P2X受体在神经病理性疼痛和偏头痛中的研究进展

doi:10.16352/j.issn.1001-6325.2025.03.0409

摘要/Abstract

摘要： 偏头痛是一种病因不明的复杂神经系统疾病,涉及遗传和环境因素,偏头痛的发病机制与小胶质细胞的激活及炎性因子密切相关。ATP是P2X受体(P2XR)的配体, P2XR是一种在神经元和神经胶质细胞中广泛表达的配体门控离子通道(LGIC)。本篇综述阐述了P2X(P2X3、P2X4、P2X7)受体通过不同机制调节小胶质细胞的激活和释放炎性因子介导神经病理性疼痛和偏头痛的发生,这将成为偏头痛治疗的潜在靶点。

关键词: 偏头痛, P2X受体, 三磷酸腺苷(ATP), 神经病理性疼痛

Abstract: Migraine is a complex neurological disorder with unknown etiology, involving genetic and environmental factors. The pathogenesis of migraine is closely related to the activation of microglia and inflammatory factors. ATP is a ligand for the P2X receptor (P2XR), a ligand gated ion channel (LGIC) widely expressed in neurons and glial cells. This review elucidates that P2X (P2X3, P2X4, P2X7) receptors regulate the activation of microglia and release of inflammatory factors through different signaling pathways, mediating neuropathic pain and migraine occurrence, providing potential targets for the treatment of migraine.

Key words: migraine, P2X receptor, adenosine triphosphate(ATP), neuropathic pain

中图分类号:

杨斌, 葛朝明. P2X受体在神经病理性疼痛和偏头痛中的研究进展[J]. 基础医学与临床, 2025, 45(3): 409-412.

YANG Bin, GE Zhaoming. Progress of P2X receptor in neuropathic pain and migraine[J]. Basic & Clinical Medicine, 2025, 45(3): 409-412.

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