非酒精性脂肪性肝病中自噬与铁死亡相互作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.08.1294

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (8): 1294-1298.doi: 10.16352/j.issn.1001-6325.2023.08.1294

非酒精性脂肪性肝病中自噬与铁死亡相互作用的研究进展

李想, 李晔^*

昆明理工大学医学院基础医学系,云南昆明 650500

收稿日期:2022-06-15 修回日期:2022-11-13 出版日期:2023-08-05 发布日期:2023-07-26
通讯作者: ^*liye918@gmail.com
基金资助:
国家自然科学基金(81460167);云南省教育厅科学研究基金(2019J0041);云南省万人计划“青年拔尖人才”专项(YNWR-QNBJ-2018-126)

Research progress on the interaction between autophagy and ferroptosis in non-alcoholic fatty liver disease

LI Xiang, LI Ye^*

Department of Basic Medicine, Medical School, Kunming University of Science and Technology, Kunming 650500, China

Received:2022-06-15 Revised:2022-11-13 Online:2023-08-05 Published:2023-07-26
Contact: ^*liye918@gmail.com

摘要/Abstract

摘要： 自噬和铁死亡作为细胞中重要的生物学过程,在肝细胞中维持脂质累积稳态、氧化应激和脂质过氧化平衡方面起到重要作用。本文从肝脏脂肪代谢过程中,自噬过程直接影响脂质异常累积,到其与铁死亡氧化应激和脂质过氧化的关系,以及自噬与铁死亡的相互作用,从而对非酒精性脂肪性肝病(NAFLD)病程的影响进行综述。研究自噬与铁死亡相互作用或许能为NAFLD治疗提供一些新思路。

关键词: 非酒精性脂肪肝病, 自噬, 铁死亡, 脂代谢

Abstract: In hepatocytes, autophagy and ferroptosis, as important biological processes in cells, play important roles in maintaining lipid accumulation homeostasis, oxidative stress and lipid peroxidation balance. Here we reviewed the impact of autophagy on the abnormal lipids accumulation in the process of liver lipid metabolism, and its relationship with ferroptosis, which was marked by oxidative stress and lipid peroxidation. The impact of the interaction between autophagy and ferroptosis on the course of non-alcoholic fatty liver disease (NAFLD) might provide some new ideas for the treatment of NAFLD.

Key words: non-alcoholic fatty liver disease, autophagy, ferroptosis, lipid metabolism

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李想, 李晔. 非酒精性脂肪性肝病中自噬与铁死亡相互作用的研究进展[J]. 基础医学与临床, 2023, 43(8): 1294-1298.

LI Xiang, LI Ye. Research progress on the interaction between autophagy and ferroptosis in non-alcoholic fatty liver disease[J]. Basic & Clinical Medicine, 2023, 43(8): 1294-1298.

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非酒精性脂肪性肝病中自噬与铁死亡相互作用的研究进展

Research progress on the interaction between autophagy and ferroptosis in non-alcoholic fatty liver disease

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