转酮醇酶在糖尿病及其并发症发生和治疗中作用的研究进展

doi:10.16352/j.issn.1001-6325.2024.07.1023

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (7): 1023-1028.doi: 10.16352/j.issn.1001-6325.2024.07.1023

转酮醇酶在糖尿病及其并发症发生和治疗中作用的研究进展

王泽颖, 刘治, 邰玉, 杨忠彬, 苏燕^*

包头医学院生物化学与分子生物学教研室,内蒙古包头 014010

收稿日期:2023-09-15 修回日期:2024-03-19 出版日期:2024-07-05 发布日期:2024-06-26
通讯作者: ^*synmg@126.com
基金资助:
国家自然科学基金(81860029);内蒙古自然科学基金(2020MS08008);草原英才滚动计划(2021);2021年卫生健康科技计划(202201394)

Progress on the role of transketolase in occurrence and treatment of diabetes and its complications

WANG Zeying, LIU Zhi, TAI Yu, YANG Zhongbin, SU Yan^*

Department of Biochemistry and Molecular Biology, Baotou Medical College, Baotou 014010, China

Received:2023-09-15 Revised:2024-03-19 Online:2024-07-05 Published:2024-06-26
Contact: ^*synmg@126.com

摘要/Abstract

摘要： 转酮醇酶(TKT)是催化磷酸戊糖途径(PPP)非氧化阶段基团转移反应的重要酶,参与机体各类能源物质,如葡萄糖、核糖、核苷酸以及脂质的代谢。TKT可以通过抑制高糖环境下蛋白质和脂质非酶糖基化(NEG)产生的晚期糖基化终末产物(AGEs),减少氧化应激、炎性反应、动脉粥样硬化、内皮功能障碍以及Tau蛋白磷酸化等,进而改善血糖、糖耐量和β细胞功能,达到预防和治疗糖尿病及其并发症的作用。

关键词: 转酮醇酶, 糖尿病, 代谢, 磷酸戊糖途径

Abstract: Transketolase (TKT) is an important enzyme that catalyzes the non-oxidative phase group transfer reaction of pentose phosphate pathway (PPP), and is involved in the metabolism of various energy substances in the body, such as glucose, ribose, nucleotides and lipids. TKT can reduce oxidative stress, inflammation, atherosclerosis, endothelial dysfunction and Tau protein phosphorylation by inhibiting advanced glycated end-produces(AGEs) produced by non-enzymatic glycosylation (NEG) of proteins and lipids in a high-glucose environment improving blood glucose, glucose tolerance and β cell function so to prevent and treat diabetes and its complications. This article reviews research progress on the mechanism of TKT in the treatment of diabetes mellitus and its complications.

Key words: transketolase, diabetes, metabolism, pentose phosphate pathway

中图分类号:

王泽颖, 刘治, 邰玉, 杨忠彬, 苏燕. 转酮醇酶在糖尿病及其并发症发生和治疗中作用的研究进展[J]. 基础医学与临床, 2024, 44(7): 1023-1028.

WANG Zeying, LIU Zhi, TAI Yu, YANG Zhongbin, SU Yan. Progress on the role of transketolase in occurrence and treatment of diabetes and its complications[J]. Basic & Clinical Medicine, 2024, 44(7): 1023-1028.

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转酮醇酶在糖尿病及其并发症发生和治疗中作用的研究进展

Progress on the role of transketolase in occurrence and treatment of diabetes and its complications

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