摘要： 帕金森病是临床常见的神经系统变性疾病,可累及呼吸系统,其相关呼吸系统并发症是主要死因,但发病机制及其与帕金森病运动症状和非运动症状严重程度、药物治疗及疾病表型等关系尚未完全阐明。本文综述解剖生理学基础、疾病自身和治疗相关呼吸功能障碍等研究进展,以加深对帕金森病相关呼吸功能障碍的认识,为疾病治疗提供新的思路。

关键词: 帕金森病, 呼吸障碍, 左旋多巴, 深部脑刺激法, 综述

Abstract: Parkinson's disease (PD), a common degenerative disease of the central nervous system, can affect the respiratory system. Pulmonary complications remain its leading cause of death, but the pathogenesis and its relationship to the severity of motor symptoms and non - motor symptoms, medication, and disease phenotype in PD have not been fully elucidated. This article reviews the advances in research on the anatomical and physiological basis, the disease itself and treatment- related respiratory disturbances to deepen the understanding of respiratory dysfunction associated with PD and to provide new insights for treatment.

Key words: Parkinson disease, Respiration disorders, Levodopa, Deep brain stimulation, Review