铁死亡在新生儿急性肺损伤中作用机制的研究进展

doi:10.16352/j.issn.1001-6325.2023.06.1008

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (6): 1008-1011.doi: 10.16352/j.issn.1001-6325.2023.06.1008

铁死亡在新生儿急性肺损伤中作用机制的研究进展

楚晓云, 蔡成^*

上海市儿童医院上海交通大学医学院附属儿童医院新生儿科,上海 200062

收稿日期:2022-06-10 修回日期:2022-10-13 出版日期:2023-06-05 发布日期:2023-05-31
通讯作者: ^*caicheng2004@163.com
基金资助:
上海市儿童医院院级课题国家自然科学基金培育专项(2020YGZQ01)

Research progress on the mechanism of ferroptosis in neonatal acute lung injury

CHU Xiaoyun, CAI Cheng^*

Department of Neonatology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062, China

Received:2022-06-10 Revised:2022-10-13 Online:2023-06-05 Published:2023-05-31
Contact: ^*caicheng2004@163.com

摘要/Abstract

摘要： 急性肺损伤是新生儿中常见的一种危急重症,铁死亡作为一种新型细胞程序性死亡形式,可通过调节铁稳态、氨基酸代谢和脂质过氧化反应参与急性肺损伤的进程。深入研究铁死亡在急性肺损伤中的作用机制可为其防治提供新思路。

关键词: 铁死亡, 铁稳态, 氨基酸代谢, 脂质过氧化, 新生儿急性肺损伤

Abstract: Acute lung injury is a common critical illness in neonates. Ferroptosis, a novel form of programmed cell death, plays an important role in the process of acute lung injury by regulating iron homeostasis, metabolism of amino acid and lipid peroxidation. In-depth study of the mechanism of ferroptosis in acute lung injury may provide new ideas for its prevention and treatment.

Key words: ferroptosis, iron homeostasis, metabolism of amino acid, lipid peroxidation, acute lung injury in neonate

中图分类号:

R725.6

楚晓云, 蔡成. 铁死亡在新生儿急性肺损伤中作用机制的研究进展[J]. 基础医学与临床, 2023, 43(6): 1008-1011.

CHU Xiaoyun, CAI Cheng. Research progress on the mechanism of ferroptosis in neonatal acute lung injury[J]. Basic & Clinical Medicine, 2023, 43(6): 1008-1011.

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铁死亡在新生儿急性肺损伤中作用机制的研究进展

Research progress on the mechanism of ferroptosis in neonatal acute lung injury

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