临床医学院 呼吸内科,江苏 无锡 214000;
    2.南京医科大学附属无锡人民医院 呼吸与危重症医学科,江苏 无锡 214023
  • 收稿日期:2024-06-19 修回日期:2024-11-08 出版日期:2025-04-05 发布日期:2025-03-24
  • 通讯作者: *wuyanphd@163.com
  • 基金资助:
    国家自然科学基金(82173472)

Acetylation modification and chronic obstructive pulmonary disease

WANG Pei1, BIAN Tao2, WU Yan2*   

  1. 1. Department of Respiratory Medicine, Wuxi Clinical Medical College of Nanjing Medical University,Wuxi 214000;
    2. Department of Respiratory and Critical Care Medicine,Wuxi People's Hospital Affiliated to Nanjing Medical University,Wuxi 214023, China
  • Received:2024-06-19 Revised:2024-11-08 Online:2025-04-05 Published:2025-03-24

摘要: 慢性阻塞性肺疾病的主要特征包括慢性气道炎性反应、持续性气流受限、进行性呼吸困难和肺功能受损。乙酰化修饰是最常见的蛋白翻译后修饰方式之一,通过调节基因表达、细胞信号转导和蛋白质功能等途径,在慢性阻塞性肺疾病的发病机制如氧化应激、炎性反应、气道重塑中发挥重要作用。因此探究乙酰化修饰在慢性阻塞性肺疾病中的相关调控机制,不仅能深入理解疾病的病理生理机制,还为新治疗策略的开发提供理论基础。

关键词: 乙酰化修饰, 慢性阻塞性肺疾病, 炎性反应, 氧化应激

Abstract: The main features of chronic obstructive pulmonary disease include chronic airway inflammation, persistent airflow limitation, progressive dyspnea, and impaired lung function. Acetylation is one of the most common post-translational modifications of proteins, which plays an important role in the pathogenesis of chronic obstructive pulmonary disease, such as oxidative stress, inflammatory reaction, and airway remodeling, by regulating gene expression, cell signaling, and protein function. Therefore, exploring the regulatory mechanism of acetylating modification in chronic obstructive pulmonary disease can not only deeply understand the pathophysiological mechanism of the disease, but also provide a theoretical basis for the development of new treatment strategies.

Key words: acetylation, chronic obstructive pulmonary disease, inflammatory reaction, oxidative stress

中图分类号: