IgG N-糖基化修饰在糖尿病视网膜病变中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.03.509

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (3): 509-513.doi: 10.16352/j.issn.1001-6325.2023.03.509

IgG N-糖基化修饰在糖尿病视网膜病变中作用的研究进展

张艺馨¹, 蔡善君^1*, 李智立², 于伟泓³, 张华^4*

1.遵义医科大学附属医院眼科,贵州遵义 563003;
2.中国医学科学院基础医学研究所北京协和医学院基础学院生物物理及结构生物学系,北京 100005;
3.中国医学科学院北京协和医学院北京协和医院眼科;
4.继续教育学院,北京 100730

收稿日期:2022-04-02 修回日期:2022-10-17 出版日期:2023-03-05 发布日期:2023-02-27
通讯作者: * zhanghua.eye@163.com;caishanjun@163.com
基金资助:
京津冀基础研究合作专项项目(J200006)

Research progress on the role of IgG N-glycosylation modification in diabetic retinopathy

ZHANG Yixin¹, CAI Shanjun^1*, LI Zhili², YU Weihong³, ZHANG Hua^4*

1. Department of Ophthalmology, Affiliated Hospital of Zunyi Medical University, Zunyi 563003;
2. Department of Biophysics and Structural Biology, Institute of Basic Medical Sciences CAMS, School of Basic Medicine PUMC, Beijing 100005;
3. Department of Ophthalmology, Peking Union Medical College Hospital;
4. College of Continuing Education, CAMS ＆ PUMC, Beijing 100730, China

Received:2022-04-02 Revised:2022-10-17 Online:2023-03-05 Published:2023-02-27
Contact: * zhanghua.eye@163.com;caishanjun@163.com

摘要/Abstract

摘要： 糖尿病视网膜病变(DR)是免疫炎性疾病,免疫球蛋白G(IgG) N-糖基化修饰与DR密切相关。其中,IgG的半乳糖基化修饰、岩藻糖基化修饰、唾液酸化和平分型N-乙酰葡糖胺修饰发生变化,导致机体处于促炎状态,诱导视网膜发生病变。

关键词: 糖尿病视网膜病变, 免疫球蛋白G, 糖基化修饰

Abstract: Diabetic retinopathy (DR) is an immune-inflammatory disease and immunoglobulin G(IgG) N-glycosylation modifications are closely associated with DR. Among them, the modification of galactosylation, fucosylation, sialylation and bisecting N-acetylglucosamine of IgG changed has been proved to be predisposing factor to stimulate inflammation and related retinopathy.

Key words: diabetic retinopathy, immunoglobulin G, glycosylation modification

中图分类号:

R774.1

张艺馨, 蔡善君, 李智立, 于伟泓, 张华. IgG N-糖基化修饰在糖尿病视网膜病变中作用的研究进展[J]. 基础医学与临床, 2023, 43(3): 509-513.

ZHANG Yixin, CAI Shanjun, LI Zhili, YU Weihong, ZHANG Hua. Research progress on the role of IgG N-glycosylation modification in diabetic retinopathy[J]. Basic & Clinical Medicine, 2023, 43(3): 509-513.

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IgG N-糖基化修饰在糖尿病视网膜病变中作用的研究进展

Research progress on the role of IgG N-glycosylation modification in diabetic retinopathy

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