G蛋白偶联受体120在呼吸系统疾病中的作用

doi:10.16352/j.issn.1001-6325.2025.02.0244

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (2): 244-248.doi: 10.16352/j.issn.1001-6325.2025.02.0244

G蛋白偶联受体120在呼吸系统疾病中的作用

赵妍妍, 张丽君, 张小春, 梁向艳, 赵玉峰^*

西安医学院基础医学研究所,陕西西安 710021

收稿日期:2024-03-11 修回日期:2024-07-15 出版日期:2025-02-05 发布日期:2025-01-17
通讯作者: ^*yufeng.zhao@xiyi.edu.cn
基金资助:
陕西省教育厅专项科研计划项目(22JK0553)

Role of G protein-coupled receptor 120 in respiratory diseases

ZHAO Yanyan, ZHANG Lijun, ZHANG Xiaochun, LIANG Xiangyan, ZHAO Yufeng^*

Institute of Basic Medical Sciences, Xi'an Medical University, Xi'an 710021, China

Received:2024-03-11 Revised:2024-07-15 Online:2025-02-05 Published:2025-01-17
Contact: ^*yufeng.zhao@xiyi.edu.cn

摘要/Abstract

摘要： G蛋白偶联受体120 (GPR120) 是长链游离脂肪酸的细胞膜受体,表达于呼吸系统的肺泡巨噬细胞和气道上皮Club细胞。GPR120激活可减轻呼吸道炎性反应,改善气道高反应性,促进Club细胞增殖,加速呼吸道上皮修复,从而减轻支气管哮喘和急性肺损伤。

关键词: GPR120, 呼吸系统, 气道上皮

Abstract: G protein-coupled receptor 120 (GPR120) is one of the membrane receptors for long chain free fatty acids and is distributed in alveolus macrophages and airway epithelial Club cells. GPR120 activation alleviates the inflammation of respiratory tract, improves airway hyper-responsiveness, stimulates proliferation of Club cells and promotes the repair of respiratory epithelium, which may attenuate asthma and acute lung injury.

Key words: GPR120, respiratory system, airway epithelium

中图分类号:

R322.3

赵妍妍, 张丽君, 张小春, 梁向艳, 赵玉峰. G蛋白偶联受体120在呼吸系统疾病中的作用[J]. 基础医学与临床, 2025, 45(2): 244-248.

ZHAO Yanyan, ZHANG Lijun, ZHANG Xiaochun, LIANG Xiangyan, ZHAO Yufeng. Role of G protein-coupled receptor 120 in respiratory diseases[J]. Basic & Clinical Medicine, 2025, 45(2): 244-248.

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G蛋白偶联受体120在呼吸系统疾病中的作用

Role of G protein-coupled receptor 120 in respiratory diseases

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