25 September 2026, Volume 26 Issue 9
    

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  • Emphasizing the application of combined cerebral and cardiac arterial assessment in atherosclerosis-related ischemic cerebrovascular disease
    MA Xin, GU Ya-qin, LI Yuan-yuan
    Chinese Journal of Contemporary Neurology and Neurosurgery. 2026, 26(9): 935-940. https://doi.org/10.3969/j.issn.1672-6731.2026.09.001
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    Atherosclerosis-related ischemic cerebrovascular disease (ICVD) is not always an isolated cerebral arterial event; rather, it is mostly the cerebral clinical manifestation of systemic multi-vascular bed disease. Atherosclerosis in the intracranial arteries, cervical arteries, thoracic aorta, and coronary arteries tends to co-exist because they share common risk factors and an inflammatory basis, affecting the diagnosis, treatment and prognosis of ICVD in various ways. Consequently, the value of a joint brain-heart arterial assessment is gaining increasing recognition. There are various modalities for evaluating the head and neck arteries, among which CT angiography (CTA) is widely applied and offers high diagnostic value. Since coronary CTA (CCTA) is also a commonly used examination method for coronary artery lesions, a combined brain-heart CTA scan provides distinct detection advantages. Furthermore, a combined brain-heart arterial evaluation should integrate electrocardiogram monitoring, echocardiography and clinical information to facilitate the determination of etiology, short-term safety evaluation, and comprehensive long-term risk assessment for ICVD.
    • Special Review
  • Advance in atherosclerotic cerebral-cardiac vascular disease
    CHI Heng, LIU Bei-bei, YI Li, LI Jin-xin, ZHAO Ying-ying, ZHANG Yong-bo
    Chinese Journal of Contemporary Neurology and Neurosurgery. 2026, 26(9): 941-945. https://doi.org/10.3969/j.issn.1672-6731.2026.09.002
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    Cerebrovascular disease and coronary heart disease pose serious threats to global human health. The coexistence of the two conditions, termed cerebral-cardiac vascular disease, is linked to increased the disability and mortality, imposing a substantial economic burden worldwide. However, there are still considerable unresolved issues in early prevention, accurate diagnosis and effective treatment of cerebral-cardiac vascular disease in clinical practice. Here we reviewed the epidemiology, comorbidity risk, pathophysiological mechanism, imaging examination, as well as the treatment of atherosclerotic cerebral-cardiac vascular disease.
  • Research on immune checkpoint inhibitors-associated myocarditis-myositis-myasthenia gravis overlap syndrome
    SHANG Zhi-yue, HAO Shuai, WANG Jian-hong, LI Wei-rong
    Chinese Journal of Contemporary Neurology and Neurosurgery. 2026, 26(9): 946-953. https://doi.org/10.3969/j.issn.1672-6731.2026.09.003
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    Immune checkpoint inhibitors (ICIs), owing to their remarkable therapeutic efficacy, have become a widely adopted therapeutic modality for various malignancies. The excessive immune response elicited during treatment can induce autoimmune injury in multiple organs, manifesting as immune-related adverse events (irAEs), including ICIs-associated myocarditis, myositis and myasthenia gravis. These conditions are clinically rare, with low incidence but high mortality, and their overlapping occurrence is associated with an even poorer prognosis. Endomyocardial biopsy, cardiac MRI, and serological biomarkers [e.g., cardiac troponin, creatine kinase (CK), and anti-acetylcholine receptor (AChR) antibody] serve as important diagnostic modalities. Currently, the clinical management and treatment of irAEs still lack high-level evidence-based medical evidence. Further exploration of the key molecular mechanisms underlying neuro-cardiac crosstalk, identification of effective therapeutic targets, and development of corresponding intervention strategies-combined with early recognition and multi-disciplinary collaboration-hold substantial clinical value for improving patient prognosis. This review systematically summarizes the epidemiological characteristics, pathophysiological mechanisms, clinical manifestations, diagnosis, and treatment advances of ICIs-associated myocarditis-myositis-myasthenia gravis overlap syndrome (3M syndrome), aiming to provide a reference for future research and thereby promote the precise diagnosis, treatment, and clinical management optimization of this disease.
  • Advance in risk assessment tools for adverse prognosis in patients with syncope
    WANG Yan-ling, MA Xin
    Chinese Journal of Contemporary Neurology and Neurosurgery. 2026, 26(9): 954-961. https://doi.org/10.3969/j.issn.1672-6731.2026.09.004
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    Syncope is defined as transient loss of consciousness induced by cerebral hypoperfusion. As a common clinical neurological syndrome with diverse etiologies, certain syncope subtypes are associated with adverse prognosis and fatal complications. Risk stratification is essential for standardized diagnosis and management of syncope. This study systematically reviews recent literature on the classification of syncope, current risk assessment tools, and existing challenges in prognostic assessment of syncope. The efficacy of various assessment tools in identifying high risk patients and predicting short-term and long-term prognoses are summarized, and their limitations in clinical decision-making are analyzed. Further high quality clinical investigations are required to develop more accurate and individualized risk prediction models. The present review provides theoretical basis and evidence-based references for optimized risk evaluation, precise stratified management, and clinical decision-making in patients with syncope.
    • Epidemiological Investigation Study
  • An investigative study on seasonal variation of blood pressure in elderly hypertensive populations from a community in Tianjin
    HAN Xue, XUE Juan-juan, LI Qiang, WANG Lin, LI Xin
    Chinese Journal of Contemporary Neurology and Neurosurgery. 2026, 26(9): 962-971. https://doi.org/10.3969/j.issn.1672-6731.2026.09.005
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    Objective To explore seasonal blood pressure variability in elderly hypertensive populations.Methods Total 2142 elderly hypertensive patients underwent physical examination in Chentangzhuang Street Community Health Service Center, Hexi District, Tianjin from January 1, 2017 to December 31, 2019 were enrolled. The differences in blood pressure and blood pressure variability among different seasons were analyzed. Univariate and multivariate Logistic regression analyses were adopted to screen influencing factors for blood pressure variability in elderly hypertensive populations. Subgroup analyses of blood pressure and blood pressure variability stratified by age and gender were further performed.Results There were statistically significant differences in systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP) and mean arterial pressure (MAP) across different seasons (P=0.000, for all). Pairwise comparison indicated that SBP in winter and spring was higher than that in summer (P=0.001, 0.000) and autumn (P=0.003, 0.002); DBP in winter and spring was higher than that in summer (P=0.001, 0.029), and DBP in autumn was higher than that in summer (P=0.035). PP in winter and spring was higher than that in autumn (P=0.005, 0.000), and PP in spring was higher than that in summer (P=0.004). MAP in winter and spring was higher than that in summer (P=0.000, 0.001), and MAP in winter was higher than that in autumn (P=0.045). There was a significant difference in systolic blood pressure coefficient variation (SBPCV) among different seasons (P=0.043). Pairwise comparison showed that SBPCV in winter was higher than that in summer (P=0.046). Logistic regression analysis showed that smoking cessation was protective factor for stable SBP variability (OR=0.549, 95%CI: 0.344-0.877;P=0.012). Autumn (OR=1.422, 95%CI: 1.028-1.966;P=0.033) and winter (OR=1.280, 95%CI: 1.006-1.628;P=0.044) were risk factors for increased SBP variability; winter was risk factor for increased DBP variability (OR=1.406, 95%CI: 1.108-1.785;P=0.005). Age subgroup analysis showed that SBP and PP differed significantly among the 60-69 years group, 70-79 years group and ≥80 years group (P=0.000, for all). SBP and PP in the ≥80 years group were higher than those in the 60-69 years group (P=0.000, 0.000) and 70-79 years group (P=0.005, 0.000), while the 70-79 years group had higher SBP and PP than the 60-69 years group (P=0.000, 0.000). There was a significant difference in diastolic blood pressure coefficient variation (DBPCV) among the 3 age subgroups (P=0.016), and the ≥80 years group presented higher DBPCV than the 60-69 years group (P=0.044). Gender subgroup analysis demonstrated that females had higher SBP (P=0.000) and PP (P=0.000) than males, whereas males had higher DBP than females (P=0.000). No significant differences in the SBPCV, DBPCV, pulse pressure coefficient variation (PPCV) and mean arterial pressure coefficient variation (MAPCV) were found between males and females (P>0.05, for all).Conclusions Obvious seasonal blood pressure variability exists in community-dwelling elderly hypertensive populations. Blood pressure in winter and spring is higher than that in summer. Winter is a risk factor for increased blood pressure variability, and hypertensive patients aged ≥80 years have more prominent seasonal blood pressure variability.
    • Diagnosis and Treatment of Brain and Heart Comorbidity
  • Familial dolichoectatic vertebrobasilar aneurysm associated with PRKG1 gene variation: one case report
    WANG Na, HAN Xiao-dan, SHU Rui, ZHAO Wen-juan
    Chinese Journal of Contemporary Neurology and Neurosurgery. 2026, 26(9): 972-978. https://doi.org/10.3969/j.issn.1672-6731.2026.09.006
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    Objective To report a case of dolichoectatic vertebrobasilar aneurysm (DVBA) associated with PRKG1 gene variation, and to summarize its clinical, imaging and genetic features, so as to provide references for improving the recognition and precise diagnosis and treatment of this disease.Methods and Results A 65-year-old female patient was admitted to Department of Neurology, Tianjin Huanhu Hospital on January 14, 2026, presenting with transient dizziness for 10 months, which was aggravated with diplopia and deviation of the mouth angle for 11h. Cranial MRI showed acute cerebral infarction in the pons, multiple hemosiderin depositions in the bilateral cerebellum and white matter hyperintensities. Cervicocranial CTA showed tortuosity and elongation of the vertebrobasilar artery with aneurysmal dilatation of the basilar artery, as well as in-stent thrombosis after stent implantation. Coronary CTA showed aneurysmal dilatation of the coronary artery, and thoracic aortic CTA showed dilatation of the ascending and descending aorta. She had undergone stent implantation for a fusiform basilar artery aneurysm, but still experienced recurrent posterior circulation ischemic events after the procedure. Next-generation sequencing (NGS) showed that there was a splice-site heterozygous mutation c.1001+1G>A in the PRKG1 gene, and the patient was definitively diagnosed with DVBA associated with PRKG1 gene variation. After antiplatelet, lipid-lowering, antihypertensive and vestibular rehabilitation therapy, the patients' above symptoms were relieved. At 3-month follow-up after discharge, the modified Rankin Scale (mRS) was 1.Conclusions The splice-site heterozygous mutation c.1001+1G>A in PRKG1 gene is a novel pathogenic factor for familial DVBA, and the vascular damage is characterized by multi-segment involvement of intracranial, coronary and aortic arteries. For patients with early-onset, familial clustering or aggressive course of DVBA, genetic testing and family screening should be routinely performed, and integrated evaluation of cerebral and systemic large arteries as well as individualized treatment should be carried out.
  • Extensive cervical artery dissection resulting in cerebral infarction with orthostatic hypotensive syncope in puerperium: one case report
    YAN Lin-lin, MA Xin, DONG Jing
    Chinese Journal of Contemporary Neurology and Neurosurgery. 2026, 26(9): 979-987. https://doi.org/10.3969/j.issn.1672-6731.2026.09.007
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    Objective To summarize the clinical and imaging characteristics of a patient with extensive cervical artery dissection resulting in cerebral infarction with orthostatic hypotensive syncope during the puerperium, and to explore the potential pathogenic mechanisms by which anatomical variations, local mechanical factors, and puerperal physiological changes may be involved.Methods and Results A 42-year-old female patient was admitted to Xuanwu Hospital, Capital Medical University in July 8, 2025. The patient underwent cesarean section 10d before admission, and had a history of shoulder-neck massage before symptom onset. The main clinical manifestation was recurrent transient loss of consciousness associated with postural changes, accompanied by orthostatic hypotension, profuse sweating and reduced food intake. Laboratory tests showed elevated D-dimer and decreased protein S activity. Diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) map showed acute infarction in the right basal ganglia and semioval center. Cervical vascular ultrasound showed intramural hematoma-type dissection of the bilateral internal carotid arteries (ICA) and left vertebral artery (VA). Anatomical variants were also found, including high entry of bilateral VA into the transverse foramina, origin of the left VA from the aortic arch, and right carotid web. CTA showed that segments of the ICA and VA were adjacent to bony structures including the atlas lateral mass and temporal styloid process. After antithrombotic therapy, interventions to improve effective circulating blood volume, and supportive care, the patient's vascular stenosis improved significantly. No recurrent loss of consciousness or recurrent vascular events were observed during follow-up.Conclusions Anatomical variations, exposure to external mechanical forces on the neck, and physiological changes during the puerperium may collectively increase the susceptibility to cervical artery dissection. For patients presenting with orthostatic hypotensive syncope or unexplained cerebral infarction during the puerperium, great importance should be attached to the assessment of head and neck vessels. Multimodal imaging is highly valuable in identifying dissections, vascular variations and their relationships with surrounding bony structures.
    • Digit-Intelligent Neurosurgery
  • Application of artificial intelligence-based digital image simulation combined with mixed reality technology in precise minimally invasive surgery for gliomas in functional areas via natural sulcal spaces
    YANG Chen-long, CHEN Xiao-dong, YANG Jun
    Chinese Journal of Contemporary Neurology and Neurosurgery. 2026, 26(9): 988-995. https://doi.org/10.3969/j.issn.1672-6731.2026.09.008
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    Objective To carry out surgical training by means of artificial intelligence (AI)-based digital image simulation combined with mixed reality (MR) technology, improve the surgical methods for gliomas in functional areas, explore precise minimally invasive surgical strategies for navigating through natural sulcal spaces, and establish an efficient surgical training model for young physicians.Methods A total of 45 patients with gliomas in functional areas who underwent surgical resection at Peking University Third Hospital from March 2023 to January 2025. Preoperative MRI and thin-slice CT were performed to construct an AI-based 3D digital image simulation model. Young physicians (residents and attending physicians) analyzed anatomical details and planned surgical paths using this model. The accuracy of anatomical detail analysis and the consistency of surgical path planning were evaluated with the 5-point Likert scale. During surgery, MRI-based surgical navigation combined with microscopy and neuroelectrophysiological monitoring was adopted, and tumors were resected according to the optimized surgical path. National Institutes of Health Stroke Scale (NIHSS) was used to assess neurological function preoperatively, 7d postoperatively and one month postoperatively, respectively.Results In terms of anatomical analysis and surgical training outcomes, young physicians demonstrated significant progress in anatomical detail analysis and surgical path planning with the assistance of the AI-based 3D digital image simulation model. With the advancement of training, residents and attending physicians showed reduced time spent on anatomical detail analysis (P=0.000, 0.000) and increased accuracy score (P=0.000, 0.000), as well as shortened time for surgical path planning (P=0.000, 0.000) and improved consistency score (P=0.000, 0.000). Regarding surgical outcomes, the total tumor resection rate reached 100% (45/45). Neurological function was improved in 23 cases (51.11%), remained unchanged in 16 cases (35.56%), and deteriorated in 6 cases (13.33%). Compared with the preoperative status, motor function scores were improved at 7d postoperatively (P=0.037), and both motor function (P=0.000) and language function scores (P=0.005) were improved at one month postoperatively.Conclusions AI-based digital image simulation combined with mixed reality technology shows great potential and advantages in anatomical detail analysis and surgical path planning for functional area gliomas surgery. It can provide young physicians with comprehensive and intuitive anatomical information, help them quickly understand and master complex anatomical structures, and formulate more rational surgical paths, thus offering an effective solution to the limitations of traditional surgical training models. In addition, the precise minimally invasive surgical strategy of navigating through natural sulcal spaces is conducive to improving surgical outcomes and protecting neurological function, which is worthy of clinical promotion and application.
    • Neurological Rare Diseases
  • Distal hereditary motor neuropathy caused by DNAJB2 gene variation: one case report
    FENG Bin, WU Rui-peng
    Chinese Journal of Contemporary Neurology and Neurosurgery. 2026, 26(9): 996-1002. https://doi.org/10.3969/j.issn.1672-6731.2026.09.009
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    Objective To report a case of distal hereditary motor neuropathy (dHMN) caused by DNAJB2 gene variation and review the relevant literature, to broaden the spectrum of gene mutation and clinical phenotype of DNAJB2 gene.Methods and Results A 39-year-old man with progressive weakness in both lower limbs and muscle atrophy was included, his parents were close relatives. EMG indicated damage to anterior horn cells of the spinal cord with or without tibial nerve damage. Whole exome sequencing (WES) revealed patient carried a homozygous splice mutation of DNAJB2 gene c.65+1_65+3delinsTTT. This mutation had not been recorded and was a new mutation site for dHMN. The patient was treated with vitamin B and citicoline, his symptoms did not improved.Conclusions dHMN is a rare hereditary peripheral neuropathy, EMG and genetic testing are particularly important for diagnosis. This case first reported c.65+1_65+3delinsTTT variant of DNAJB2 gene and enriched mutational spectrum and clinical phenotype spectrum of DNAJB2 gene, and provides value for subsequent research of this disease.
    • Basic Research
  • Study on the mechanism of quinolinic phosphoribosyltransferase regulating the biological behaviors of glioma cells
    QIN Hu, ZHENG Yi-tong, LIU Wen, MAIMAITI Aierpati, LI Ya-bin, WANG Yong-xin
    Chinese Journal of Contemporary Neurology and Neurosurgery. 2026, 26(9): 1003-1012. https://doi.org/10.3969/j.issn.1672-6731.2026.09.010
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    Objective To investigate the effects of quinolinic phosphoribosyltransferase (QPRT) on the proliferation, migration and invasion of glioma cells, and to preliminarily elucidate its potential molecular regulatory mechanisms.Methods Stable QPRT knockdown and overexpression glioma cell lines (U87MG and U251MG) were established using lentiviral transduction. Western blotting was performed to detect the relative expression of QPRT protein and key enzymes involved in the nicotinamide adenine dinucleotide (NAD) biosynthesis pathway, including nicotinate phosphoribosyltransferase 1 (NAPRT1), nicotinamide phosphoribosyltransferase (NAMPT), nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1), and NAD synthetase 1 (NADSYN1). Cell proliferation was assessed by CCK-8 assay, while cell migration and invasion were evaluated using wound healing assay and Transwell migration and invasion assays.Results Western blotting showed that, compared with knockdown control group, in U87MG cells, QPRT knockdown significantly increased NAPRT1 (t=3.431,P=0.027) and NMNAT1 (t=4.045,P=0.016) expression, and decreased NADSYN1 expression (t=29.715,P=0.000). Compared with overexpression control group, QPRT overexpression decreased NAPRT1 (t=8.970,P=0.009) and NMNAT1 (t=13.290,P=0.000) expression, and increased NADSYN1 expression (t=2.886,P=0.045). In U251MG cells, QPRT knockdown increased NMNAT1 expression (t=2.808,P=0.038) and decreased NADSYN1 expression (t=3.651,P=0.022), whereas QPRT overexpression decreased NMNAT1 expression (t=14.798,P=0.000) and increased NADSYN1 expression (t=4.314,P=0.013). Functionally, compared with knockdown control group, QPRT knockdown significantly reduced cell proliferation (U87MG:t=13.910,P=0.000; U251MG:t=6.118,P=0.004), migration (U87MG:t=5.750,P=0.005; U251MG:t=4.094,P=0.015), and the number of cells penetrating the membrane (migration:t=3.566,P=0.007;t=6.329,P=0.003; invasion:t=7.820,P=0.000;t=11.928,P=0.000). Conversely, compared with overexpression control group, QPRT overexpression significantly enhanced cell proliferation (U87MG:t=2.883,P=0.045; U251MG:t=4.094,P=0.015), migration (U87MG:t=4.908,P=0.008; U251MG:t=17.503,P=0.000), and the number of cells penetrating the membrane (migration:t=12.818,P=0.000;t=6.426,P=0.003; invasion:t=11.605,P=0.000;t=18.852,P=0.000).Conclusions QPRT promotes glioma cell proliferation, migration and invasion by regulating the NAD+biosynthesis pathway, plays an important role in the malignant progression of glioma, and may serve as a potential therapeutic target.
    • Clinical Study
  • Comparative analysis of imaging characteristics and vascular recanalisation between internal carotid artery dissection and vertebral artery dissection
    DAI Chen-yang, TANG Yuan-yuan, WANG Lu, LI Lin-lin, WEI Qiang, WANG Kai
    Chinese Journal of Contemporary Neurology and Neurosurgery. 2026, 26(9): 1013-1019. https://doi.org/10.3969/j.issn.1672-6731.2026.09.011
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    Objective To compare the differences in clinical presentation, imaging characteristics, and vascular recanalisation outcomes between internal carotid artery dissection (ICAD) and vertebral artery dissection (VAD).Methods A total of 50 patients diagnosed and treated for cervical arterial dissection (including 27 ICAD cases and 23 VAD cases) at The First Affiliated Hospital of Anhui Medical University between February 2017 and February 2025 were enrolled. Clinical data were collected, with imaging examinations documenting the location, side, extent of involvement, type of dissection, and degree of stenosis in responsible arteries. Neurological functional outcomes were assessed at discharge using the modified Rankin Scale (mRS). At the 3-month follow-up, imaging was reassessed to evaluate vascular recanalization and to document any adverse events, including new transient ischemic attacks, ischemic strokes, or symptomatic intracranial hemorrhages.Results Compared to VAD group, ICAD group had a higher male distribution (χ2=11.434,P=0.001), with more frequent initial presentations of limb weakness (χ2=6.799,P=0.009) and language impairment (χ2=7.034,P=0.008). National Institutes of Health Stroke Scale (NIHSS) score at admission was higher in ICAD group (Z= -2.545,P=0.011), while dizziness was less common (χ2=9.972,P=0.002). Radiologically, all ICAD cases were unilateral, whereas 30.43% of VAD cases were bilateral (Fisher's exact probability:P=0.005). The proportion of patients with favourable neurological outcome (mRS score≤2) showed no statistically significant difference between the 2 groups [77.78% (21/27) vs. 91.30% (21/23); χ2=0.834,P=0.361]. At the 3-month follow-up, all 12 patients who underwent endovascular treatment achieved complete recanalization. Among patients who received conservative medical therapy, the overall number of recanalization was similar between the ICAD and VAD groups (12/15 vs. 15/18; Fisher's exact probability:P=1.000).Conclusions Significant differences exist between ICAD and VAD in gender distribution, clinical presentation, and imaging characteristics. Both medical therapy and endovascular treatment yielded favourable short-term recanalisation, with medical therapy being a viable first-line option for stable patients.
  • The efficacy and safety of LVIS stent in the treatment of severe symptomatic vertebrobasilar artery stenosis
    HU Kai, ZHENG Zi-ming, DENG Min, XIE Bing
    Chinese Journal of Contemporary Neurology and Neurosurgery. 2026, 26(9): 1020-1026. https://doi.org/10.3969/j.issn.1672-6731.2026.09.012
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    Objective To evaluate the efficacy and safety of LVIS stent for severe symptomatic vertebrobasilar artery stenosis.Methods A total of 44 patients with severe symptomatic vertebrobasilar artery stenosis who were admitted to Zhongshan City People's Hospital, from January 2020 to December 2022 were enrolled. All patients underwent LVIS stent implantation following balloon pre-dilation. According to the location of the lesion, the patients were divided into a vertebral artery stenosis group (VA group,n=26) and a basilar artery stenosis group (BA group,n=18). Before and after stent implantation, the degree and length of stenosis of responsible artery were measured by DSA, the degree of neurological deficit was evaluated by National Institutes of Health Stroke Scale (NIHSS), and the incidence of complications during the operation, short-term postoperative period (within 24h after surgery) and follow-up period was recorded.Results All 44 patients successfully completed the LVIS stent implantation procedure, with a 100% surgical success rate. The degree of stenosis of the responsible artery at 30d after stent implantation was lower (F=3384.906,P=0.000), the stenosis length was shorter (F=158.036,P=0.000), and the NIHSS score was lower (F=410.246,P=0.000) in both group than those of before stent implantation. BA group exhibited higher NIHSS score than VA group (F=14.713,P=0.000). The overall complication rates during the operation, short-term postoperative period and follow-up period were 6.82% (3/44), 4.55% (2/44) and 17.07% (7/41), respectively. There was no statistically significant difference in the complication rates between the 2 groups (P>0.05, for all).Conclusions The LVIS stent has shown certain therapeutic effects in improving vertebrobasilar artery stenosis and neurological function in the short term, and the incidence of complications is within an acceptable range.
  • Analysis of factors influencing comfort in patients with cerebrovascular disease undergoing cerebral endovascular intervention with early ambulation
    PANG Ke, SHEN Ke-fan, LI Ming-yao, ZHANG Kai, ZHANG Xiao-ping, MA Ning
    Chinese Journal of Contemporary Neurology and Neurosurgery. 2026, 26(9): 1027-1034. https://doi.org/10.3969/j.issn.1672-6731.2026.09.013
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    Objective To evaluate the effect of early ambulation on comfort after cerebral endovascular intervention via femoral artery puncture using the General Comfort Questionnaire (GCQ).Methods A total of 525 patients with cerebrovascular disease who underwent cerebral endovascular intervention procedure via femoral artery puncture at Beijing Tiantan Hospital, Capital Medical University, between June 2023 and January 2024 were enrolled. Postoperative time to first ambulation and complications were recorded. Comfort was assessed using the GCQ. Propensity score matching (1∶4) balanced covariates. Generalized univariate and multivariate linear regression analyses were used to assess the association between early ambulation and postoperative GCQ score.Results Patients were categorized into early (≤8h,n=46) and delayed (>8h,n=184) ambulation groups based on postoperative ambulation time and propensity score matching. The GCQ score in early ambulation group were higher than those in delayed ambulation group (Z= -3.373,P=0.000). Generalized multivariable linear regression analysis demonstrated that early ambulation was associated with higher GCQ score [exp (β)= 1.042, 95%CI: 1.024-1.061;P=0.000].Conclusions Early ambulation significantly improves comfort among patients with cerebrovascular disease undergoing cerebral endovascular intervention via femoral artery puncture, without increasing the risk of puncture site complications.
  • Analysis of risk factors for secondary hydrocephalus after posterior fossa decompression
    CHEN Xiao-chen, SUN Dong-dong, FENG Ke-k
    Chinese Journal of Contemporary Neurology and Neurosurgery. 2026, 26(9): 1035-1039. https://doi.org/10.3969/j.issn.1672-6731.2026.09.014
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    Objective To investigate the risk factors for secondary hydrocephalus after posterior fossa decompression.Methods A total of 43 patients who underwent posterior fossa decompression in Tianjin Huanhu Hospital from January 2021 to December 2022 were selected. There were 25 cases (58.14%) of cerebellar tonsillar herniation malformation, 12 cases (27.91%) of cerebellar infarction, 4 cases (9.30%) of cerebellar hemorrhage, one case (2.33%) of brain stem hemorrhage, and one case (2.33%) of posterior inferior cerebellar artery aneurysm rupture. They were divided into hydrocephalus group (n=12) and non-hydrocephalus group (n=31) according to whether secondary hydrocephalus occurred at 3 months after surgery. Univariate and multivariate Logistic regression analyses were used to screen the risk factors of secondary hydrocephalus after posterior fossa decompression.Results Logistic regression analysis showed that the occurrence of fluid accumulation under the flap after posterior fossa decompression was risk factor for postoperative secondary hydrocephalus (OR=8.062, 95%CI: 1.521-6.819;P=0.046).Conclusions The occurrence of fluid accumulation under the flap after posterior fossa decompression is risk factor for postoperative secondary hydrocephalus. Avoiding the occurrence of fluid accumulation under the flap can effectively prevent hydrocephalus.
    • Review
  • Research progress of machine learning technology in the diagnosis and treatment of severe aneurysmal subarachnoid hemorrhage
    MA Shuai-tao, LI Ang, MA Xin-chen, SHI Yi, FENG Guang, HAN Bing-sha
    Chinese Journal of Contemporary Neurology and Neurosurgery. 2026, 26(9): 1040-1045. https://doi.org/10.3969/j.issn.1672-6731.2026.09.015
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    Severe aneurysmal subarachnoid hemorrhage (SaSAH) has an extremely high rate of disability and mortality. Traditional diagnostic methods have limitations such as insufficient data processing capabilities and reliance on empirical decision-making in achieving precise diagnosis, complication warning, and prognosis assessment. In recent years, the wide application of machine learning (ML) technology in the medical field has opened up new paths for the precise diagnosis and treatment of SaSAH. This article systematically reviews the basic concepts of ML technology, focuses on elaborating its latest research progress in the early diagnosis, complication prediction, treatment plan optimization, and prognosis assessment of SaSAH, and also analyzes a series of challenges such as data bias and model interpretability encountered in the current application process. The aim is to provide theoretical references for building a precise and effective treatment system for SaSAH.
  • The association and mechanism research progress between cerebellum and non-motor symptoms of Parkinson's disease
    FENG Yuan-yuan, CHEN Yi, ZHANG Hai-ying, ZHANG Li
    Chinese Journal of Contemporary Neurology and Neurosurgery. 2026, 26(9): 1046-1051. https://doi.org/10.3969/j.issn.1672-6731.2026.09.016
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    Parkinson's disease (PD) patients often experience non-motor symptoms such as cognitive impairment, sleep disorders and neuropsychiatric symptoms, which severely impair their quality of life. In recent years, increasing attention has been paid to the role of the cerebellum in the non-motor symptoms of PD. Structural and functional changes in the cerebellum of PD patients are closely associated with the onset and progression of these non-motor symptoms. This review summarizes the current advances in the relationship between cerebellum and non-motor symptoms in PD, with the aim of further elucidating the pathophysiological mechanisms underlying these symptoms and providing a theoretical basis for the development of novel diagnostic and therapeutic strategies.
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