摘要：
目的 探讨脑深部电刺激术（DBS）联合药物治疗原发性帕金森病的有效性和安全性。方法 共60 例原发性帕金森病患者分别予常规药物治疗（30 例）和脑深部电刺激术联合药物治疗（30 例），采用统一帕金森病评价量表（UPDRS）和帕金森病生活质量量表（PDQUALIF）评价病情严重程度和生活质量。结果 DBS 组患者UPDRS 量表之精神、行为和情绪（P = 0.023）、日常生活活动能力（P = 0.005）、运动功能（P = 0.025）和运动并发症（P = 0.008）以及PDQUALIF 评分（P = 0.016）均低于对照组，治疗后UPDRS量表之精神、行为和情绪（P = 0.003）、日常生活活动能力（P = 0.016）、运动功能（P = 0.001）和运动并发症（P = 0.016）以及PDQUALIF 评分（P = 0.000）亦低于治疗前。DBS 组总有效率［96.67%（29/30）］高于对照组［76.67%（23/30）；χ2 = 5.109，P = 0.000］结论 脑深部电刺激术联合药物治疗原发性帕金森病可以有效改善临床症状，提高生活质量。
关键词:
帕金森病,
深部脑刺激法,
药物疗法
Abstract:
Objective To study the efficacy and safety of deep brain stimulation (DBS) combined with drug therapy in the treatment of idiopathic Parkinson's disease (PD). Methods From August 2013 to August 2015, 60 patients with idiopathic PD were enrolled. They were divided into DBS group (N = 30) and control group (N = 30) based on different treatment methods. The control group was given routine drug therapy, while DBS group was given DBS combined with drug therapy. Unified Parkinson's Disease Rating Scale (UPDRS) and Parkinson's Disease Quality of Life Scale (PDQUALIF) were used to evaluate the severity of disease and quality of life. Results In comparison with control group, UPDRS suggested lower mind, behavior and mood score (P = 0.023), lower activities of daily living score (P = 0.005), lower motor function score (P = 0.025), lower motor complications score (P = 0.008) and lower PDQUALIF score (P = 0.016) in DBS group. In comparison with scores in DBS group before treatment, UPDRS suggested lower mind, behavior and mood score (P = 0.003), lower activities of daily living score (P = 0.016), lower motor function score (P = 0.001), lower motor complications score (P = 0.016) and lower PDQUALIF score (P = 0.000) after treatment. Total effective rate was found higher in DBS group [96.67% (29/30); χ 2 = 5.109, P = 0.000] than that in control group [76.67% (23/30)]. Conclusions DBS combined with drug therapy can effectively improve clinical symptoms and quality of life in patients with idiopathic PD.
Key words:
Parkinson disease,
Deep brain stimulation,
Drug therapy
孟莉, 郑德利, 刘娜, 李艳敏, 王铭维. 脑深部电刺激术联合药物治疗原发性帕金森病疗效观察[J]. 中国现代神经疾病杂志, 2017, 17(2): 121-126.
MENG Li, ZHENG De-li, LIU Na, LI Yan-min, WANG Ming-wei. Clinical observation on the effect of deep brain stimulation combined with drug therapy in the treatment of idiopathic Parkinson's disease[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2017, 17(2): 121-126.