大蒜的活性成分与骨关节炎的防治

doi:10.16352/j.issn.1001-6325.2025.02.0249

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (2): 249-252.doi: 10.16352/j.issn.1001-6325.2025.02.0249

大蒜的活性成分与骨关节炎的防治

吴思雨, 孙许涛, 曹硕, 毛彩云, 周淇, 宋运佳^*

黑龙江中医药大学基础医学院,黑龙江哈尔滨 150000

收稿日期:2024-05-16 修回日期:2024-07-15 出版日期:2025-02-05 发布日期:2025-01-17
通讯作者: ^*songyunjia666@126.com
基金资助:
黑龙江省自然科学基金(YQ2022H020);黑龙江省博士后资助项目(LBH-Z21080)

Garlic active ingredients in prevention and treatment of osteoarthritis

WU Siyu, SUN Xutao, CAO Shuo, MAO Caiyun, ZHOU Qi, SONG Yunjia^*

School of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, China

Received:2024-05-16 Revised:2024-07-15 Online:2025-02-05 Published:2025-01-17
Contact: ^*songyunjia666@126.com

摘要/Abstract

摘要： 骨关节炎(OA)是世界上普遍关注的问题。大蒜是一种天然的植物草药,其活性成分具有抗炎、抗氧化、抗分解代谢、镇痛等多种药理作用。具体表现为大蒜的活性成分通过抑制炎性因子表达,NF-κB、PI3K/Akt等信号通路减轻OA炎性反应;通过抑制ECM降解酶表达减缓OA进展;通过上调抗氧化酶表达减轻关节氧化损伤,大蒜的活性成分还可以通过激活钾离子通路(Kv7)、ATP敏感性钾通道(K-ATP)和核因子E2相关因子2(Nrf2)/血红素加氧酶1(HO-1)-醌氧化还原酶1(NQO1)信号通路缓解OA疼痛。

关键词: 大蒜, 活性成分, 防治, 骨关节炎

Abstract: Osteoarthritis(OA) is a common concern over the world. Garlic is a kind of natural herbal medicine, and its active ingredients have shown some anti-inflammatory, antioxidant, anti-catabolic, analgesic and other pharmacological effects. Garlic and its active components alleviate the inflammatory response of OA by inhibiting the expression of inflammatory factors and signal pathways such as NF-κB and PI3K/Akt. They slow down the progression of OA by inhibiting the expression of extracellular matrix (ECM) degrading enzymes. Additionally, they reduce the oxidative damage of joints by upregulating the expression of antioxidant enzymes. Moreover, the active components of garlic can relieve OA pain by activating the potassium ion pathway (Kv7), ATP-sensitive potassium channel(K-ATP), and the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1)-NAD(P)H:quinone oxidoreductase 1 (NQO1) signaling pathway.

Key words: garlic, active ingredient, prevention and treatment, osteoarthritis

中图分类号:

R969

吴思雨, 孙许涛, 曹硕, 毛彩云, 周淇, 宋运佳. 大蒜的活性成分与骨关节炎的防治[J]. 基础医学与临床, 2025, 45(2): 249-252.

WU Siyu, SUN Xutao, CAO Shuo, MAO Caiyun, ZHOU Qi, SONG Yunjia. Garlic active ingredients in prevention and treatment of osteoarthritis[J]. Basic & Clinical Medicine, 2025, 45(2): 249-252.

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大蒜的活性成分与骨关节炎的防治

Garlic active ingredients in prevention and treatment of osteoarthritis

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