Progress on non-invasive electrical and magnetic neuromodulation therapy for cognitive impairment in posttraumatic stress disorder

doi:10.3969/j.issn.1672-6731.2026.01.005

Abstract

Abstract: Posttraumatic stress disorder (PTSD) is a severe mental disorder triggered by traumatic events. Its core clinical symptoms include intrusive memories, avoidance behaviors, negative alterations in mood and cognitive disorder, and hyperarousal. These symptoms are closely associated with aberrant neural circuitry involving the amygdala, hippocampus and prefrontal cortex. However, current pharmacological and psychological interventions are constrained by limited efficacy, poor compliance, and undesirable side effects. Given the high safety, strong reproducibility, and high patient acceptance, non-invasive electrical and magnetic neuromodulation techniques have emerged as a research focus for improving cognitive impairment in PTSD. This paper reviews the advancements in applying transcranial electrical stimulation (TES) and transcranial magnetic stimulation (TMS) to alleviate cognitive impairment in PTSD, and discusses the potential value of their combined use with psychological therapies. It aims to provide new perspectives for the clinical application of neuromodulation technique in treating cognitive impairment in PTSD.

Key words: Stress disorders, post-traumatic, Cognition disorders, Electric stimulation therapy, Transcranial magnetic stimulation, Review

摘要： 创伤后应激障碍是严重创伤性事件引起的精神障碍，主要临床症状包括侵入性回忆、回避行为、认知功能和情绪障碍、过度警觉，与包括杏仁核、海马和前额叶在内的脑网络异常模式密切相关。目前尚无有效治疗方法，药物治疗和心理疗法效果有限，患者依从性差，且常伴不良反应或症状残留。非侵入性电磁神经调控技术因安全性高、可重复性强、患者接受度高等优势，成为改善创伤后应激障碍认知损害的研究热点。本文综述经颅电刺激和经颅磁刺激在创伤后应激障碍认知损害中的应用进展，总结其与心理疗法联合应用的潜在价值，以期为神经调控用于创伤后应激障碍认知损害的临床治疗提供新的思路。

关键词: 应激障碍,创伤后, 认知障碍, 电刺激疗法, 经颅磁刺激, 综述

CLC Number:

R741
R651

JIN Zhuo, REN Xiao-xin, WANG Hao-ting, QIAO Yi-jing, ZHAO Yu-chao, ZHENG Chen-guang. Progress on non-invasive electrical and magnetic neuromodulation therapy for cognitive impairment in posttraumatic stress disorder[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2026, 26(1): 30-39.

靳卓, 任小欣, 王浩婷, 乔羿静, 赵玉超, 郑晨光. 非侵入性电磁神经调控治疗创伤后应激障碍认知损害研究进展[J]. 中国现代神经疾病杂志, 2026, 26(1): 30-39.

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https://journal11.magtechjournal.com/cjcnn/EN/Y2026/V26/I1/30

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