高尿酸血症在糖尿病肾病中的作用

doi:10.16352/j.issn.1001-6325.2025.03.0378

摘要/Abstract

摘要： 高尿酸血症(HUA)导致尿酸(UA)代谢异常,尿酸盐在肾脏内蓄积,不仅影响肾小球滤过功能和肾小管重吸收功能,而且还引起氧化应激、炎性反应和上调肾素-血管紧张素-醛固酮系统(RASS)等机制损害肾脏细胞及组织,促进肾纤维化同时加速糖尿病肾病(DN,DKD)的发展。这些作用机制揭示了,HUA是DKD进展的危险因素,有效控制UA为延缓DKD发展有着重要作用。

关键词: 高尿酸血症, 尿酸代谢, 糖尿病肾病

Abstract: Hyperuricemia (HUA), characterized by abnormal uric acid (UA) metabolism, leads to the accumulation of urate salts within the kidney. This accumulation not only disrupts glomerular filtration and tubular reabsorption functions but also triggers oxidative stress, inflammation,and up-regulating the renin-angiotensin-aldosterone system (RASS), all of which damage renal cells and tissues. These mechanisms contribute to renal fibrosis and accelerate the progression of diabetic nephropathy (DN)/diabetic kidney disease(DKD). These findings underscore the role of HUA as a risk factor for the advancement of DKD, emphasizing the critical importance of effective UA control in delaying its development.

Key words: hyperuricemia, uric acid metabolism, diabetic kidney disease

中图分类号:

R589

邓婕, 魏佳莉. 高尿酸血症在糖尿病肾病中的作用[J]. 基础医学与临床, 2025, 45(3): 378-381.

DENG Jie, WEI Jiali. Role of hyperuricemia in diabetic nephropathy[J]. Basic & Clinical Medicine, 2025, 45(3): 378-381.

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