Innovative research on medicine-engineering convergence in neuromodulation

doi:10.3969/j.issn.1672-6731.2026.01.002

Abstract

Abstract: Nervous system diseases have emerged as a leading cause of health loss and disability worldwide, and are increasingly recognized as a global public health challenge. In response to this challenge, the development and application of neuroscience technologies for treating nervous system diseases are of paramount importance. As a biomedical engineering technology characterized by multidisciplinary integration and medicine-engineering convergence, neuromodulation technique has become one of the most rapidly advancing fields in modern medicine. This article systematically reviews the principles of neuromodulation, its technological innovations, and progress in clinical applications, while also offering perspectives on future directions to promote the innovative development and clinical translation of neuromodulation technique.

Key words: Electric stimulation therapy, Transcranial magnetic stimulation, Ultrasonic therapy, Optogenetics, Nervous system diseases, Medicine-engineering convergence (not in MeSH), Review

摘要： 神经系统疾病已成为全球健康损失和致残的主要原因，越来越被视为全球公共卫生挑战。为了应对这挑战，开发和应用神经科学技术治疗神经系统疾病至关重要，作为多学科交叉、医工融合的生物医学工程技术，神经调控成为当前医学发展最快的领域之一。因此，本文对神经调控原理、技术创新特点和临床应用进展进行系统总结，并展望其未来发展方向，以期推动神经调控技术的创新发展与临床转化。

关键词: 电刺激疗法, 经颅磁刺激, 超声疗法, 光遗传学, 神经系统疾病, 医工融合(非MeSH词), 综述

CLC Number:

R741
TP183

MING Dong. Innovative research on medicine-engineering convergence in neuromodulation[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2026, 26(1): 8-12.

明东. 神经调控医工融合创新研究[J]. 中国现代神经疾病杂志, 2026, 26(1): 8-12.

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https://journal11.magtechjournal.com/cjcnn/EN/Y2026/V26/I1/8

References

[1] Sivanesan E, North RB, Russo MA, Levy RM, Linderoth B, Hayek SM, Eldabe S, Lempka SF. A definition of neuromodulation and classification of implantable electrical modulation for chronic pain[J]. Neuromodulation, 2024, 27: 1-12.
[2] Deer TR. Atlas of implantable therapies for pain management [M]. New York: Springer, 2011: 6.
[3] Krames E, Peckham PH, Rezai AR. Neuromodulation: comprehensive textbook of principles, technologies, and therapies[M]. 2nd ed. Cambridge: Academic Press, 2018: ⅹⅷ-XI X.
[4] Feigin VL, Vos T, Nichols E, Owolabi MO, Carroll WM, Dichgans M, Deuschl G, Parmar P, Brainin M, Murray C. The global burden of neurological disorders: translating evidence into policy[J]. Lancet Neurol, 2020, 19:255-265.
[5] GBD 2021 Nervous System Disorders Collaborators. Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021[J]. Lancet Neurol, 2024, 23:344-381.
[6] Zhang C, Yang X, Wan D, Ma Q, Yin P; GBD 2021 China Neurological Disorders Collaborators; Zhou M, Hao J. Burden of neurological disorders in China and its provinces, 1990-2021: findings from the global burden of disease study 2021[J]. Med, 2025, 6:100692.
[7] Li ZJ, Zhang LB, Chen YX, Hu L. Advancements and challenges in neuromodulation technology: interdisciplinary opportunities and collaborative endeavors[J]. Sci Bull (Beijing), 2023, 68:1978-1982.
[8] Karatum O, Han M, Erdogan ET, Karamursel S, Nizamoglu S. Physical mechanisms of emerging neuromodulation modalities [J]. J Neural Eng, 2023, 20:031001.
[9] Yuk H, Lu B, Zhao X. Hydrogel bioelectronics[J]. Chem Soc Rev, 2019, 48:1642-1667.
[10] Barker AT, Jalinous R, Freeston IL. Non-invasive magnetic stimulation of human motor cortex[J]. Lancet, 1985, 1: 1106-1107.
[11] Blackmore J, Shrivastava S, Sallet J, Butler CR, Cleveland RO. Ultrasound neuromodulation: a review of results, mechanisms and safety[J]. Ultrasound Med Biol, 2019, 45:1509-1536.
[12] Boyden ES, Zhang F, Bamberg E, Nagel G, Deisseroth K. Millisecond-timescale, genetically targeted optical control of neural activity[J]. Nat Neurosci, 2005, 8:1263-1268.
[13] Di Passa AM, Dabir M, Fein A, Khoshroo S, McIntyre-Wood C, Marsden E, MacKillop E, De Jesus J, MacKillop J, Duarte D. Clinical efficacy of deep transcranial magnetic stimulation in psychiatric and cognitive disorders: protocol for a systematic review[J]. JMIR Res Protoc, 2023, 12:e45213.
[14] Grossman N, Bono D, Dedic N, Kodandaramaiah SB, Rudenko A, Suk HJ, Cassara AM, Neufeld E, Kuster N, Tsai LH, Pascual-Leone A, Boyden ES. Noninvasive deep brain stimulation via temporally interfering electric fields[J]. Cell, 2017, 169:1029-1041.
[15] Kim R, Liu Y, Zhang J, Xie C, Luan L. Towards precise synthetic neural codes: high-dimensional stimulation with flexible electrodes[J]. Npj Flex Electron, 2025, 9:68.
[16] Zhou S, Gao Y, Li R, Wang H, Zhang M, Guo Y, Cui W, Brown KG, Han C, Shi L, Liu H, Zhang J, Li Y, Meng F. Neurosurgical robots in China: state of the art and future prospect[J]. iScience, 2023, 26:107983.
[17] Qi Z, Liu H, Jin F, Wang Y, Lu X, Liu L, Yang Z, Fan L, Song M, Zuo N, Jiang T. A wearable repetitive transcranial magnetic stimulation device[J]. Nat Commun, 2025, 16:2731.
[18] Oehrn CR, Cernera S, Hammer LH, Shcherbakova M, Yao J, Hahn A, Wang S, Ostrem JL, Little S, Starr PA. Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson's disease: a blinded randomized feasibility trial [J]. Nat Med, 2024, 30:3345-3356.
[19] Denison T, Morrell MJ. Neuromodulation in 2035: the neurology future forecasting series[J]. Neurology, 2022, 98:65-72.
[20] Baker KB, Plow EB, Nagel S, Rosenfeldt AB, Gopalakrishnan R, Clark C, Wyant A, Schroedel M, Ozinga J 4th, Davidson S, Hogue O, Floden D, Chen J, Ford PJ, Sankary L, Huang X, Cunningham DA, DiFilippo FP, Hu B, Jones SE, Bethoux F, Wolf SL, Chae J, Machado AG. Cerebellar deep brain stimulation for chronic post-stroke motor rehabilitation: a phase Ⅰ trial[J]. Nat Med, 2023, 29:2366-2374.
[21] Alfihed S, Majrashi M, Ansary M, Alshamrani N, Albrahim SH, Alsolami A, Alamari HA, Zaman A, Almutairi D, Kurdi A, Alzaydi MM, Tabbakh T, Al-Otaibi F. Non-invasive brain sensing technologies for modulation of neurological disorders [J]. Biosensors (Basel), 2024, 14:335.
[22] Bhattacharya A, Mrudula K, Sreepada SS, Sathyaprabha TN, Pal PK, Chen R, Udupa K. An overview of noninvasive brain stimulation: basic principles and clinical applications[J]. Can J Neurol Sci, 2022, 49:479-492.
[23] Luo Y, Yang FY, Lo RY. Application of transcranial brain stimulation in dementia[J]. Tzu Chi Med J, 2023, 35:300-305.
[24] Koch G, Altomare D, Benussi A, Bréchet L, Casula EP, Dodich A, Pievani M, Santarnecchi E, Frisoni GB. The emerging field of non-invasive brain stimulation in Alzheimer's disease[J]. Brain, 2024, 147:4003-4016.
[25] Riis TS, Feldman DA, Vonesh LC, Brown JR, Solzbacher D, Kubanek J, Mickey BJ. Durable effects of deep brain ultrasonic neuromodulation on major depression: a case report[J]. J Med Case Rep, 2023, 17:449.
[26] Qin PP, Jin M, Xia AW, Li AS, Lin TT, Liu Y, Kan RL, Zhang BB, Kranz GS. The effectiveness and safety of low-intensity transcranial ultrasound stimulation: a systematic review of human and animal studies[J]. Neurosci Biobehav Rev, 2024, 156:105501.
[27] Chinese Society of Neurogenetics. Chinese expert consensus on the diagnosis and treatment of hereditary ataxia 2024[J]. Zhonghua Shen Jing Ke Za Zhi, 2024, 57:315-325.[中华医学会神经病学分会神经遗传学组. 中国遗传性共济失调诊治专家共识2024[J]. 中华神经科杂志, 2024, 57:315-325.]

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