年龄相关性黄斑变性的研究进展

doi:10.16352/j.issn.1001-6325.2024.04.0553

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (4): 553-557.doi: 10.16352/j.issn.1001-6325.2024.04.0553

年龄相关性黄斑变性的研究进展

魏丹丹^*, 宋宇涵, 王淇, 宿树兰, 朱悦, 段金廒^*

南京中医药大学中药资源产业化与方剂创新药物国家地方联合工程研究中心/江苏省中药资源产业化过程协同创新中心/江苏省方剂高技术研究重点实验室,江苏南京 210023

收稿日期:2023-04-11 修回日期:2023-12-27 出版日期:2024-04-05 发布日期:2024-03-25
通讯作者: ^*wei.dandan@njucm.edu.cn;dja@njucm.edu.cn
基金资助:
国家自然科学基金(82173965,U21A20408);江苏省研究生实践创新项目(SJCX22_0806,SJCX23_0768);国家中医药管理局高水平中医药重点学科建设项目(国中医药人教函[2023]85号)

Research advances on the age-related macular degeneration

WEI Dandan^*, SONG Yuhan, WANG Qi, SU Shulan, ZHU Yue, DUAN Jin'ao^*

National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and FormulaeInnovative Medicine/Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization/ Jiangsu Key Laboratory forTraditional Chinese Medicine Formulae Research, Nanjing University of Chinese Medicine, Nanjing 210023, China

Received:2023-04-11 Revised:2023-12-27 Online:2024-04-05 Published:2024-03-25
Contact: ^*wei.dandan@njucm.edu.cn;dja@njucm.edu.cn

摘要/Abstract

摘要： 年龄相关性黄斑变性(AMD)严重威胁老年人视力健康,视网膜色素上皮细胞(RPE)功能障碍是其关键环节。年龄增长导致RPE复制性衰老,光暴露、香烟暴露等导致RPE压力性早衰,衰老的RPE细胞溶酶体消化能力下降导致脂褐素积累,触发早期AMD的发生。老化的视网膜内细胞衰老-更新失衡、氧化压力-抗氧化失衡、慢性炎性反应-抗炎失衡、肠道屏障和肠道微生态失衡、促血管生成-抗血管生成失衡一系列内稳态失衡进一步促进AMD的发展。

Abstract: Age-related macular degeneration(AMD) is a serious threat to the visual health of the elderly, and the dysfunction of retinal pigment epithelial cells(RPE) is a significant etiology risk. Aging process leads to RPE replication senescence, and some environment factors like light exposure and cigarette exposure may lead to RPE stress premature aging, and the decreased lysosomal digestion ability of senescent RPE cells may lead to the accumulation of lipofuscin, triggering the occurrence of early AMD. A series of homeostatic imbalances in aging retina, such as cell senescence-renewal imbalance, oxidative stress-antioxidant imbalance, chronic inflammatory-anti-inflammatory imbalance, intestinal barrier and intestinal microbiota imbalance and pro-angiogenesis-antiangiogenic imbalance all contribute to the development of AMD.

Key words: age-related macular degeneration(AMD), retina, retinal pigment epithelial cells(RPE), cellular senescence

中图分类号:

R774

魏丹丹, 宋宇涵, 王淇, 宿树兰, 朱悦, 段金廒. 年龄相关性黄斑变性的研究进展[J]. 基础医学与临床, 2024, 44(4): 553-557.

WEI Dandan, SONG Yuhan, WANG Qi, SU Shulan, ZHU Yue, DUAN Jin'ao. Research advances on the age-related macular degeneration[J]. Basic & Clinical Medicine, 2024, 44(4): 553-557.

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年龄相关性黄斑变性的研究进展

Research advances on the age-related macular degeneration

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