铁死亡在阿尔茨海默病中作用的研究进展

doi:10.16352/j.issn.1001-6325.2022.07.1129

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (7): 1129-1133.doi: 10.16352/j.issn.1001-6325.2022.07.1129

铁死亡在阿尔茨海默病中作用的研究进展

徐娟, 李晔^*

昆明理工大学医学院, 云南昆明 650500

收稿日期:2021-10-28 修回日期:2022-05-07 出版日期:2022-07-05 发布日期:2022-06-29
通讯作者: * liye918@gmail.com
基金资助:
国家自然科学基金(81460167);云南省教育厅科学研究基金(2019J0041);云南省万人计划“青年拔尖人才”专项(YNWR-QNBJ-2018-126)

Research progress on the role of ferroptosis in Alzheimer's disease

XU Juan, LI Ye^*

School of Medicine, Kunming University of Science and Technology, Kunming 650500, China

Received:2021-10-28 Revised:2022-05-07 Online:2022-07-05 Published:2022-06-29
Contact: * liye918@gmail.com

摘要/Abstract

摘要： 阿尔茨海默病(AD)是老年人中最高发的神经退行性疾病。AD患者表现出来的进行性神经元丢失和死亡,及与脑铁异常水平相关的高氧化应激等症状,可能与铁死亡这种新型细胞死亡方式相关。铁死亡的两大特征,铁稳态失调和脂质过氧化可以将铁死亡和AD联系起来。铁死亡或许能为AD治疗提供一些新思路。

关键词: 阿尔茨海默病(AD), 铁死亡, 铁稳态失调, 脂质过氧化

Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly. The symptoms of progressive neuronal loss and death in AD, as well as the hyper-oxidative stress associated with abnormal brain iron levels, may be related to ferroptosis, a new way of cell death. Two characteristics of ferroptosis, iron homeostasis and lipid peroxidation, may potentially link ferroptosis to AD. The research on potential role of ferroptosis may provide new ideas for the treatment of AD.

Key words: Alzheimer's disease(AD), ferroptosis, iron homeostasis disorder, lipid peroxidation

中图分类号:

R741

徐娟, 李晔. 铁死亡在阿尔茨海默病中作用的研究进展[J]. 基础医学与临床, 2022, 42(7): 1129-1133.

XU Juan, LI Ye. Research progress on the role of ferroptosis in Alzheimer's disease[J]. Basic & Clinical Medicine, 2022, 42(7): 1129-1133.

0
/ / 推荐

导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

链接本文: http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/10.16352/j.issn.1001-6325.2022.07.1129

http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2022/V42/I7/1129

参考文献 25

[1]	The Alzheimer's Association. 2021 Alzheimer's disease facts and figures[J]. Alzheimers Dement, 2021, 17: 327-406.
[2]	Gerrits E, Brouwer N, Kooistra SM, et al. Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease[J]. Acta Neuropathol, 2021, 141: 681-696.
[3]	张研, 魏来. APPswe/PS1dE9双转基因小鼠中轴突异常与阿尔茨海默病的联系[J].基础医学与临床, 2019, 39: 1525-1529.
[4]	Riegman M, Sagie L, Galed C, et al. Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture[J]. Nat Cell Biol, 2020, 22: 1042-1048.
[5]	Huang L, McClatchy DB, Maher P, et al. Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death[J]. Cell Death Dis, 2020, 11: 828. doi: 10.1038/s41419-020-03020-9.
[6]	Bao WD, Pang P, Zhou XT, et al. Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease[J]. Cell Death Differ, 2021, 28: 1548-1562.
[7]	Ayton S, Wang Y, Diouf I, et al. Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology[J]. Mol Psychiatry, 2020, 25: 2932-2941.
[8]	Stockwell BR, Jiang X, Gu W. Emerging mechanisms and disease relevance of ferroptosis[J]. Trends Cell Biol, 2020, 30: 478-490.
[9]	Butterfield DA. Brain lipid peroxidation and alzheimer disease: synergy between the Butterfield and Mattson laboratories[J]. Ageing Res Rev, 2020, 64: 101049. doi:10.1016/j.arr.2020.101049.
[10]	Han J, Park H, Maharana C, et al. Alzheimer's disease-causing presenilin-1 mutations have deleterious effects on mitochondrial function[J]. Theranostics, 2021, 11: 8855-8873.
[11]	Wang C, Cai X, Wang R, et al. Neuroprotective effects of verbascoside against Alzheimer's disease via the relief of endoplasmic reticulum stress in Abeta-exposed U251 cells and APP/PS1 mice[J]. J Neuroinflammation, 2020, 17: 309. doi: 10.1186/s12974-020-01976-1.
[12]	Kapralov AA, Yang Q, Dar HH, et al. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death[J]. Nat Chem Biol, 2020, 16: 278-290.
[13]	Reis J, Massari M, Marchese S, et al. A closer look into NADPH oxidase inhibitors: validation and insight into their mechanism of action[J]. Redox Biol, 2020, 32: 101466. doi: 10.1016/j.redox.2020.101466.
[14]	Park MW, Cha HW, Kim J, et al. NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases[J]. Redox Biol, 2021, 41: 101947. doi: 10.1016/j.redox.2021.101947.
[15]	Ates G, Goldberg J, Currais A, et al. CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of Alzheimer's disease[J]. Redox Biol, 2020, 36: 101648. doi: 10.1016/j.redox.2020.101648.
[16]	Miyake S, Murai S, Kakuta S, et al. Identification of the hallmarks of necroptosis and ferroptosis by transmission electron microscopy[J]. Biochem Biophys Res Commun, 2020, 527: 839-844.
[17]	Floros KV, Cai J, Jacob S, et al. MYCN-amplified neuroblastoma is addicted to iron and vulnerable to inhibition of the system Xc-/glutathione axis[J]. Cancer Res, 2021, 81: 1896-1908.
[18]	Ashraf A, Jeandriens J, Parkes HG, et al. Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer's disease: evidence of ferroptosis[J]. Redox Biol, 2020, 32: 101494. doi: 10.1016/j.redox.2020.101494.
[19]	Zhang Y, Swanda RV, Nie L, et al. mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation[J]. Nat Commun, 2021, 12: 1589. doi: 10.1038/s41467-021-21841-w.
[20]	Zhang HL, Hu BX, Li ZL, et al. PKCβⅡ phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis[J]. Nat Cell Biol, 2022, 24: 88-98.
[21]	Gleason A, Bush AI. Iron and ferroptosis as therapeutic targets in Alzheimer's disease[J]. Neurotherapeutics, 2021, 18: 252-264.
[22]	Zuo Y, Xie J, Li X, et al. Ferritinophagy-mediated ferroptosis involved in paraquat-induced neurotoxicity of dopaminergic neurons: implication for neurotoxicity in PD[J]. Oxid Med Cell Longev, 2021, 2021: 9961628. doi: 10.1155/2021/9961628.
[23]	Doll S, Freitas FP, Shah R, et al. FSP1 is a glutathione-independent ferroptosis suppressor[J]. Nature, 2019, 575: 693-698.
[24]	Kraft VAN, Bezjian CT, Pfeiffer S, et al. GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling[J]. ACS Cent Sci, 2020, 6: 41-53.
[25]	Mao C, Liu X, Zhang Y, et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer[J]. Nature, 2021, 593: 586-590.

铁死亡在阿尔茨海默病中作用的研究进展

Research progress on the role of ferroptosis in Alzheimer's disease

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献 25

相关文章 3

编辑推荐

Metrics

本文评价

[1]	薛晋芳, 宋海飞, 陈国兵. 程序性细胞死亡在脓毒症发生发展中的研究进展[J]. 基础医学与临床, 2022, 42(8): 1284-1287.
[2]	孙健茹, 仇文颖, 钱晓菁, 马超. Fc-gamma Ⅰ型受体在阿尔茨海默病患者和模型小鼠脑皮质的表达[J]. 基础医学与临床, 2022, 42(5): 740-744.
[3]	徐飞, 陈维达, 郭溟浩, 陈泽涛. 铁死亡调控机制及在肺癌治疗中的研究进展[J]. 基础医学与临床, 2021, 41(3): 442-447.