Mechanisms and clinical advances in transcranial alternating current stimulation for the treatment of depression

doi:10.3969/j.issn.1672-6731.2026.01.013

Abstract

Abstract: Transcranial alternating current stimulation (tACS) is a non-invasive neuromodulation technique that applies low -intensity sinusoidal currents at specific frequencies to interact with endogenous neural oscillations. By modulating neuronal firing synchrony, tACS can improve neural functions. In recent years, this technique has shown potential in the treatment of depression. This article reviews advances in the application of various tACS modalities in depression, discusses optimization strategies and future directions, and provides insights for clinical practice and further research.

Key words: Depressive disorder, Electric stimulation therapy, Review

摘要： 经颅交流电刺激作为一种非侵入性神经调控技术，通过特定频率的交流电与内源性神经振荡相互作用，调节神经元放电同步性，改善神经功能。近年该项技术在抑郁症的治疗中展现出潜力。本文综述不同类型经颅交流电刺激在抑郁症中的应用进展，探讨其优化策略及发展方向，为临床实践和临床研究提供参考。

关键词: 抑郁症, 电刺激疗法, 综述

CLC Number:

R741
R651

YANG Xin, WANG Shu-zhe, LI Shen. Mechanisms and clinical advances in transcranial alternating current stimulation for the treatment of depression[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2026, 26(1): 92-98.

杨鑫, 王书哲, 李申. 经颅交流电刺激治疗抑郁症机制研究与应用进展[J]. 中国现代神经疾病杂志, 2026, 26(1): 92-98.

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URL: https://journal11.magtechjournal.com/cjcnn/EN/10.3969/j.issn.1672-6731.2026.01.013

https://journal11.magtechjournal.com/cjcnn/EN/Y2026/V26/I1/92

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