Application of PET imaging in the diagnosis and prognosis prediction of autoimmune encephalitis

doi:10.3969/j.issn.1672-6731.2025.12.002

Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2025, Vol. 25 ›› Issue (12): 1095-1106. doi: 10.3969/j.issn.1672-6731.2025.12.002

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Application of PET imaging in the diagnosis and prognosis prediction of autoimmune encephalitis

Ning WANG¹, Yue-qian SUN¹, Qun WANG¹^,²^,³^,⁴^,*()

1. Center of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
2. Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450046, He'nan, China
3. China National Clinical Research Center for Neurological Diseases, Beijing 100070, China
4. Beijing Institute of Brain Disorders, Beijing 100069, China

Received:2025-11-02 Online:2025-12-25 Published:2026-01-08
Contact: Qun WANG
Supported by:
Capital Health Research and Development of Special Project(首发2024-1-2041); the National Natural Science Foundation of China(82371449); the National Natural Science Foundation of China(82501734); the National Natural Science Foundation of China(U24A20695); National Key Research and Development Program of China "Common Disease Prevention and Control Research" Key Project(2022YFC2503800); China Postdoctoral Science Foundation(2024M762180)

PET显像在自身免疫性脑炎诊断与预后预测中的应用

王宁¹, 孙越乾¹, 王群¹^,²^,³^,⁴^,*()

1. 100070 首都医科大学附属北京天坛医院神经病学中心
2. 450046 郑州大学第一附属医院神经内科
3. 100070 北京, 国家神经系统疾病临床医学研究中心
4. 100069 北京脑重大疾病研究院

通讯作者: 王群
基金资助:
首都卫生发展科研专项(首发2024-1-2041); 国家自然科学基金资助项目(82371449); 国家自然科学基金资助项目(82501734); 国家自然科学基金资助项目(U24A20695); 国家重点研发计划“常见多发病防治研究”重点专项(2022YFC2503800); 中国博士后科学基金资助项目(2024M762180)

Abstract

Abstract:

PET imaging plays a crucial role in the diagnosis and management of autoimmune encephalitis (AE). By detecting the distribution of radiotracers, PET provides a direct visualization of cerebral metabolic activity, revealing distinct metabolic patterns associated with different types of AE. Furthermore, it allows for effective monitoring of disease progression and therapeutic response, offering robust support for clinical decision-making. This review aims to elucidate the cerebral ¹⁸F-FDG PET metabolic patterns in AE associated with various antibodies, and to discuss the applications of other emerging PET tracers, with the goal of advancing the precise diagnosis and treatment of this condition.

Key words: Encephalitis, Autoimmune diseases of the nervous system, Anti-N-methyl-D-aspartate receptor encephalitis, Positron-emission tomography, Tau proteins, Review

摘要：

PET显像在自身免疫性脑炎的诊断与治疗过程中具有重要价值，可以借助检测放射性示踪剂在脑内分布，直观反映大脑代谢活动，呈现不同抗体类型自身免疫性脑炎代谢变化模式；还可以对疾病进展和治疗效果进行有效监测，为临床决策提供有力依据。本文拟阐述不同抗体自身免疫性脑炎¹⁸F-FDG PET代谢模式，以及其他新型PET技术在自身免疫性脑炎中的应用，以期有助于自身免疫性脑炎的精准诊断与治疗。

关键词: 脑炎, 神经系统自身免疫疾病, 抗N-甲基-D-门冬氨酸受体脑炎, 正电子发射断层显像术, tau蛋白质类, 综述

Ning WANG, Yue-qian SUN, Qun WANG. Application of PET imaging in the diagnosis and prognosis prediction of autoimmune encephalitis[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2025, 25(12): 1095-1106.

王宁, 孙越乾, 王群. PET显像在自身免疫性脑炎诊断与预后预测中的应用[J]. 中国现代神经疾病杂志, 2025, 25(12): 1095-1106.

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References 108

1	Guasp M , Dalmau J . Autoimmune encephalitis. Med Clin North Am, 2025, 109: 443- 461. doi: 10.1016/j.mcna.2024.09.001
2	Seery N , Wesselingh R , Beech P , Broadley J , Griffith S , Rushen T , Beharry J , Tan C , Chiniforoush N , McLaughlin L , Ter Horst L , Forcadela M , Tan T , Kazzi C , Nesbitt C , Buzzard K , Duncan A , Halliday A , D'Souza W , Tran Y , Van Der Walt A , Skinner G , Swayne A , Malpas CB , Brodtmann A , Gillis D , Taylor B , Butler EG , Kalincik T , Seneviratne U , Macdonell R , Blum S , Ramanathan S , Reddel SW , Hardy TA , O'Brien TJ , Sanfilippo P , Butzkueven H , Monif M , Australian Autoimmune Encephalitis Consortium . Multimodal prognostication of autoimmune encephalitis: an Australian autoimmune encephalitis consortium study. J Neurol, 2025, 272: 361. doi: 10.1007/s00415-025-13069-1
3	Heine J , Prüss H , Bartsch T , Ploner CJ , Paul F , Finke C . Imaging of autoimmune encephalitis: relevance for clinical practice and hippocampal function. Neuroscience, 2015, 309: 68- 83. doi: 10.1016/j.neuroscience.2015.05.037
4	Ball C , Fisicaro R , Morris L 3rd , White A , Pacicco T , Raj K , Agarwal A , Lee WC , Yu FF . Brain on fire: an imaging-based review of autoimmune encephalitis. Clin Imaging, 2022, 84: 1- 30. doi: 10.1016/j.clinimag.2021.12.011
5	Probasco JC , Solnes L , Nalluri A , Cohen J , Jones KM , Zan E , Javadi MS , Venkatesan A . Abnormal brain metabolism on FDG-PET/CT is a common early finding in autoimmune encephalitis. Neurol Neuroimmunol Neuroinflamm, 2017, 4: e352. doi: 10.1212/NXI.0000000000000352
6	Kalra S , Tripathi M , Tripathi M , Sonar RS , Pandey AK , Jaleel J , Singh RK , Kumar P , Damle NA , Bal C . Role of FDG PET/CT in definitive and presumed autoimmune encephalitis. Nucl Med Commun, 2024, 45: 121- 127. doi: 10.1097/MNM.0000000000001790
7	Wei YC , Tseng JR , Wu CL , Su FC , Weng WC , Hsu CC , Chang KH , Wu CF , Hsiao IT , Lin CP . Different FDG-PET metabolic patterns of anti-AMPAR and anti-NMDAR encephalitis: case report and literature review. Brain Behav, 2020, 10: e01540. doi: 10.1002/brb3.1540
8	Bordonne M , Chawki MB , Doyen M , Kas A , Guedj E , Tyvaert L , Verger A . Brain ¹⁸F-FDG PET for the diagnosis of autoimmune encephalitis: a systematic review and a meta-analysis. Eur J Nucl Med Mol Imaging, 2021, 48: 3847- 3858. doi: 10.1007/s00259-021-05299-y
9	Maudes E , Planagumà J , Marmolejo L , Radosevic M , Serafim AB , Aguilar E , Sindreu C , Landa J , García-Serra A , Mannara F , Cunquero M , Smit A , Milano C , Peixoto-Moledo P , Guasp M , Ruiz-García R , Gray SM , Spatola M , Loza-Alvarez P , Sabater L , Matute C , Dalmau J . Neuro-immunobiology and treatment assessment in a mouse model of anti-NMDAR encephalitis. Brain, 2025, 148: 2023- 2037. doi: 10.1093/brain/awae410
10	de Bruijn MAAM , Leypoldt F , Dalmau J , Lee ST , Honnorat J , Clardy SL , Irani SR , Easton A , Kunchok A , Titulaer MJ . Autoimmune encephalitis. Nat Rev Dis Primers, 2025, 11: 65. doi: 10.1038/s41572-025-00650-1
11	Ge J , Deng B , Guan Y , Bao W , Wu P , Chen X , Zuo C . Distinct cerebral ¹⁸F-FDG PET metabolic patterns in anti-N-methyl-D-aspartate receptor encephalitis patients with different trigger factors. Ther Adv Neurol Disord, 2021, 14: 1756286421995635. doi: 10.1177/1756286421995635
12	Dalmau J , Gleichman AJ , Hughes EG , Rossi JE , Peng X , Lai M , Dessain SK , Rosenfeld MR , Balice-Gordon R , Lynch DR . Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol, 2008, 7: 1091- 1098. doi: 10.1016/S1474-4422(08)70224-2
13	Cleaver J , Chungath R , Gimson A , Strippel C , Ceronie B , Soleimani B , Johnson T , Muscal E , Fisher K , Jiang Y , Erickson TA , Murray KO , Hovet STF , Poulsen CA , Magnussen AS , Dumez P , Ronca S , Häusler M , Quade A , Swayne A , Blaabjerg M , Nissen M , Sandweiss AJ , Honnorat J , Dale R , Lim M , Eyre M , Nosadini M , Handunnetthi L , Irani SR , Handel AE . Clinical phenotype and outcomes in autoimmune encephalitis after herpes simplex virus encephalitis: a systematic review and meta-analysis. J Infect, 2025, 91: 106566. doi: 10.1016/j.jinf.2025.106566
14	Wang Y , Zhou Q , Dai Z , Qiu Y , Zhou H , Feng L , Zhao J . Clinical and brain MRI characteristics of patients with anti-N-methyl-D-aspartate receptor encephalitis: a 10-year retrospective study. Eur Neurol, 2025, 88: 71- 81.
15	Florance NR , Davis RL , Lam C , Szperka C , Zhou L , Ahmad S , Campen CJ , Moss H , Peter N , Gleichman AJ , Glaser CA , Lynch DR , Rosenfeld MR , Dalmau J . Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents. Ann Neurol, 2009, 66: 11- 18. doi: 10.1002/ana.21756
16	Kerik-Rotenberg N , Diaz-Meneses I , Hernandez-Ramirez R , Muñoz-Casillas R , Reynoso-Mejia CA , Flores-Rivera J , Espinola-Nadurille M , Ramirez-Bermudez J , Aguilar-Palomeque C . A metabolic brain pattern associated with anti-N-methyl-D-aspartate receptor encephalitis. Psychosomatics, 2020, 61: 39- 48. doi: 10.1016/j.psym.2019.08.007
17	Yuan L , Mao G , Zhang Y , Xu Y , Chen Q , Shan B , Cui T , Ai L . Typical metabolic pattern of ¹⁸F-FDG PET in anti-NMDAR encephalitis in the acute and subacute phases and its correlation with T2 FLAIR-MRI features. BMC Neurosci, 2023, 24: 51. doi: 10.1186/s12868-023-00823-2
18	Nabizadeh F , Ramezannezhad E , Sardaripour A , Seyedi SA , Salehi N , Rezaeimanesh N , Naser Moghadasi A . [18F]FDG brain PET and clinical symptoms in different autoantibodies of autoimmune encephalitis: a systematic review. Neurol Sci, 2022, 43: 4701- 4718. doi: 10.1007/s10072-022-06094-9
19	Jha S , Nagaraj C , Kenchaiah R , Mahadevan A , Bhat M , Saini J , Netravathi M . FDG-PET in autoimmune encephalitis: utility, pattern of abnormalities, and correlation with autoantibodies. Ann Indian Acad Neurol, 2022, 25: 1122- 1129. doi: 10.4103/aian.aian_645_22
20	Yuan J , Guan H , Zhou X , Niu N , Li F , Cui L , Cui R . Changing brain metabolism patterns in patients with ANMDARE: serial ¹⁸F-FDG PET/CT findings. Clin Nucl Med, 2016, 41: 366- 370. doi: 10.1097/RLU.0000000000001164
21	Bergeret S , Birzu C , Meneret P , Giron A , Demeret S , Marois C , Cousyn L , Rozenblum L , Laurenge A , Alentorn A , Navarro V , Psimaras D , Kas A . Brain metabolic alterations in seropositive autoimmune encephalitis: an ¹⁸F-FDG PET study. Biomedicines, 2023, 11: 506. doi: 10.3390/biomedicines11020506
22	Zhang C , Hao Y , Huang G , Xin M , Bai S , Guan Y , Liu J . Hypometabolism of the left middle/medial frontal lobe on FDG-PET in anti-NMDA receptor encephalitis: comparison with MRI and EEG findings. CNS Neurosci Ther, 2023, 29: 1624- 1635. doi: 10.1111/cns.14125
23	Li G , Liu X , Yu T , Ren J , Wang Q . Positron emission tomography in autoimmune encephalitis: clinical implications and future directions. Acta Neurol Scand, 2022, 146: 708- 715. doi: 10.1111/ane.13717
24	Probasco JC , Solnes L , Nalluri A , Cohen J , Jones KM , Zan E , Javadi MS , Venkatesan A . Decreased occipital lobe metabolism by FDG-PET/CT: an anti-NMDA receptor encephalitis biomarker. Neurol Neuroimmunol Neuroinflamm, 2017, 5: e413.
25	Bacchi S , Franke K , Wewegama D , Needham E , Patel S , Menon D . Magnetic resonance imaging and positron emission tomography in anti-NMDA receptor encephalitis: a systematic review. J Clin Neurosci, 2018, 52: 54- 59. doi: 10.1016/j.jocn.2018.03.026
26	Dai Y , Zhu Z , Tang Y , Xiao L , Liu X , Zhang M , Xiao B , Hu K , Long L , Xie Y , Hu S . The clinical and predictive value of ¹⁸F-FDG PET/CT metabolic patterns in a clinical Chinese cohort with autoimmune encephalitis. CNS Neurosci Ther, 2024, 30: e14821. doi: 10.1111/cns.14821
27	Novy J , Allenbach G , Bien CG , Guedj E , Prior JO , Rossetti AO . FDG-PET hyperactivity pattern in anti-NMDAR encephalitis. J Neuroimmunol, 2016, 297: 156- 158. doi: 10.1016/j.jneuroim.2016.05.016
28	Kosek S , Kilsved E , Danfors T , Cunningham JL , Pavel R , Rostedt Punga A , Burman J , Fällmar D . Regional metabolic abnormalities in autoimmune encephalitis: a Meta-analysis of 498 cases with brain FDG PET. Clin Nucl Med, 2025, 50: 208- 213. doi: 10.1097/RLU.0000000000005574
29	Lagarde S , Lepine A , Caietta E , Pelletier F , Boucraut J , Chabrol B , Milh M , Guedj E . Cerebral (18) fluorodeoxy-glucose positron emission tomography in paediatric anti N-methyl-D-aspartate receptor encephalitis: a case series. Brain Dev, 2016, 38: 461- 470. doi: 10.1016/j.braindev.2015.10.013
30	London K , Howman-Giles R . Normal cerebral FDG uptake during childhood. Eur J Nucl Med Mol Imaging, 2014, 41: 723- 735. doi: 10.1007/s00259-013-2639-9
31	Antonio M , Cerne D , Sara B , Sara B , Enrico M , Pietro B , Stefano M , Chiara M , Silvia S , Mobilia EM , Cappa SF , Luana B , Diego F , Gastaldi M . Retrograde amnesia in LGI1 and CASPR2 limbic encephalitis: two case reports and a systematic literature review. Eur J Neurol, 2025, 32: e70113. doi: 10.1111/ene.70113
32	Baudin P , Cousyn L , Navarro V . The LGI1 protein: molecular structure, physiological functions and disruption-related seizures. Cell Mol Life Sci, 2021, 79: 16.
33	Hébert J , Riche B , Vogrig A , Muñiz-Castrillo S , Joubert B , Picard G , Rogemond V , Psimaras D , Alentorn A , Berzero G , Desestret V , Rabilloud M , Honnorat J . Epidemiology of paraneoplastic neurologic syndromes and autoimmune encephalitides in France. Neurol Neuroimmunol Neuroinflamm, 2020, 7: e883. doi: 10.1212/NXI.0000000000000883
34	Irani SR , Michell AW , Lang B , Pettingill P , Waters P , Johnson MR , Schott JM , Armstrong RJ , S Zagami A , Bleasel A , Somerville ER , Smith SM , Vincent A . Faciobrachial dystonic seizures precede LGI1 antibody limbic encephalitis. Ann Neurol, 2011, 69: 892- 900. doi: 10.1002/ana.22307
35	Li TR , Zhang YD , Wang Q , Shao XQ , Lv RJ . Recognition of seizure semiology and semiquantitative FDG-PET analysis of anti-LGI1 encephalitis. CNS Neurosci Ther, 2021, 27: 1173- 1181. doi: 10.1111/cns.13707
36	Joubert B . The neurobiology and immunology of CASPR2-associated neurological disorders. Rev Neurol (Paris), 2024, 180: 950- 956. doi: 10.1016/j.neurol.2024.09.005
37	Cornacchini S , Farina A , Contento M , Berti V , Biggi M , Barilaro A , Massacesi L , Damato V , Rosati E . Long-term-video monitoring EEG and 18F-FDG-PET are useful tools to detect residual disease activity in anti-LGI1-Abs encephalitis: a case report. Front Neurol, 2022, 13: 949240. doi: 10.3389/fneur.2022.949240
38	Liang M , Niu N , Jia C , Fan S , Liu L , Cui R , Guan H . Diagnostic superiority of 18 F-FDG PET over MRI in detecting anti-LGI1 autoimmune encephalitis: a comparative study with insights into faciobrachial dystonic seizures mechanisms and recurrence identification. Clin Nucl Med, 2023, 48: e516- e522. doi: 10.1097/RLU.0000000000004862
39	Navarro V , Kas A , Apartis E , Chami L , Rogemond V , Levy P , Psimaras D , Habert MO , Baulac M , Delattre JY , Honnorat J , Collaborators . Motor cortex and hippocampus are the two main cortical targets in LGI1-antibody encephalitis. Brain, 2016, 139 (Pt 4): 1079- 1093.
40	Zhao Y , Yuan Y , Wang RZ , Cui M , Chen SF , Chen KL , Li MM , Huang YY , Zhang HN , Zhang Y , Zhao M , Tian H , Sun L , Yu JT . Clinical, electroencephalogram and imaging characteristics of patients with anti-LGI1 antibody encephalitis: a multicenter cohort study. CNS Neurosci Ther, 2025, 31: e70414. doi: 10.1111/cns.70414
41	Sánchez-Ordúz L , Gállego Pérez-Larraya J , Grisanti F , Centeno M , Arbizu J . CASPR2 antibody-associated limbic encephalitis: contribution of visual aided analysis of ¹⁸F-FDG PET images using normal database comparison. Rev Esp Med Nucl Imagen Mol (Engl Ed), 2020, 39: 92- 95.
42	Marongiu A , Galleri P , Mura A , Solla P , Madeddu G , Spanu A , Nuvoli S . ¹⁸F-FDG brain PET/CT metabolic imaging in patients with suspected autoimmune encephalitis (AE) in the early stage: can the procedure play a complementary diagnostic role. ?Brain Sci, 2025, 15: 113. doi: 10.3390/brainsci15020113
43	Seniaray N , Verma R , Ranjan R , Belho E , Mahajan H . Metabolic imaging patterns on 18F-FDG PET in acute and subacute LGI1 autoimmune limbic encephalitis. Clin Nucl Med, 2021, 46: e27- e28. doi: 10.1097/RLU.0000000000003258
44	Sadaghiani MS , Roman S , Diaz-Arias LA , Habis R , Venkatesan A , Probasco JC , Solnes LB . Comparison of quantitative FDG-PET and MRI in anti-LGI1 autoimmune encephalitis. Neuroradiology, 2023, 65: 1225- 1238. doi: 10.1007/s00234-023-03165-2
45	Liu X , Shan W , Zhao X , Ren J , Ren G , Chen C , Shi W , Lv R , Li Z , Liu Y , Ai L , Wang Q . The clinical value of ¹⁸F-FDG-PET in autoimmune encephalitis associated with LGI1 antibody. Front Neurol, 2020, 11: 418. doi: 10.3389/fneur.2020.00418
46	Budhram A , Sechi E , Flanagan EP , Dubey D , Zekeridou A , Shah SS , Gadoth A , Naddaf E , McKeon A , Pittock SJ , Zalewski NL . Clinical spectrum of high-titre GAD65 antibodies. J Neurol Neurosurg Psychiatry, 2021, 92: 645- 654. doi: 10.1136/jnnp-2020-325275
47	Zhang Z , Fan S , Ren H , Zhou L , Guan H . Clinical characteristics and prognosis of anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor encephalitis. BMC Neurol, 2021, 21: 490. doi: 10.1186/s12883-021-02520-1
48	Gagnon MM , Savard M . Limbic encephalitis associated with GAD65 antibodies: brief review of the relevant literature. Can J Neurol Sci, 2016, 43: 486- 493. doi: 10.1017/cjn.2016.13
49	Vacchiano V , Giannoccaro MP , Napolitano RP , Liguori R , Allegri V , Rinaldi R , Spinardi L . Combined brain positron emission tomography/magnetic resonance imaging in GABA_A receptor encephalitis. Eur J Neurol, 2019, 26: e88- e89.
50	Kojima G , Inaba M , Bruno MK . PET-positive extralimbic presentation of anti-glutamic acid decarboxylase antibody-associated encephalitis. Epileptic Disord, 2014, 16: 358- 361. doi: 10.1684/epd.2014.0666
51	Baizabal-Carvallo JF , Jankovic J . Stiff-person syndrome: insights into a complex autoimmune disorder. J Neurol Neurosurg Psychiatry, 2015, 86: 840- 848. doi: 10.1136/jnnp-2014-309201
52	Wang K , Zhao X , Yuan L , Chen Q , Wang Q , Ai L . Cortical metabolic characteristics of anti-leucine-rich glioma-inactivated 1 antibody encephalitis based on ¹⁸F-FDG PET. Front Neurol, 2023, 14: 1100760. doi: 10.3389/fneur.2023.1100760
53	Andersen JV . The glutamate/GABA-glutamine cycle: insights, updates, and advances. J Neurochem, 2025, 169: e70029. doi: 10.1111/jnc.70029
54	Sears SM , Hewett SJ . Influence of glutamate and GABA transport on brain excitatory/inhibitory balance. Exp Biol Med (Maywood), 2021, 246: 1069- 1083. doi: 10.1177/1535370221989263
55	Hashimoto K , Nakamura T , Fujita Y , Furuta M , Makioka K , Shimoda Y , Iizuka T , Ikeda Y . Coupling of cortical hyperintense signals and increased glucose metabolism in a case of anti-GABAA receptor antibody-associated encephalitis. Intern Med, 2023, 62: 3545- 3548. doi: 10.2169/internalmedicine.1535-22
56	Cezar M , Belletto R , Polidori S , Soive L , Campitiello M , Legros PO , Egea J , Plastino F , Benaiteau M , Tyvaert L , Tortora G , Longo R . Managing paraneoplastic GABA BR-related limbic encephalitis in a patient with a small cell lung cancer receiving an Immune-Checkpoint Inhibitor (ICI) therapy: description of a case report. BMC Neurol, 2025, 25: 467. doi: 10.1186/s12883-025-04483-z
57	Liu X , Yu T , Zhao X , Li G , Lv R , Ai L , Wang Q . ¹⁸F-fluorodeoxy-glucose positron emission tomography pattern and prognostic predictors in patients with anti-GABAB receptor encephalitis. CNS Neurosci Ther, 2022, 28: 269- 278. doi: 10.1111/cns.13767
58	Kim TJ , Lee ST , Shin JW , Moon J , Lim JA , Byun JI , Shin YW , Lee KJ , Jung KH , Kim YS , Park KI , Chu K , Lee SK . Clinical manifestations and outcomes of the treatment of patients with GABAB encephalitis. J Neuroimmunol, 2014, 270 (1/2): 45- 50.
59	Fan S , Jia C , Liang M , Ren H , Zhang T , Li Q , Huang Z , Yen TC , OuYang C , Cui R , Guan H . Patterns of Tau pathology in patients with anti-IgLON5 disease visualized by Florzolotau (18F) PET. J Neurol, 2025, 272: 115. doi: 10.1007/s00415-024-12874-4
60	Wang C , Kong F , Yu X , Li Y , Yang M , Si Z , Liu R , Hu K , Yang B . Clinical characteristics and outcome in patients with anti-AMPAR2 encephalitis: a case series and literature review. Front Hum Neurosci, 2025, 19: 1586005. doi: 10.3389/fnhum.2025.1586005
61	Milano C , Saylam E , Papi C , Marmolejo L , Sankovic A , Reinecke R , Kerstens J , Pizzanelli C , Simabukuro MM , Benaiteau M , Joubert B , Gastaldi M , Dutra LA , Leypoldt F , Jansen M , Kawachi I , Akiyama H , Boy N , Bozzetti S , Christensen PB , Businaro P , Dinoto A , Friedman-Korn T , Fujiwara U , Fukumoto T , Fuse K , Hooshmand SI , Hurst L , Iorio R , Korn-Lubetzki I , Rodrigues AFL , Mariotto S , Michael J , Morimoto Y , Neuteboom RF , Piquet AL , Rossetti AO , Rumpler-Kreiner S , Santoro JD , Schwendinger F , Shen B , Syrbe S , Troger J , Wagner I , Bien CG , Martinez-Hernandez E , Armangue T , Höftberger R , Iizuka T , Titulaer MJ , Honnorat J , Graus F , Dalmau JO , Magaña S , Spatola M . Clinical characterization and long-term outcome in children and adults with anti-AMPA receptor encephalitis. Neurol Neuroimmunol Neuroinflamm, 2025, 12: e200453. doi: 10.1212/NXI.0000000000200453
62	Cong H , Yuan L , Zheng P , Xu X , Dong W , Tian D , Yin L , Ma Y , Song T , Zhao Y , Xu Y , Zhang M , Liu B , Chang G , Sun K , Ma W , Ai L , Xu W . ¹⁸F-FDG PET/CT reveals characteristic prefrontal-posterior cingulate hypometabolism in anti-AMPAR encephalitis to understand cerebral function: insights from an eight-patient cohort. CNS Neurosci Ther, 2025, 31: e70633. doi: 10.1111/cns.70633
63	Grativvol RS , Cavalcante WCP , Castro LHM , Nitrini R , Simabukuro MM . Updates in the diagnosis and treatment of paraneoplastic neurologic syndromes. Curr Oncol Rep, 2018, 20: 92. doi: 10.1007/s11912-018-0721-y
64	Spatola M , Stojanova V , Prior JO , Dalmau J , Rossetti AO . Serial brain ¹⁸FDG-PET in anti-AMPA receptor limbic encephalitis. J Neuroimmunol, 2014, 271 (1/2): 53- 55.
65	Wang X , Zhao C , Chen Q , Yu W , Zhao S , Wang P , Sun L , Xu L , Xu Y . Anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor 2 encephalitis with olfactory hallucination: a case report and literature review. Front Immunol, 2025, 16: 1444053. doi: 10.3389/fimmu.2025.1444053
66	Jia Y , Li M , Wang H , Zhang M , Wang Y . The peculiar clinical symptoms and treatment of limbic encephalitis associated with AMPA receptor antibody. Eur Neurol, 2021, 84: 206- 211. doi: 10.1159/000515592
67	Gaig C , Sabater L . New knowledge on anti-IgLON5 disease. Curr Opin Neurol, 2024, 37: 316- 321. doi: 10.1097/WCO.0000000000001271
68	Graus F , Sabater L , Gaig C , Gelpi E , Iranzo A , Dalmau JO , Santamaria J . Anti-IgLON5 disease 10 years later: what we know and what we do not know. Neurol Neuroimmunol Neuroinflamm, 2025, 12: e200353. doi: 10.1212/NXI.0000000000200353
69	Hartung TJ , Bartels F , Kuchling J , Krohn S , Leidel J , Mantwill M , Wurdack K , Yogeshwar S , Scheel M , Finke C . MRI findings in autoimmune encephalitis. Rev Neurol (Paris), 2024, 180: 895- 907. doi: 10.1016/j.neurol.2024.08.006
70	Seniaray N , Verma R , Ranjan R , Belho E , Mahajan H . Lewy body dementia associated with anti-IgLON 5 encephalitis detected on ¹⁸F fluorodeoxyglucose positron emission tomography/computed tomography and 99mTc-TRODAT single-photon emission computed tomography/computed tomography. Indian J Nucl Med, 2022, 37: 94- 96. doi: 10.4103/ijnm.ijnm_108_21
71	Zhang W , Niu N , Cui R . Serial 18F-FDG PET/CT findings in a patient with IgLON5 encephalopathy. Clin Nucl Med, 2016, 41: 787- 788. doi: 10.1097/RLU.0000000000001339
72	Li EC , Zhang TY , Cai MT , Su SY , Shen CH , Lai QL , Zhang YX . Clinical and paraclinical characterizations, management, and prognosis in DPPX antibody-associated encephalitis: a systematic review. Neurol Neuroimmunol Neuroinflamm, 2025, 12: e200350. doi: 10.1212/NXI.0000000000200350
73	Tobin WO , Lennon VA , Komorowski L , Probst C , Clardy SL , Aksamit AJ , Appendino JP , Lucchinetti CF , Matsumoto JY , Pittock SJ , Sandroni P , Tippmann-Peikert M , Wirrell EC , McKeon A . DPPX potassium channel antibody: frequency, clinical accompaniments, and outcomes in 20 patients. Neurology, 2014, 83: 1797- 1803. doi: 10.1212/WNL.0000000000000991
74	Dominguez L , McKeon A , Tobin WO , Lopez-Chiriboga S . Long term outcomes in patients with anti-DPPX autoimmunity. J Neuroimmunol, 2023, 384: 578214. doi: 10.1016/j.jneuroim.2023.578214
75	Zhou Q , Zhu X , Meng H , Zhang M , Chen S . Anti-dipeptidyl-peptidase-like protein 6 encephalitis, a rare cause of reversible rapid progressive dementia and insomnia. J Neuroimmunol, 2020, 339: 577114. doi: 10.1016/j.jneuroim.2019.577114
76	Piepgras J , Höltje M , Michel K , Li Q , Otto C , Drenckhahn C , Probst C , Schemann M , Jarius S , Stöcker W , Balint B , Meinck HM , Buchert R , Dalmau J , Ahnert-Hilger G , Ruprecht K . Anti-DPPX encephalitis: pathogenic effects of antibodies on gut and brain neurons. Neurology, 2015, 85: 890- 897. doi: 10.1212/WNL.0000000000001907
77	Wan W , Pan Y , Chen Y , Bai S , Yao X , Lin Y , Wu J , Ni L , Mei Y , Qiu H , Zhou Y , Hao Y , Guan Y . The effect of double filtration plasmapheresis and corticosteroids on patients with anti-dipeptidyl-peptidase-like protein 6 encephalitis. Ther Apher Dial, 2024, 28: 141- 151. doi: 10.1111/1744-9987.14039
78	Guo K , Liu X , Gong X , Li A , Liu Y , Li X , Zhou D , Hong Z . Autoimmune encephalitis with mGluR5 antibodies: a case series from China and review of the literature. Front Immunol, 2023, 14: 1146536. doi: 10.3389/fimmu.2023.1146536
79	Deng M , Xiong J , Kong Z , Wang X , Li T . Case report. Clinical features and management of anti-mGluR1 encephalitis: case illustration and review of the literature. Front Integr Neurosci, 2025, 19: 1580767. doi: 10.3389/fnint.2025.1580767
80	Li YX , Wang RY , Hao YL . Clinical characteristics, treatment, and outcomes in anti-metabotropic glutamate receptor-1 encephalitis: a systematic review. Clin Neurol Neurosurg, 2025, 259: 109229. doi: 10.1016/j.clineuro.2025.109229
81	Khojah O , Makkawi S , Alghamdi S . Anti-mGluR1 encephalitis: case illustration and systematic review. Front Neurol, 2023, 14: 1142160. doi: 10.3389/fneur.2023.1142160
82	Sun Y , Tao JX , Han X , Wang X , Zhu Y , Lian Y , Ren G , Wang Q . Clinical features and brain MRI volumetric changes in anti-mGluR5 encephalitis. Ann Clin Transl Neurol, 2023, 10: 1407- 1416. doi: 10.1002/acn3.51831
83	Abd-Elrahman KS , Ferguson SSG . Noncanonical metabotropic glutamate receptor 5 signaling in Alzheimer's disease. Annu Rev Pharmacol Toxicol, 2022, 62: 235- 254. doi: 10.1146/annurev-pharmtox-021821-091747
84	Machado LS , Vidor P , Perquim L , Limberger C , Machado L , Rocha A , Soares C , Rahmouni N , S Brum W , Bellaver B , Ferreira PCL , Borelli WV , da Costa JC , Malpetti M , Pascoal TA , Souza DO , Edison P , Blennow K , Zetterberg H , Ashton NJ , Benedet AL , Serrano-Pozo A , Rosa-Neto P , Zimmer ER . Association between FDG-and TSPO-PET signals across human and animal studies investigating neurodegenerative conditions: a systematic review. Mol Psychiatry, 2026, 31: 559- 575. doi: 10.1038/s41380-025-03160-4
85	Wijesinghe SS , Rowe JB , Mason HD , Allinson KSJ , Thomas R , Vontobel DS , Fryer TD , Hong YT , Bacioglu M , Spillantini MG , van den Ameele J , O'Brien JT , Kaalund S , Malpetti M , Quaegebeur A . Post-mortem validation of in vivo TSPO PET as a microglial biomarker. Brain, 2025, 148: 1904- 1910. doi: 10.1093/brain/awaf078
86	Bodini B , Poirion E , Tonietto M , Benoit C , Palladino R , Maillart E , Portera E , Battaglini M , Bera G , Kuhnast B , Louapre C , Bottlaender M , Stankoff B . Individual mapping of innate immune cell activation is a candidate marker of patient-specific trajectories of worsening disability in multiple sclerosis. J Nucl Med, 2020, 61: 1043- 1049. doi: 10.2967/jnumed.119.231340
87	Herranz E , Treaba CA , Barletta VT , Mehndiratta A , Ouellette R , Sloane JA , Ionete C , Babu S , Mastantuono M , Magon S , Loggia ML , Makary MM , Hooker JM , Catana C , Kinkel RP , Nicholas R , Klawiter EC , Magliozzi R , Mainero C . Characterization of cortico-meningeal translocator protein expression in multiple sclerosis. Brain, 2024, 147: 2566- 2578. doi: 10.1093/brain/awae030
88	Barletta VT , Herranz E , Treaba CA , Mehndiratta A , Ouellette R , Granberg T , Klawiter EC , Ionete C , Sloane JA , Mainero C . In vivo characterization of microglia and myelin relation in multiple sclerosis by combined 11C-PBR28 PET and synthetic MRI. J Neurol, 2023, 270: 3091- 3102. doi: 10.1007/s00415-023-11621-5
89	Al-Abdulrasul H , Ajalin R , Tuisku J , Zetterberg H , Blennow K , Vahlberg T , Ekblad L , Helin S , Forsback S , Rinne JO , Brück A . Neuroinflammation in Parkinson's disease: a study with [¹¹ C]PBR28 PET and cerebrospinal fluid markers. Parkinsonism Relat Disord, 2025, 130: 107177. doi: 10.1016/j.parkreldis.2024.107177
90	Rodríguez-Chinchilla T , Quiroga-Varela A , Molinet-Dronda F , Belloso-Iguerategui A , Merino-Galan L , Jimenez-Urbieta H , Gago B , Rodriguez-Oroz MC . [¹⁸F]-DPA-714 PET as a specific in vivo marker of early microglial activation in a rat model of progressive dopaminergic degeneration. Eur J Nucl Med Mol Imaging, 2020, 47: 2602- 2612. doi: 10.1007/s00259-020-04772-4
91	Carter K , Cicero S , Rissanen E , Dubey S , Weiner HL , Singhal T . Assessment of microglial activation in Alzheimer disease using 18 F-PBR06 PET. Clin Nucl Med, 2023, 48: 643- 644. doi: 10.1097/RLU.0000000000004630
92	López-Picón FR , Keller T , Bocancea D , Helin JS , Krzyczmonik A , Helin S , Damont A , Dollé F , Rinne JO , Haaparanta-Solin M , Solin O . Direct comparison of [¹⁸F]F-DPA with [¹⁸F]DPA-714 and [11C]PBR28 for neuroinflammation imaging in the same Alzheimer's disease model mice and healthy controls. Mol Imaging Biol, 2022, 24: 157- 166. doi: 10.1007/s11307-021-01646-5
93	Wang J , Jin L , Zhang X , Yu H , Ge J , Deng B , Li M , Zuo C , Chen X . Activated microglia by ¹⁸F-DPA714 PET in a case of anti-LGI1 autoimmune encephalitis. J Neuroimmunol, 2022, 368: 577879. doi: 10.1016/j.jneuroim.2022.577879
94	Shen R , Shen D , Zhou Q , Zhang M , Chen S . Antibody-mediated autoimmune encephalitis evaluated by ¹⁸F-DPA714 PET/MRI. Brain Behav Immun Health, 2022, 26: 100535. doi: 10.1016/j.bbih.2022.100535
95	Wang J , Ge J , Jin L , Deng B , Tang W , Yu H , Zhang X , Liu X , Xue L , Zuo C , Chen X . Characterization of neuroinflammation pattern in anti-LGI1 encephalitis based on TSPO PET and symptom clustering analysis. Eur J Nucl Med Mol Imaging, 2023, 50: 2394- 2408. doi: 10.1007/s00259-023-06190-8
96	Wang J , Ge J , Deng B , Lin H , Yang W , Sheng T , Tang W , Yu H , Zhang X , Li Y , Liu X , Zuo C , Chen X . Microglial activation visualized by [¹⁸F]-DPA714 PET is a potential marker of severity and prognosis for anti-LGI1 encephalitis. Eur J Neurol, 2025, 32: e70107. doi: 10.1111/ene.70107
97	Gelpi E , Reinecke R , Gaig C , Iranzo A , Sabater L , Molina-Porcel L , Aldecoa I , Endmayr V , Högl B , Schmutzhard E , Poewe W , Pfausler B , Popovic M , Pretnar-Oblak J , Leypoldt F , Matschke J , Glatzel M , Erro EM , Jerico I , Caballero MC , Zelaya MV , Mariotto S , Heidbreder A , Kalev O , Weis S , Macher S , Berger-Sieczkowski E , Ferrari J , Reisinger C , Klupp N , Tienari P , Rautila O , Niemelä M , Yilmazer-Hanke D , Guasp M , Bloem B , Van Gaalen J , Kusters B , Titulaer M , Fransen NL , Santamaria J , Dawson T , Holton JL , Ling H , Revesz T , Myllykangas L , Budka H , Kovacs GG , Lewerenz J , Dalmau J , Graus F , Koneczny I , Höftberger R . Neuropathological spectrum of anti-IgLON5 disease and stages of brainstem tau pathology: updated neuropathological research criteria of the disease-related tauopathy. Acta Neuropathol, 2024, 148: 53. doi: 10.1007/s00401-024-02805-y
98	Campetella L , Smolik K , Farina A , Joubert B , Muñiz-Castrillo S , Desestret V , Honnorat J . Neurodegeneration and the immune system: lessons from autoimmune encephalitis. J Neurol, 2025, 272: 359. doi: 10.1007/s00415-025-13094-0
99	Theis H , Bischof GN , Brüggemann N , Dargvainiene J , Drzezga A , Grüter T , Lewerenz J , Leypoldt F , Neumaier B , Wandinger KP , Ayzenberg I , van Eimeren T . In vivo measurement of tau depositions in anti-IgLON5 disease using [¹⁸F]PI-2620 PET. Neurology, 2023, 101: e2325- e2330.
100	Farina A , Villagrán-García M , Abichou-Klich A , Benaiteau M , Bernard E , Bouhour F , Desestret V , Joubert B , Picard G , Pinto AL , Pons L , Smolik K , Thobois S , Trouillet-Assant S , Honnorat J . Serum neurofilament light chain correlates with clinical severity and predicts mortality in anti-IgLON5 disease. Neurol Neuroimmunol Neuroinflamm, 2025, 12: e200498. doi: 10.1212/NXI.0000000000200498
101	Day GS , Gordon BA , McCullough A , Bucelli RC , Perrin RJ , Benzinger TLS , Ances BM . Flortaucipir (tau) PET in LGI1 antibody encephalitis. Ann Clin Transl Neurol, 2021, 8: 491- 497. doi: 10.1002/acn3.51297
102	Lu J , Ge J , Yu H , Zhao G , Chen X . Colocalization of increased midbrain signals in neuroinflammation and tau PET imaging suggests the diagnosis of progressive supranuclear palsy. Clin Nucl Med, 2024, 49: 346- 347. doi: 10.1097/RLU.0000000000005062
103	Wongso H , Harada R , Furumoto S . Current progress and future directions in non-Alzheimer's disease tau PET tracers. ACS Chem Neurosci, 2025, 16: 111- 127. doi: 10.1021/acschemneuro.4c00319
104	Strobel J , Müller HP , Ludolph AC , Beer AJ , Sollmann N , Kassubek J . New perspectives in radiological and radiopharmaceutical hybrid Imaging in progressive supranuclear palsy: a systematic review. Cells, 2023, 12: 2776. doi: 10.3390/cells12242776
105	Sanchez JS , Becker JA , Jacobs HIL , Hanseeuw BJ , Jiang S , Schultz AP , Properzi MJ , Katz SR , Beiser A , Satizabal CL , O'Donnell A , DeCarli C , Killiany R , El Fakhri G , Normandin MD , Gómez-Isla T , Quiroz YT , Rentz DM , Sperling RA , Seshadri S , Augustinack J , Price JC , Johnson KA . The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography. Sci Transl Med, 2021, 13: eabc0655. doi: 10.1126/scitranslmed.abc0655
106	Harada R , Furumoto S , Kudo Y , Yanai K , Villemagne VL , Okamura N . Imaging of reactive astrogliosis by positron emission tomography. Front Neurosci, 2022, 16: 807435. doi: 10.3389/fnins.2022.807435
107	Bauer J , Bien CG . Neuropathology of autoimmune encephalitides. Handb Clin Neurol, 2016, 133: 107- 120.
108	Ballweg A , Klaus C , Vogler L , Katzdobler S , Wind K , Zatcepin A , Ziegler SI , Secgin B , Eckenweber F , Bohr B , Bernhardt A , Fietzek U , Rauchmann BS , Stoecklein S , Quach S , Beyer L , Scheifele M , Simmet M , Joseph E , Lindner S , Berg I , Koglin N , Mueller A , Stephens AW , Bartenstein P , Tonn JC , Albert NL , Kümpfel T , Kerschensteiner M , Perneczky R , Levin J , Paeger L , Herms J , Brendel M . [¹⁸F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data. J Neuroinflammation, 2023, 20: 68. doi: 10.1186/s12974-023-02749-2

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Application of PET imaging in the diagnosis and prognosis prediction of autoimmune encephalitis

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Application of PET imaging in the diagnosis and prognosis prediction of autoimmune encephalitis

PET显像在自身免疫性脑炎诊断与预后预测中的应用

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