诱导抑郁症患者小胶质细胞炎性反应的机制

doi:10.16352/j.issn.1001-6325.2024.07.1029

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (7): 1029-1033.doi: 10.16352/j.issn.1001-6325.2024.07.1029

诱导抑郁症患者小胶质细胞炎性反应的机制

张昊, 孙浩, 廖红^*

中国药科大学新药筛选与药效评价中心,江苏南京 210009

收稿日期:2024-03-15 修回日期:2024-05-21 出版日期:2024-07-05 发布日期:2024-06-26
通讯作者: ^*hliao@cpu.edu.cn
基金资助:
国家自然科学基金(82073831);重庆市自然科学基金(CSTB2023NSCQ-MSX0656);中国博士后科学基金(2023M733889)

Mechanism of inducing microglial inflammatory response in patients with depression

ZHANG Hao, SUN Hao, LIAO Hong^*

New Drug Screening and Pharmacodynamics Evaluation Center, China Pharmaceutical University, Nanjing 210009, China

Received:2024-03-15 Revised:2024-05-21 Online:2024-07-05 Published:2024-06-26
Contact: ^*hliao@cpu.edu.cn

摘要/Abstract

摘要： 小胶质细胞炎性反应是抑郁症患者及相关动物模型中广泛观察到的病理现象,与抑郁症密切相关。抑郁症中诱导小胶质细胞炎性反应的机制包括下丘脑-垂体-肾上腺(HPA)轴激活后糖皮质激素水平变化直接或间接的调控作用、肠道微生物代谢物通过脑肠轴中免疫与神经途径的作用以及损伤相关分子模式(DAMPs)对小胶质细胞的直接激活作用等。

关键词: 抑郁症, 小胶质细胞炎性反应, 下丘脑-垂体-肾上腺(HPA)轴, 脑肠轴, 损伤相关分子模式(DAMPs)

Abstract: Microglial inflammatory response is a pathological process frequently found in patients with depression and in animal models, which is believed to be closely related to depression. The potential mechanisms of inducing microglial inflammatory response by depression includes the direct or indirect regulation of glucocorticoid level changes after activation of the hypothalamic-pituitary-adrenal (HPA) axis, the effect of intestinal microbial metabolites through immune and neural pathways in the brain-gut axis, and the direct activation of damage associated molecular patterns (DAMPs) in microglia.

Key words: depression, microglial inflammatory response, hypothalamic-pituitary-adrenal (HPA) axis, gut-brain axis, damage associated molecular patterns (DAMPs)

中图分类号:

R749.4

张昊, 孙浩, 廖红. 诱导抑郁症患者小胶质细胞炎性反应的机制[J]. 基础医学与临床, 2024, 44(7): 1029-1033.

ZHANG Hao, SUN Hao, LIAO Hong. Mechanism of inducing microglial inflammatory response in patients with depression[J]. Basic & Clinical Medicine, 2024, 44(7): 1029-1033.

参考文献

[1]Du Preez A, Onorato D, Eiben I, et al. Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in male mice[J]. Brain Behav Immun, 2021, 91: 24-47. doi:10.1016/j.bbi.2020.07.015.
[2]Picard K, Bisht K, Poggini S, et al. Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice[J]. Brain Behav Immun, 2021, 97: 423-439. doi:10.1016/j.bbi.2021.07.022.
[3]Tret′yakova LV, Kvichansky AA, Barkovskaya ES, et al. Ambiguous contribution of glucocorticosteroids to acute neuroinflammation in the hippocampus of rat[J]. Int J Mol Sci, 2023, 24: 11147. doi:10.3390/ijms241311147.
[4]Tapp ZM, Godbout JP, Kokiko-Cochran ON. A tilted axis: maladaptive inflammation and HPA axis dysfunction contribute to consequences of TBI[J]. Front Neurol, 2019, 10: 345. doi:10.3389/fneur.2019.00345.
[5]Frank MG, Hershman SA, Weber MD, et al. Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus[J]. Psychoneuroendocrinology, 2014, 40: 191-200. doi:10.1016/j.psyneuen.2013.11.006.
[6]He H, Xie X, Zhang J, et al. Patchouli alcohol amelior-ates depression-like behaviors through inhibiting NLRP3-mediated neuroinflammation in male stress-exposed mice[J]. J Affect Disord, 2023, 326: 120-131. doi:10.1016/j.jad.2023.01.065.
[7]Hartmann J, Bajaj T, Klengel C, et al. Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5[J]. Cell Rep, 2021, 35: 109185. doi:10.1016/j.celrep.2021.109185.
[8]Almeida SS, Oliveira MA, Medeiros R, et al. Emotional, inflammatory, and genetic factors of resilience and vulnerability to depression in patients with premenopausal breast cancer: a longitudinal study protocol[J]. PLoS One, 2023, 18: e0279344. doi:10.1371/journal.pone.0279344.
[9]Huang Y, Wu J, Zhang H, et al. The gut microbiome modulates the transformation of microglial subtypes[J]. Mol Psychiatry, 2023, 28: 1611-1621. doi:10.1038/s41380-023-02017-y.
[10]Wu Q, Zhang Y, Zhang Y, et al. Potential effects of antibiotic-induced gut microbiome alteration on blood-brain barrier permeability compromise in rhesus monkeys[J]. Ann N Y Acad Sci, 2020, 1470: 14-24. doi:10.1111/nyas.14312.
[11]Mossad O, Batut B, Yilmaz B, et al. Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine[J]. Nat Neurosci, 2022, 25: 295-305. doi:10.1038/s41593-022-01027-3.
[12]Shi H, Ge X, Ma X, et al. A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites[J]. Microbiome, 2021, 9: 223. doi:10.1186/s40168-021-01172-0.
[13]Zu X, Xin J, Xie H, et al. Characteristics of gut microbiota and metabolic phenotype in patients with major depressive disorder based on multi-omics analysis[J]. J Affect Disord, 2024, 344: 563-576. doi:10.1016/j.jad.2023.10.104.
[14]Schreiber LS, Wozniak D, Scheller E, et al. Enlarged cross-sectional area of the left vagus nerve in patients with major depressive disorder[J]. Front Psychiatry, 2023, 14: 1237983. doi:10.3389/fpsyt.2023.1237983.
[15]Buckley MM, O'Brien R, Brosnan E, et al. Glucagon-like peptide-1 secreting L-cells coupled to sensory nerves translate microbial signals to the host rat nervous system[J]. Front Cell Neurosci, 2020, 14: 95. doi:10.3389/fncel.2020.00095.
[16]Ni SJ, Yao ZY, Wei X, et al. Vagus nerve stimulated by microbiota-derived hydrogen sulfide mediates the regula-tion of berberine on microglia in transient middle cerebral artery occlusion rats[J]. Phytother Res, 2022, 36: 2964-2981. doi:10.1002/ptr.7490.
[17]Xie C, Gao X, Liu G, et al. USP10 is a potential mediator for vagus nerve stimulation to alleviate neuroinflammation in ischaemic stroke by inhibiting NF-κB signalling pathway[J]. Front Immunol, 2023, 14: 1130697. doi:10.3389/fimmu.2023.1130697.
[18]Min X, Wang G, Cui Y, et al. Association between inflammatory cytokines and symptoms of major depressive disorder in adults[J]. Front Immunol, 2023, 14: 1110775. doi:10.3389/fimmu.2023.1110775.
[19]Wu M, Zhao L, Wang Y, et al. Ketamine regulates the autophagy flux and polarization of microglia through the HMGB1-RAGE axis and exerts antidepressant effects in mice[J]. J Neuropathol Exp Neurol, 2022, 81: 931-942. doi:10.1093/jnen/nlac035.
[20]Xu K, Wang M, Wang H, et al. HMGB1/STAT3/p65 axis drives microglial activation and autophagy exert a crucial role in chronic stress-induced major depressive disorder[J]. J Adv Res, 2023. doi:10.1016/j.jare.2023.06.003.
[21]Moraes TR, Veras FP, Barchuk AR, et al. Spinal HMGB1 participates in the early stages of paclitaxel-induced neuropathic pain via microglial TLR4 and RAGE activation[J]. Front Immunol, 2024, 15: 1303937. doi:10.3389/fimmu.2024.1303937.
[22]Tan SW, Zhao Y, Li P, et al. HMGB1 mediates cognitive impairment caused by the NLRP3 inflammasome in the late stage of traumatic brain injury[J]. J Neuroinflammation, 2021, 18: 241. doi:10.1186/s12974-021-02274-0.
[23]Tural U, Irvin MK, Iosifescu DV. Correlation between S100B and severity of depression in MDD: a Meta-analysis[J]. World J Biol Psychiatry, 2022, 23: 456-463. doi:10.1080/15622975.2021.2013042.
[24]Ghosh D, Singh A, Kumar A, et al. High mobility group box 1 (HMGB1) inhibition attenuates lipopolysaccharide-induced cognitive dysfunction and sickness-like behavior in mice[J]. Immunol Res, 2022, 70: 633-643. doi:10.1007/s12026-022-09295-8.
[25]Xu X, Lu YN, Cheng JH, et al. Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NF-κB signaling pathway[J]. J Ginseng Res, 2022, 46: 62-70. doi:10.1016/j.jgr.2021.04.003.

诱导抑郁症患者小胶质细胞炎性反应的机制

Mechanism of inducing microglial inflammatory response in patients with depression

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 10

编辑推荐

Metrics

本文评价

[1]	高超, 张润菡, 王伟, 赵曼婷, 焦艳, 李喆. 青蒿琥酯调节cGAS-STING信号通路对抑郁症模型小鼠神经炎性反应的影响[J]. 基础医学与临床, 2024, 44(8): 1126-1132.
[2]	隋家平, 韦晖. 文拉法辛提升抑郁模型小鼠的神经元轴突结构稳定性[J]. 基础医学与临床, 2024, 44(6): 809-815.
[3]	杨琳, 曲智, 王源, 易文学, 辛锦, 尹小暖, 段东晓. m⁶A甲基转移酶样蛋白14在抑郁样小鼠海马中的表达[J]. 基础医学与临床, 2024, 44(10): 1376-1382.
[4]	李晶, 黄炳轩, 许琪. 海马内注射鸢尾素缓解小鼠抑郁样行为[J]. 基础医学与临床, 2022, 42(12): 1850-1854.
[5]	邵枝定, 高雪, 任婧, 唐晓磊. 5-羟色胺受体适配子的筛选及其抗抑郁功能[J]. 基础医学与临床, 2022, 42(10): 1514-1521.
[6]	刘丹, 蔺晓源, 杨蕙, 刘彤彤, 刘平安, 孟盼. GSK650394对慢性应激抑郁症模型大鼠行为及海马神经营养的调节作用[J]. 基础医学与临床, 2022, 42(1): 89-93.
[7]	李建国, 王颖, 李玥天, 燕子, 赵欣, 张宇. MK-801对皮质酮诱导抑郁样行为大鼠海马mBDNF和proBDNF表达的影响[J]. 基础医学与临床, 2021, 41(8): 1097-1102.
[8]	李辰, 修建波, 许琪. PARP14在3种抑郁症模型小鼠海马区的表达升高及其与神经炎性反应的关系[J]. 基础医学与临床, 2021, 41(5): 641-647.
[9]	邢靖松, 克甜甜, 张琳, 梁东, 张桐, 高尚锋. Spinophilin在神经系统疾病中的研究进展[J]. 基础医学与临床, 2021, 41(10): 1507-1509.
[10]	冯磊光邵春青刘英慧陶永红郝潇蕾. 重型抑郁症患者亚甲基四氢叶酸还原酶基因多态性检测[J]. 基础医学与临床, 2010, 30(8): 811-814.