衰弱患者氨基酸代谢特征的研究进展

doi:10.16352/j.issn.1001-6325.2025.02.0253

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (2): 253-257.doi: 10.16352/j.issn.1001-6325.2025.02.0253

衰弱患者氨基酸代谢特征的研究进展

吴慧珊¹, 廖颖萍², 李萌^3*

1.浙江中医药大学第二临床医学院,浙江杭州 310053;
2.广东省清远市妇幼保健院优生与遗传实验诊断中心,广东清远 511500;
3.浙江医院医学检验科,浙江杭州 310013

收稿日期:2024-09-02 修回日期:2024-12-03 出版日期:2025-02-05 发布日期:2025-01-17
通讯作者: ^*lmbcwan@163.com
基金资助:
浙江省公益技术应用项目(LGC22H200011)

Research progress in the characterization of amino acid metabolism in frailty patients

WU Huishan¹, LIAO Yingping², LI Meng^3*

1. The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053;
2. Eugenics and Genetic Experiment Diagnosis Center, Guangdong Province Qingyuan Maternal and Child Health Hospital, Qingyuan 511500;
3. Department of Clinical Laboratory, Zhejiang Hospital, Hangzhou 310013, China

Received:2024-09-02 Revised:2024-12-03 Online:2025-02-05 Published:2025-01-17
Contact: ^*lmbcwan@163.com

摘要/Abstract

摘要： 衰弱是一种力量减弱及生理机能失常的多因素相关的老年综合征。及时识别衰弱对于改善老年人生活质量具有重要意义,然而目前衰弱的诊断仍缺乏特异性的生物学标志物。近年来,适量的蛋白质摄入是老年人衰弱管理的一种有效的干预措施,衰弱与氨基酸代谢的相关性引起广泛关注。本文综述衰弱患者氨基酸代谢机制的最新研究进展,为发现衰弱的生物标志物提供新思路。

关键词: 衰弱, 氨基酸代谢, 诊断

Abstract: Frailty is a complex aging syndrome characterized by diminished strength and physiological dysfunction. Early diagnosis of frailty is of great value in helping the elderly to improve the quality of life. However, specific biological markers to diagnose frailty are still lacking. In recent years, moderate protein intake has been shown to be an effective intervention in the management of frailty in older adults, and the relationship between frailty and amino acid metabolism has received widespread attention. This review discusses recent advances in the study of the mechanisms by which amino acid metabolism affects frailty and provide new ideas for searching specific biomarkers of frailty.

Key words: frailty, amino acid metabolism, diagnose

中图分类号:

R592

吴慧珊, 廖颖萍, 李萌. 衰弱患者氨基酸代谢特征的研究进展[J]. 基础医学与临床, 2025, 45(2): 253-257.

WU Huishan, LIAO Yingping, LI Meng. Research progress in the characterization of amino acid metabolism in frailty patients[J]. Basic & Clinical Medicine, 2025, 45(2): 253-257.

参考文献 25

[1]	Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype[J]. J Gerontol A Biol Sci Med Sci, 2001, 56: 146-156.
[2]	Westbrook R,Zhang C,Yang H,et al. Metabolomics-based identification of metabolic dysfunction in frailty[J]. J Gerontol A Biol Sci Med Sci,2022,77:2367-2372.
[3]	Calvani R, Picca A, Marini F,et al. Identification of biomarkers for physical frailty and sarcopenia through a new multi-marker approach: results from the biosphere study[J]. Geroscience,2021, 43:727-740.
[4]	Zhou M, Wei Y, Feng Y,et al. Arginine regulates skeletal muscle fiber type formation via mTOR signaling pathway[J]. Int J Mol Sci, 2024,25:6184. doi: 10.3390/ijms25116184.
[5]	Mone P,Pansini A,Jankauskas SS,et al. L-arginine improves cognitive impairment in hypertensive frail older adults[J]. Front Cardiovasc Med,2022,9:868521. doi: 10.3389/fcvm.2022.868521.
[6]	Calvani R,Rodriguez-mañas L,Picca A,et al. Identifi-cation of a circulating amino acid signature in frail older persons with type 2 diabetes mellitus:results from the metabofrail study[J]. Nutrients,2020,12. doi: 10.3390/nu12010199.
[7]	Matsue Y,Kamiya K,Saito H,et al. Prevalence and prognostic impact of the coexistence of multiple frailty domains in elderly patients with heart failure:the FRAGILE-HF cohort study[J]. Eur J Heart Fail,2020,22:2112-2119.
[8]	Le Couteur DG,Ribeiro R,Senior A,et al. Branched chain amino acids,cardiometabolic risk factors and outcomes in older men:the concord health and ageing in men project[J]. J Gerontol A Biol Sci Med Sci,2020,75:1805-1810.
[9]	Adachi Y,Ono N,Imaizumi A,et al. Plasma amino acid profile in severely frail elderly patients in Japan[J]. Int J Gerontol,2018,12:290-230.
[10]	Kochlik B,Franz K,Henning T,et al. Frailty is characterized by biomarker patterns reflecting inflammation or muscle catabolism in multi-morbid patients[J]. J Cachexia Sarcopenia Muscle,2023,14:157-166.
[11]	Hamrick MW, Isales CM. Special issue: the kynurenine pathway in aging[J]. Exp Gerontol,2020,134:110895. doi: 10.1016/j.exger.2020.110895.
[12]	Marron M,Harris T,Boudreau R,et al. Metabolites associated with vigor to frailty among community-dwelling older black men[J]. Metabolites,2019,9. doi: 10.3390/metabo9050083.
[13]	Corona G,Polesel J,Fratino L,et al. Metabolomics biomarkers of frailty in elderly breast cancer patients[J]. J Cell Physiol,2014,229:898-902.
[14]	Kameda M,Teruya T,Yanagida M,et al. Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility[J]. Proc Nati Acad Sci USA,2020,117:9483-9489.
[15]	Pan Y,Li Y,Liu P,et al. Metabolomics-based frailty biomarkers in older Chinese adults[J]. Front Med (Lausanne),2021,8:830723. doi: 10.3389/fmed.2021.830723.
[16]	Zhou M, Sun W, Chu J, et al. Identification of novel biomarkers for frailty diagnosis via serum amino acids metabolomic analysis using UPLC-MS/MS[J]. Proteomics Clin Appl, 2024, 18: e2300035. doi: 10.1002/prca.202300035.
[17]	Wyse ATS, Dos Santos TM, Seminotti B, et al. Insights from animal models on the pathophysiology of hyperphenylalaninemia: role of mitochondrial dysfunction, oxidative stress and inflammation[J]. Mol Neurobiol, 2021,58:2897-2909.
[18]	Zhou Q,Sun WW,Chen JC,et al. Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ[J]. Nat Commun,2022,13:4291. doi: 10.1038/s41467-022-32000-0.
[19]	Czibik G,Mezdari Z,Murat Altinas D,et al. Dysregulated phenylalanine catabolism plays a key role in the trajectory of cardiac aging[J]. Circulation,2021,144:559-574.
[20]	Kondoh H,Kameda M,Yanagida M. Whole blood metabolomics in aging research[J]. Int J Mol Sci,2020,22:175. doi: 10.3390/ijms22010175.
[21]	Boirie Y, Pinel A, Guillet C. Protein and amino acids in obesity: friends or foes?[J]. Curr Opin Clin Nutr Metab Care,2023,26:508-513.
[22]	Moaddel R,Fabbri E,Khadeer MA,et al. Plasma biomarkers of poor muscle quality in older men and women from the baltimore longitudinal study of aging[J]. J Gerontol A Biol Sci Med Sci,2016,71:1266-1272.
[23]	Fazelzadeh P,Hangelbroek RW,Tieland M,et al. The muscle metabolome differs between healthy and frail older adults[J]. J Proteome Res,2016,15:499-509.
[24]	Voulgaridou G,Papadopoulou SD,Spanoudaki M,et al. Increasing muscle mass in elders through diet and exercise: a literature review of recent RCTs[J]. Foods, 2023,12:1218. doi: 10.3390/foods12061218.
[25]	Pujos-guillot E,Pétéra M,Jacquemin J,et al. Identifica-tion of pre-frailty sub-phenotypes in elderly using metabolomics[J]. Front Physiol,2018,9:1903. doi: 10.3389/fphys.2018.01903.

编辑推荐 0

Metrics

阅读次数

全文

HTML			PDF

最新录用	在线预览	正式出版	最新录用	在线预览	正式出版
0	0	0	0	0	14

	来源	本网站

	次数	14
	比例	100%

摘要

最新录用	在线预览	正式出版

0	0	46

	来源	本网站

	次数	46
	比例	100%

衰弱患者氨基酸代谢特征的研究进展

Research progress in the characterization of amino acid metabolism in frailty patients

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献 25

相关文章 15

编辑推荐 0

Metrics

本文评价

[1]	贾会文, 刘赟, 徐赟, 杨启, 杨科. 原发性肝癌血清miR-409-3p和miR-325-3p与介入治疗疗效相关[J]. 基础医学与临床, 2025, 45(3): 341-345.
[2]	聂牧文, 孙昭, 李宁宁, 赵林, 白春梅. 原发性心包间皮瘤的临床特征与预后[J]. 基础医学与临床, 2025, 45(2): 222-228.
[3]	李星辰, 童瑾. 鉴别肺孢子菌感染与定植的研究进展[J]. 基础医学与临床, 2025, 45(1): 116-120.
[4]	张丽娜, 贾梦涛, 孙泽云, 张建军. miR-483-3p在妊娠期糖尿病患者血清中的表达及临床意义[J]. 基础医学与临床, 2025, 45(1): 91-97.
[5]	付志刚, 覃佳, 谭江山. 门脉高压性肺动脉高压:诊治进展与挑战[J]. 基础医学与临床, 2024, 44(8): 1068-1073.
[6]	胡潮兴, 梁秋冬, 吴大鹏. 血清SAA4和SOCS1对脊柱结核与化脓性脊柱炎的早期鉴别价值[J]. 基础医学与临床, 2024, 44(7): 997-1001.
[7]	张睿, 谭妍, 马东来, 王蓉蓉, 张学. KIT杂合大片段缺失导致斑驳病一家系的临床表型[J]. 基础医学与临床, 2024, 44(7): 954-958.
[8]	王宇, 童安莉, 周玥, 张文倩, 崔云英, 景红丽, 李玉秀. ^99mTc-HYNIC-TOC显像和¹³¹I-MIBG显像在嗜铬细胞瘤和副神经节瘤中的诊断价值[J]. 基础医学与临床, 2024, 44(3): 374-378.
[9]	赵永忠, 薛懿, 李立群, 侯孟森, 杨晓军. 胆囊癌的早期影像学及循环标志物特征[J]. 基础医学与临床, 2024, 44(2): 265-269.
[10]	陆云霞, 冯悦, 姜金霞, 杨帅. 早期活动联合电刺激神经肌肉改善重症肺炎患者ICU获得性衰弱[J]. 基础医学与临床, 2024, 44(2): 242-246.
[11]	全英兰, 李宁. 甲状腺微小乳头状癌的诊断及热消融治疗[J]. 基础医学与临床, 2024, 44(12): 1722-1726.
[12]	依马木买买提江·阿布拉, 帕哈尔丁·白克热, 易超, 佟庆. 血浆hsa_circ_005230在原发性肝细胞癌诊断和预后评估中的临床价值[J]. 基础医学与临床, 2023, 43(9): 1417-1422.
[13]	颜晨红, 金儿. 外泌体PD-L1在非小细胞肺癌诊断和治疗上的研究进展[J]. 基础医学与临床, 2023, 43(9): 1457-1461.
[14]	尤丽丽, 杨丽潇, 王思瑶, 钱娜, 卢敏, 宋萌, 关玉霞. 炎性肠病患者衰弱风险预测模型的构建及评价[J]. 基础医学与临床, 2023, 43(7): 1127-1133.
[15]	楚晓云, 蔡成. 铁死亡在新生儿急性肺损伤中作用机制的研究进展[J]. 基础医学与临床, 2023, 43(6): 1008-1011.