铁死亡在结直肠癌治疗中的作用

doi:10.16352/j.issn.1001-6325.2023.01.0174

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (1): 174-177.doi: 10.16352/j.issn.1001-6325.2023.01.0174

铁死亡在结直肠癌治疗中的作用

庄志诚, 官国先^*

福建医科大学附属第一医院结直肠外科, 福建福州 350005

收稿日期:2021-09-07 修回日期:2021-12-31 发布日期:2022-12-27
通讯作者: ^*fjxhggx@163.com
基金资助:
国家自然科学基金(82172800)

Ferroptosis in the treatment of colorectal cancer

ZHUANG Zhicheng, GUAN Guoxian^*

Department of Colorectal Surgery,the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China

Received:2021-09-07 Revised:2021-12-31 Published:2022-12-27
Contact: ^*fjxhggx@163.com

摘要/Abstract

摘要： 铁死亡是近年来发现的一种由铁依赖的脂质活性氧蓄积所引发的程序性细胞死亡形式。其发生取决于细胞内铁稳态、脂代谢以及抗氧化系统三者的综合变化。结直肠癌是常见的消化道恶性肿瘤之一。通过诱导铁死亡途径能有效的抑制结直肠癌细胞的增殖、逆转耐药性以及提高结直肠癌细胞的放射敏感性等。

关键词: 结直肠癌, 铁死亡, 肿瘤治疗, 放射治疗, 化学治疗

Abstract: Ferroptosis is a form of programmed cell death caused by accumulation of iron-dependent lipophilic reactive oxygen species. Its occurrence depends on the comprehensive changes of intracellular iron homeostasis, lipid metabolism and antioxidant system. Colorectal cancer is one of the common malignant tumors of the digestive tract. It can effectively inhibit the proliferation of colorectal cancer cells, reverse drug resistance and improve the radio sensitivity of colorectal cancer cells by inducing ferroptosis pathway.

Key words: colorectal cancer, ferroptosis, cancer treatment, radiation therapy, chemotherapy

中图分类号:

R735.3

庄志诚, 官国先. 铁死亡在结直肠癌治疗中的作用[J]. 基础医学与临床, 2023, 43(1): 174-177.

ZHUANG Zhicheng, GUAN Guoxian. Ferroptosis in the treatment of colorectal cancer[J]. Basic & Clinical Medicine, 2023, 43(1): 174-177.

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铁死亡在结直肠癌治疗中的作用

Ferroptosis in the treatment of colorectal cancer

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