Expert consensus on diagnosis and treatment of depression in Parkinson's disease with integrated traditional Chinese and Western medicine (2021 edition)

doi:10.3969/j.issn.1672-6731.2021.12.002

Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2021, Vol. 21 ›› Issue (12): 1027-1035. doi: 10.3969/j.issn.1672-6731.2021.12.002

• Standard and Guideline • Previous Articles Next Articles

Expert consensus on diagnosis and treatment of depression in Parkinson's disease with integrated traditional Chinese and Western medicine (2021 edition)

YANG Ning¹, LIU Wei-guo², NING Hou-xu¹, LIU Zhen-guo³, XU Li-gang², ZHANG Jian-bin⁴, Expert Consensus Writing Group on Diagnosis and Treatment of Depression in Parkinson's Disease with Integrated Traditional Chinese and Western Medicine

1 Department of Traditional Chinese Medicine, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210024, Jiangsu, China;
2 Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210024, Jiangsu, China;
3 Department of Neurology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China;
4 Department of Acupuncture, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210017, Jiangsu, China

Received:2021-11-18 Online:2021-12-25 Published:2021-12-27
Supported by:
This study was supported by National Key Research and Development Program Major Chronic Non-Communicable Disease Prevention and Control Research Key Special Project (No. 2016YFC1306600, 2017YFC1310302), Key Research and Development Program of Jiangsu Province in 2019 (No. BE201961), and Special Project of Traditional Chinese Medicine Technology Development Program of Jiangsu Province in 2020 (No. 2020ZX17).

帕金森病抑郁中西医结合诊断与治疗专家共识（2021年版）

杨宁¹, 刘卫国², 宁厚旭¹, 刘振国³, 许利刚², 张建斌⁴, 帕金森病抑郁中西医结合诊断与治疗专家共识写作组

1 210024 南京医科大学附属脑科医院中医科;
2 210024 南京医科大学附属脑科医院神经内科;
3 200092 上海交通大学医学院附属新华医院神经内科;
4 210017 南京中医药大学第二附属医院针灸科

通讯作者: 刘卫国,Email:liuweiguo1111@sina.com;刘振国,Email:liuzhenguo@xinhuamed.com.cn
基金资助:
国家重点研发计划重大慢性非传染性疾病防控研究重点专项项目（项目编号：2016YFC1306600）；国家重点研发计划重大慢性非传染性疾病防控研究重点专项项目（项目编号：2017YFC1310302）；江苏省2019年省重点研发计划项目（项目编号：BE201961）；江苏省2020年度中医药科技发展专项项目（项目编号：2020ZX17）

Abstract

Abstract: Depression is the most common non-motor symptom of Parkinson's disease. However, the pathogenesis of depression in Parkinson's disease (DPD) remains undetermined. In order to further standardize and improve clinical diagnosis and treatment of DPD, relevant domestic experts of traditional Chinese and Western medicine from Jiangsu, Anhui, Shandong, Guangdong and Tianjin, Beijing, Shanghai jointly developed "Expert consensus on diagnosis and treatment of depression in Parkinson's disease with integrated traditional Chinese and Western medicine (2021 edition)" after detailed discussions both online and offline. With integrated traditional Chinese and Western medicine, the consensus sorts out diagnosis, evaluation tools and treatment of Western medicine according to the diagnostic criteria of Parkinson's disease and depression, and traditional Chinese medicine diagnosis and treatment system based on syndrome differentiation of Parkinson's disease according to the traditional Chinese medicine diagnosis of tremor syndrome and depression syndrome. Different treatment methods are provided for the early and advanced stages of Parkinson's disease according to the treatment principles of integrated traditional Chinese and Western medicine. The expert consensus is superior in clinic and relatively safe, which can be used as a reference for clinicians.

Key words: Parkinson disease, Depression, TCM WM therapy, Expert consensus (not in MeSH)

摘要： 抑郁是帕金森病最常见的非运动症状，帕金森病抑郁发病机制尚未完全阐明。为规范疾病诊断体系并提高临床疗效，通过组织全国7个省、直辖市中医和西医领域相关专家进行多次讨论和修改，共同制定《帕金森病抑郁中西医结合诊断与治疗专家共识（2021年版）》（以下简称共识）。共识中西医并重，参考帕金森病、抑郁症等相关诊断标准制定帕金森病抑郁西医诊断、评估量表和西医治疗的专家共识；同时参考中医颤证、郁证等相关中医诊断标准制定帕金森病抑郁中医辨证诊断体系和辨证论治的专家共识，并针对疾病早期和进展期采取不同的中西医结合治疗方法，有确切的临床优势且安全性较高，可供临床医师参考应用。

关键词: 帕金森病, 抑郁, 中西医结合疗法, 专家共识（非MeSH词）

YANG Ning, LIU Wei-guo, NING Hou-xu, LIU Zhen-guo, XU Li-gang, ZHANG Jian-bin, Expert Consensus Writing Group on Diagnosis and Treatment of Depression in Parkinson's Disease with Integrated Traditional Chinese and Western Medicine. Expert consensus on diagnosis and treatment of depression in Parkinson's disease with integrated traditional Chinese and Western medicine (2021 edition)[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2021, 21(12): 1027-1035.

杨宁, 刘卫国, 宁厚旭, 刘振国, 许利刚, 张建斌, 帕金森病抑郁中西医结合诊断与治疗专家共识写作组. 帕金森病抑郁中西医结合诊断与治疗专家共识（2021年版）[J]. 中国现代神经疾病杂志, 2021, 21(12): 1027-1035.

/ / Recommend / Download Citations

URL: https://journal11.magtechjournal.com/cjcnn/EN/10.3969/j.issn.1672-6731.2021.12.002

https://journal11.magtechjournal.com/cjcnn/EN/Y2021/V21/I12/1027

References

[1] Farabaugh AH, Locascio JJ, Yap L, Weintraub D, McDonald WM, Agoston M, Alpert JE, Growdon J, Fava M. Pattern of depressive symptoms in Parkinson's disease[J].Psychosomatics, 2009, 50:448-454.
[2] Raskind MA. Diagnosis and treatment of depression comorbid with neurologic disorders[J]. Am J Med, 2008, 121(11 Suppl 2):28-37.
[3] Ravina B, Camicioli R, Como PG, Marsh L, Jankovic J, Weintraub D, Elm J. The impact of depressive symptoms in early Parkinson disease[J]. Neurology, 2007, 69:342-347.
[4] Aarsland D, Larsen JP, Karlsen K, Lim NG, Tandberg E. Mental symptoms in Parkinson's disease are important contributors to caregiver distress[J]. Int J Geriatric Psychiatry, 1999, 14:866-874.
[5] Vriend C, Pattij T, van der Werf YD, Voorn P, Booij J, Rutten S, Berendse HW, van den Heuvel OA. Depression and impulse control disorders in Parkinson's disease:two sides of the same coin[J]?Neurosci Biobehav Rev, 2014, 38:60-71.
[6] Tan SK, Hartung H, Sharp T, Temel Y. Serotonin-dependent depression in Parkinson's disease:a role for the subthalamic nucleus[J]?Neuropharmacology, 2011, 61:387-399.
[7] Even C, Weintraub D. Is depression in Parkinson's disease (PD) a specific entity[J]?J Affect Disord, 2012, 139:103-112.
[8] Wu Q, Wu JJ, Qiu WQ, Yan ZY, Chen JX, Liu YY, Xue Z. Study progress of TCM syndrome and neuroplasticity mechanism of Parkinson's disease with depression[J]. Shi Jie Ke Xue Ji Shu:Zhong Yi Yao Xian Dai Hua, 2018, 20:76-80.[吴芊,吴佳佳,邱文琪,严志祎,陈家旭,刘玥芸,薛哲.帕金森伴抑郁的中医证候及神经可塑性机制研究进展[J].世界科学技术--中医药现代化, 2018, 20:76-80.]
[9] Yang N, Guo WF, Liu WG, Wang HD, Ning HX. Discussion on pathogenesis essence of Parkinson's disease based on distribution regularity of TCM syndrome elements of 300 cases[J]. Nanjing Zhong Yi Yao Da Xue Xue Bao, 2016, 32:540-542.[杨宁,过伟峰,刘卫国,王海东,宁厚旭. 300例帕金森病患者病机证素分布规律探讨[J].南京中医药大学学报, 2016, 32:540-542.]
[10] American Psychiatric Association DSM-Task Force Arlington VA US. Diagnostic and statistical manual of mental disorders:DSM-5^TM(5th ed)[J]. Codas, 2013, 25:191.
[11] Seppi K, Weintraub D, Coelho M, Perez-Lloret S, Fox SH, Katzenschlager R, Hametner EM, Poewe W, Rascol O, Goetz CG, Sampaio C. The movement disorder society evidence-based medicine review update:treatments for the non-motor symptoms of Parkinson's disease[J]. Mov Disord, 2011, 26 Suppl 3:42-80.
[12] Seppi K, Ray Chaudhuri K, Coelho M, Fox SH, Katzenschlager R, Perez Lloret S, Weintraub D, Sampaio C; the collaborators of the Parkinson's Disease Update on Non-Motor Symptoms Study Group on behalf of the Movement Disorders Society Evidence-Based Medicine Committee. Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review[J]. Mov Disord, 2019, 34:180-198.
[13] Neuropsychology and Behavioral Neurology Group of Chinese Medical Association, Parkinson's Disease and Movement Disorder Section of Neurologist Branch of Chinese Medical Doctor Association. Diagnostic criteria and treatment guidelines for depression, anxiety and psychotic disorders of Parkinson's disease[J]. Zhonghua Shen Jing Ke Za Zhi, 2013, 46:56-60.[中华医学会神经病学分会神经心理学与行为神经病学组,中华医学会神经病学分会帕金森病及运动障碍学组.帕金森病抑郁、焦虑及精神病性障碍的诊断标准及治疗指南[J].中华神经科杂志, 2013, 46:56-60.]
[14] Parkinson's Disease and Movement Disorders Group of Neurology Branch of Chinese Medical Association, Parkinson's Disease and Movement Disorder Professional Committee of Neurologist Branch of Chinese Medical Doctor Association. Diagnostic criteria for Parkinson's disease in China (2016 edition)[J]. Zhonghua Shen Jing Ke Za Zhi, 2016, 49:268-271.[中华医学会神经病学分会帕金森病及运动障碍学组,中国医师协会神经内科医师分会帕金森病及运动障碍专业委员会.中国帕金森病的诊断标准(2016版)[J].中华神经科杂志, 2016, 49:268-271.]
[15] Parkinson's Disease and Movement Disorders Group of Neurology Branch of Chinese Medical Association, Parkinson's Disease and Movement Disorder Section of Neurologist Branch of Chinese Medical Doctor Association. Expert consensus on the management of non-motor symptoms of Parkinson's disease (2020)[J]. Zhonghua Yi Xue Za Zhi, 2020, 100:2084-2091.[中华医学会神经病学分会帕金森病及运动障碍学组,中国医师协会神经内科医师分会帕金森病及运动障碍学组.帕金森病非运动症状管理专家共识(2020)[J].中华医学杂志, 2020, 100:2084-2091.]
[16] Parkinson's Disease and Movement Disorders Group of Neurology Branch of Chinese Medical Association, Parkinson's Disease and Movement Disorder Section of Neurologist Branch of Chinese Medical Doctor Association. Chinese guidelines for the treatment of Parkinson's disease (4th edition)[J]. Zhonghua Shen Jing Ke Za Zhi, 2020, 53:973-986.[中华医学会神经病学分会帕金森病及运动障碍学组,中国医师协会神经内科医师分会帕金森病及运动障碍学组.中国帕金森病治疗指南(第四版)[J].中华神经科杂志, 2020, 53:973-986.]
[17] Geriatrics Society of China Association of Traditional Chinese Medicine. Diagnostic and curative effect evaluation criteria of senile fibrillation syndrome in traditional Chinese medicine (trial)[J]. Beijing Zhong Yi Xue Yuan Xue Bao, 1992, 15:39-41.[中华全国中医学会老年医学会.中医老年颤证诊断和疗效评定标准(试行)[J].北京中医学院学报, 1992, 15:39-41.]
[18] Encephalopathy Professional Committee of Chinese Association of Chinese Medicine, National Depression Cooperation Group of Key Specialties of Encephalopathy under the National Administration of Traditional Chinese Medicine. Diagnostic criteria and treatment of traditional Chinese medicine syndromes of depression[J]. Beijing Zhong Yi Yao Da Xue Xue Bao, 2011, 34:810-811.[中华中医药学会脑病专业委员会,国家中医药管理局全国脑病重点专科抑郁症协作组.抑郁症中医证候诊断标准及治疗方案[J].北京中医药大学学报, 2011, 34:810-811.]
[19] Zhou ZY. Internal medicine of traditional Chinese medicine[M]. 2nd ed. Beijing:China Press of Traditional Chinese Medicine, 2017:373-380.[周仲瑛.中医内科学[M]. 2版.北京:中国中医药出版社, 2017:373-380.]
[20] Wu CH, Zhou XX, Xie M, Lin JS, Gao LL. Expert consensus for traditional Chinese medicine preventive treatment of diseases:Parkinson depression and/or anxiety[J]. Zhongguo Zhong Yi Yao Xin Xi Za Zhi, 2020, 27:1-5.[吴成翰,周小炫,谢敏,林菊珊,高丽丽.中医治未病·帕金森抑郁和/或焦虑专家共识[J].中国中医药信息杂志, 2020, 27:1-5.]
[21] Professional Committee on Neurology of Chinese Association of Integrative Medicine. Expert consensus on integrated traditional Chinese and western medicine diagnosis and treatment of depression[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2020, 40:141-148.[中国中西医结合学会神经科专业委员会.抑郁症中西医结合诊疗专家共识[J].中国中西医结合杂志, 2020, 40:141-148.]
[22] Richard IH, McDermott MP, Kurlan R, Lyness JM, Como PG, Pearson N, Factor SA, Juncos J, Serrano Ramos C, Brodsky M, Manning C, Marsh L, Shulman L, Fernandez HH, Black KJ, Panisset M, Christine CW, Jiang W, Singer C, Horn S, Pfeiffer R, Rottenberg D, Slevin J, Elme L, Press D, Hyson HC, McDonald W. A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease[J]. Neurology, 2012, 78:1229-1236.
[23] Dobkin RD, Menza M, Allen LA, Gara MA, Mark MH, Tiu J, Bienfait KL, Friedman J. Cognitive-behavioral therapy for depression in Parkinson's disease:a randomized, controlled trial[J]. Am J Psychiatry, 2011, 168:1066-1074.
[24] Brys M, Fox MD, Agarwal S, Biagioni M, Dacpano G, Kumar P, Pirraglia E, Chen R, Wu A, Fernandez H, Wagle Shukla A, Lou JS, Gray Z, Simon DK, Di Rocco A, Pascual-Leone A. Multifocal repetitive TMS for motor and mood symptoms of Parkinson disease:a randomized trial[J]. Neurology, 2016, 87:1907-1915.
[25] Makkos A, Pál E, Aschermann Z, Janszky J, Balázs É, Takács K, Karádi K, Komoly S, Kovács N. High-frequency repetitive transcranial magnetic stimulation can improve depression in Parkinson's disease:a randomized, double-blind, placebo-controlled study[J]. Neuropsychobiology, 2016, 73:169-177.
[26] Zhao H, Li WW, Gao JP, Zhou ZY, Lü L, Wang T, Gu XX, Fan Y, Lu ZY, Tang YP. Clinical trial on treatment of Parkinson's disease of gan-shen yin deficiency type by recipe for nourishing gan-shen[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2007, 27:780-784.[赵虹,李文伟,高俊鹏,周子懿,吕磊,汪涛,顾喜喜,范越,陆振宇,唐宇平.补肾养肝方药治疗肝肾阴虚型帕金森病临床研究[J].中国中西医结合杂志, 2007, 27:780-784.]
[27] Zhou Y, Wang DG, Lu ZY, Wang T, Zhao H. Treatment of 30 cases of Parkinson disease with yin deficiency of liver and kidney with bushen yanggan xifeng decoction[J]. Liaoning Zhong Yi Za Zhi, 2013, 40:929-931.[周洋,王德刚,陆征宇,汪涛,赵虹.补肾养肝熄风法治疗肝肾阴虚型帕金森病30例[J].辽宁中医杂志, 2013, 40:929-931.]
[28] Wu Y. Clinical efficacy of the bushen yanggan xifeng prescription on Parkinson's disease of the ganshen yinxu type[J]. Zhong Yi Lin Chuang Yan Jiu, 2016, 8:13-15.[武燕.补肾养肝熄风方药治疗肝肾阴虚型帕金森病疗效观察[J].中医临床研究, 2016, 8:13-15.]
[29] Tan ZH, Shen B, Zhang L, Chen XM, Song AQ. Clinical observation on the treatment of Chinese medicine of replenishing the liver and kidney combined with piribedil in treatment of advanced Parkinson's disease[J]. Hubei Zhong Yi Za Zhi, 2011, 33:20-21.[谭子虎,沈博,张丽,陈小敏,宋爱琴.补益肝肾中药联合吡贝地尔治疗晚期帕金森病的临床研究[J].湖北中医杂志, 2011, 33:20-21.]
[30] Yang LY. Clinical research on the effectiveness of dingchan-anshen decoction cure for sleep disorders in Parkinson's disease with the syndrome of liver-kidney yin deficiency[D].Nanjing:Nanjing University of Chinese Medicine, 2016.[杨立悦.定颤安神方治疗肝肾阴虚型帕金森病睡眠障碍临床疗效观察[D].南京:南京中医药大学, 2016.]
[31] Zhao JG, Gu XZ. Therapeutic effect of dingchan decoction on non-motor symptoms of Parkinson's disease with liver and kidney yin deficienc[J]. Zhejiang Zhong Xi Yi Jie He Za Zhi, 2011, 21:562-564.[赵建高,顾锡镇.定颤汤治疗肝肾阴虚型帕金森病非运动症状疗效观察[J].浙江中西医结合杂志, 2011, 21:562-564.]
[32] Zhang JP, Yan YM. Therapeutic effect of dingfeng-chuchan decoction combined with western medicine on 42 cases of liver and kidney deficiency fibrillation syndrome[J]. Jilin Zhong Yi Yao, 2012, 32:683-684.[张金培,闫咏梅.定风除颤汤联合西药治疗肝肾不足型颤证42例疗效观察[J].吉林中医药, 2012, 32:683-684.]
[33] Jiang HP, Fang MQ. Effect and mechanism of dingzhen decoction combined with dopazide tablets in the treatment of Parkinson's disease with liver and kidney yin deficiency[J].Sichuan Zhong Yi, 2019, 37:125-128.[蒋海平,方蔓倩.定振汤联合多巴丝肼片治疗肝肾阴虚型帕金森病的疗效及机制初探[J].四川中医, 2019, 37:125-128.]
[34] Lin SH. Analyzing the safety and efficacy of turtle deer dihuang decoction in the treatment of Parkinson's disease[J]. Zhongguo Chu Fang Yao, 2014, 12:10-11.[林善华.龟鹿地黄汤治疗肝肾阴虚型帕金森病的安全性和有效性探讨[J].中国处方药, 2014, 12:10-11.]
[35] Zhao GH, Sun F, Feng XG, Gao M. Treatment of non-motor symptoms of Parkinson's disease patients of gan-shen deficiency syndrome by guiling-pa'an granule:a multi-center double-blinded randomized controlled trial[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2013, 33:476-479.[赵国华,孙菲,冯学功,高敏.龟羚帕安颗粒治疗帕金森病肝肾不足证非运动症状的多中心随机双盲对照研究[J].中国中西医结合杂志, 2013, 33:476-479.]
[36] Lu YQ. Liang Jianfen's experience in treating Parkinson's disease from the yin deficiency of liver and kidney[J]. Shanxi Zhong Yi, 2011, 27:9.[卢要强.梁健芬从肝肾阴虚论治帕金森病经验简介[J].山西中医, 2011, 27:9.]
[37] Chen LJ. Evaluation of liuwei-dihuang pills in treating Parkinson's disease with liver and kidney yin deficiency[J].Zhong Wai Yi Liao, 2019, 38:176-178.[陈丽吉.六味地黄丸加减中药膏方治疗肝肾阴虚型帕金森病效果评价[J].中外医疗, 2019, 38:176-178.]
[38] Zhen CY, Luo XD. Luo Xiaodong's academic thought and experience in the treatment of Parkinson's disease[J]. Zhongguo Min Jian Liao Fa, 2018, 26:6-10.[郑春叶,雒晓东.雒晓东辨治帕金森病学术思想与经验探析[J].中国民间疗法, 2018, 26:6-10.]
[39] Dong W, Yang WM. Clinical trial on treatmrnt of Parkinson's disease with yin deficiency of liver and kidney by paning[J].Zhong Yi Yao Lin Chuang Za Zhi, 2015, 27:1417-1420.[董薇,杨文明.帕宁治疗肝肾阴虚型帕金森病的临床研究[J].中医药临床杂志, 2015, 27:1417-1420.]
[40] Shen XM, Zuo JL, Ma YZ, Lin HD, Qiao LJ, Niu YG, Jian YP, Zhu SR, Liu ZW, Yang ZF, Zhu XB, Xu YM, Wang Z. Peiyuan-dingchan decoction combined with medoba in the treatment of 42 cases of Parkinson's disease with liver and kidney yin deficiency[J]. Zhong Yi Yan Jiu, 2013, 26:12-14.[沈晓明,左俊岭,马云枝,林怀德,乔利军,牛昱光,菅艳萍,朱世瑞,刘政伟,杨泽锋,朱筱彬,许玉珉,王珍.培元定颤汤联合美多芭治疗肝肾阴虚型帕金森病42例[J].中医研究, 2013, 26:12-14.]
[41] Zhang F. Professor Peiyuan's experience in treating Parkinson's disease from the perspective of liver and kidney[D]. Shenyang:Liaoning University of Traditional Chinese Medicine, 2016.[张帆.裴媛教授从肝肾论治帕金森病经验总结[D].沈阳:辽宁中医药大学, 2016.]
[42] Zhang KF, Wang XX. Clinical application of pingchan-jieyu decoction in Parkinson's disease with depression of liver and kidney yin deficiency type[J]. Lin Chuang Yi Yao Wen Xian Dian Zi Za Zhi, 2017, 4:12018-12019.[张克飞,王旋旋.平颤解郁汤对肝肾阴虚型帕金森病伴抑郁障碍患者的临床应用分析[J].临床医药文献电子杂志, 2017, 4:12018-12019.]
[43] Wu YH, Liu C, Zhang XJ. Effects of pingchan-roujin granule on oxidative stress and inflammatory factors in patients with Parkinson's disease with liver and kidney yin deficiency[J].Shandong Yi Yao, 2016, 56:55-56.[吴远华,刘成,张祥军.平颤柔筋颗粒对肝肾阴虚型帕金森病患者氧化应激及炎性因子水平的影响[J].山东医药, 2016, 56:55-56.]
[44] Zhou J, Ye Q, Yuan CX. Random control study of treating Parkinson's disease with shudi-pingchan decoction[J].Zhonghua Zhong Yi Yao Xue Kan, 2014, 32:1395-1397.[周洁,叶青,袁灿兴.熟地平颤汤治疗帕金森氏病的随机对照研究[J].中华中医药学刊, 2014, 32:1395-1397.]
[45] Ma YZ, Zheng TC, Yao JJ, Li SN. Clinical study on xifeng-dingchan pills in treating Parkinson's disease with liver and kidney yin deficiency[J]. Zhong Yi Xue Bao, 2013, 28:587-588.[马云枝,郑太昌,姚静静,李书纳.熄风定颤丸治疗帕金森病肝肾阴虚证临床研究[J].中医学报, 2013, 28:587-588.]
[46] Ping QN. The effect of yangyin-dingchan decoction on the treatment of non-motor symptoms of Parkinson's disease with liver and kidney yin deficiency[J]. Lin Chuang He Li Yong Yao Za Zhi, 2016, 9:47-48.[平启年.养阴定颤汤治疗肝肾阴虚型帕金森病非运动症状的效果观察[J].临床合理用药杂志, 2016, 9:47-48.]
[47] Zhang WG. Clinical observation of yangyin-xifeng-tongluo decoction combined with madopar in the treatment of Parkinson's disease of liver and kidney yin deficiency[J].Shanghai Zhong Yi Yao Za Zhi, 2013, 47:36-37.[张卫国.养阴熄风通络汤联合美多巴治疗肝肾阴虚型帕金森病临床观察[J].上海中医药杂志, 2013, 47:36-37.]
[48] Song J, Liu J. Clinical observation on the treatment of hepatorenal deficiency Parkinson's disease with yishen-tiaogan-xiaochan decoction combined with dopazide tablets and praxol hydrochloride tablets[J]. Hebei Zhong Yi, 2018, 40:1516-1519.[宋娟,刘钧.益肾调肝消颤汤联合多巴丝肼片和盐酸普拉克索片治疗肝肾不足型帕金森病的疗效观察[J].河北中医, 2018, 40:1516-1519.]
[49] Li YM, Yu J, Zhao YP, Cong WH. Professor Yu Zhenxuan's experience in treating tremor from the liver and kidney[J]. Guang Ming Zhong Yi, 2019, 34:2934-2936.[李艳梅,于江,赵迎盼,丛伟红.于振宣教授从肝肾论治震颤经验[J].光明中医, 2019, 34:2934-2936.]
[50] Wu CH, Wu SY, Wang JM, Lin JS, Yang ZB, Fan DD, Xie BN, Lin QC. Zhenchan decoction with madopar for vibration syndrome of gan-shen deficiency syndrome[J]. Zhong Xi Yi Jie He Xin Nao Xue Guan Bing Za Zhi, 2008, 6:397-399.[吴成翰,吴松鹰,王谨敏,林菊珊,杨宗保,范德东,谢步霓,林求诚.镇颤汤治疗肝肾不足型颤证的临床研究[J].中西医结合心脑血管病杂志, 2008, 6:397-399.]
[51] Song L, Gong SG, Guo JF. The clinical value of zhichan decoction combined with dopaserizide tablets in the treatment of non-motor symptoms of Parkinson's disease with liver and kidney yin deficiency[J]. Dang Dai Yi Xue, 2017, 23:87-88.[宋亮,巩守刚,郭建芳.止颤汤联合多巴丝肼片治疗肝肾阴虚型帕金森病非运动症状的临床价值研究[J].当代医学, 2017, 23:87-88.]
[52] Niu CF. Clinical observation on the treatment of Parkinson's disease with liver and kidney deficiency[J]. Shi Yong Zhong Yi Yao Za Zhi, 2019, 35:1483-1484.[牛春甫.中西药合用治疗帕金森病肝肾不足型临床观察[J].实用中医药杂志, 2019, 35:1483-1484.]
[53] Huang ZL, Zhao Y, Lu Y, Liang Y, Tang LL. Clinical observation on 30 cases of Parkinson's disease of liver and kidney yin deficiency treated by integrated traditional Chinese and Western medicine[J]. Jiangsu Zhong Yi Yao, 2015, 47:20-22.[黄志兰,赵杨,陆艳,梁艳,唐莉莉.中西医结合治疗肝肾阴虚型帕金森病30例临床观察[J].江苏中医药, 2015, 47:20-22.]
[54] Cui XY, Li WT. Clinical study on 38 cases of non-motor symptoms of Parkinson's disease of liver and kidney yin deficiency with integrated traditional Chinese and Western medicine[J]. Jiangsu Zhong Yi Yao, 2015, 47:30-31.[崔笑玉,李文涛.中西医结合治疗肝肾阴虚型帕金森病非运动症状38例临床研究[J].江苏中医药, 2015, 47:30-31.]
[55] Wu ZH, Zhang XX. Clinical observation on 31 cases of Parkinson's disease with liver and kidney yin deficiency type treated by integrated traditional Chinese and Western medicine[J]. Beijing Zhong Yi Yao, 2013, 32:113-115.[吴之煌,张晓霞.中西医结合治疗帕金森病肝肾阴虚型31例临床观察[J].北京中医药, 2013, 32:113-115.]
[56] Bai QL, Feng Z. Effect of nourishing liver-kidney and extinguishing wind on the symptoms of Parkinson's disease of liver-kidney yin deficiency[J]. Liaoning Zhong Yi Za Zhi, 2010, 37:846-848.[白清林,封臻.滋补肝肾熄风定颤法对肝肾不足型帕金森病中医证候的影响[J].辽宁中医杂志, 2010, 37:846-848.]
[57] Di J, Wang FF, Cui CX, Liu Z, Zhong CB. Clinical observation of nourishing liver and kidney, yangxue-roujin to treat Parkinson's disease of liver and kidney yin deficiency[J].Zhong Yi Lin Chuang Yan Jiu, 2016, 8:3-6.[邸杰,王芬芬,崔春霞,刘钟,仲崇邦.滋补肝肾、养血柔筋法治疗肝肾阴虚型帕金森病的临床观察[J].中医临床研究, 2016, 8:3-6.]
[58] Zhu LM. Treatment of 42 cases of Parkinson's disease with liver and kidney yin deficiency by nourishing liver and kidney[J]. Zhong Yi Za Zhi, 2011, 52:143-144.[朱黎明.滋补肝肾法治疗肝肾阴虚型帕金森病42例[J].中医杂志, 2011, 52:143-144.]
[59] Ge J, He JC, Yuan CX. Clinical observation on treatment of Parkinson's disease by nourishing liver and kidney[J]. Shi Zhen Guo Yi Guo Yao, 2012, 23:3070-3072.[葛晶,何建成,袁灿兴.滋补肝肾法治疗帕金森病的临床疗效观察及机理探讨[J].时珍国医国药, 2012, 23:3070-3072.]
[60] Li ZT, Yang WB. Clinical observation of nourishing liver and kidney and tianjing yisui in the treatment of Parkinson's disease[J]. Shi Zhen Guo Yi Guo Yao, 2006, 17:258-259.[李种泰,杨文波.滋补肝肾填精益髓法治疗帕金森病临床观察[J].时珍国医国药, 2006, 17:258-259.]
[61] Zhou S. Recent clinical observation of acupuncture improving quality of life in patients with Parkinson's disease[D]. Beijing:Beijing University of Chinese Medicine, 2013.[周莎.针刺改善帕金森病患者生活质量的近期临床观察[D].北京:北京中医药大学, 2013.]
[62] Yuan Y. Clinical efficacy evaluation of "seven skull base points" in treating Parkinson's disease[D]. Beijing:China Academy of Chinese Medical Sciences, 2013.[袁盈."颅底七穴"治疗帕金森病的临床疗效评价研究[D].北京:中国中医科学院, 2013.]
[63] Dong J. Clinical experience of Qin's eight scalp needles for treatment of Parkinson's disease[J]. Zhongguo Zhen Jiu, 2014, 34:491-494.[董珺.秦氏"头八针"为主针刺治疗帕金森病[J].中国针灸, 2014, 34:491-494.]
[64] Zhang YP, Liu GM, Li YM. Effect of acupuncture combined with pramexole hydrochloride on Parkinson's disease with depression[J]. Beijing Zhong Yi Yao, 2020, 39:594-597.[张燕平,刘钢敏,李燕梅.针刺配合盐酸普拉克索对帕金森病伴抑郁疗效观察[J].北京中医药, 2020, 39:594-597.]
[65] Shen JE, Han F, Yang LY. Study on combined drug therapy for Parkinson's disease patients with depression[J]. Lin Chuang Yi Yao Wen Xian Dian Zi Za Zhi, 2019, 6:72.[沈金娥,韩菲,杨联勇.帕金森病伴抑郁患者的联合用药治疗方案研究[J].临床医药文献电子杂志, 2019, 6:72.]
[66] Yang M, Yang DD, Xiao W. A Meta-analysis of the integrated traditional Chinese medicine and western medicine for treatment of depression[J]. Zhongguo Quan Ke Yi Xue, 2013, 16:2006-2009.[杨敏,杨东东,肖文.中西医结合治疗抑郁症的Meta评价[J].中国全科医学, 2013, 16:2006-2009.]
[67] Zhu JF, Jin WD. Adverse reactions to antidepressants[J]. Yi Yao Dao Bao, 2018, 37:1198-1202.[朱建峰,金卫东.抗抑郁药物的不良反应[J].医药导报, 2018, 37:1198-1202.]
[68] Ma XH, Zhou LH. Clinical observation on the treatment of Parkinson's disease complicated with depression and sleep disorder with dingchan-anshen prescription[J]. Zhongguo Lao Nian Bao Jian Yi Xue, 2020, 18:71-72.[马晓花,周隆辉.定颤安神方治疗帕金森病合并抑郁伴睡眠障碍的临床观察[J].中国老年保健医学, 2020, 18:71-72.]
[69] Huang SD, Liang JF, Zhang XB, Yang XC, Zhou HM. Observation on curative effect of wuhu-zhuifeng powder in treating Parkinson's disease with depression of xueyu-fengdong type[J]. Guangzhou Zhong Yi Yao Da Xue Xue Bao, 2019, 36:611-615.[黄少东,梁健芬,张兴博,杨显超,周华梅.加味五虎追风散治疗血瘀风动型帕金森病合并抑郁状态的疗效观察[J].广州中医药大学学报, 2019, 36:611-615.]
[70] Wang L, Cai YL, Wang YX, Han H, Hou ZF, Xu ZJ, Xu L, Ma SL, Xu MA, Zhu H. Clinical research on jieyu yihao decoction combined with paroxetine hydrochloride in the treatment of Parkinson's disease combine with depressive symptoms[J].Zhong Yi Yao Lin Chuang Za Zhi, 2017, 29:1702-1705.[王莉,蔡永亮,王艳昕,韩辉,侯志峰,许珍晶,徐磊,马守亮,徐明安,朱红.解郁一号方联合盐酸帕罗西汀治疗帕金森病合并抑郁症状疗效观察[J].中医药临床杂志, 2017, 29:1702-1705.]
[71] Wei TH, Yang WM, Wang MX. The clinical efficacy and the effect on the contents of serum BDNF, 5-HT and NE of kangzhen-zhijing capsule in treating Parkinson's disease with depression of xueyu-fengdong type[J]. Zhong Yi Yao Lin Chuang Za Zhi, 2013, 25:1012-1016.[魏涛华,杨文明,汪美霞.抗震止痉胶囊对血瘀风动型帕金森病合并抑郁障碍临床疗效及血清BDNF、5-HT、NE含量的影响[J].中医药临床杂志, 2013, 25:1012-1016.]
[72] Liu H, Wang YF, Cui YY. Clinical research on shugan-jieyu capsule in treating Parkinson's disease complicated with depression[J]. Shi Jie Lin Chuang Yao Wu, 2015, 36:480-483.[刘红,王玉芬,崔艳艳.舒肝解郁胶囊治疗帕金森病合并抑郁的临床观察[J].世界临床药物, 2015, 36:480-483.]
[73] Ye XB. Efficacy of wuling capsule combined with sertraline in the treatment of Parkinson's disease complicated with depression[J]. Zhejiang Shi Yong Yi Xue, 2015, 20:199-200.[叶小斌.乌灵胶囊联合舍曲林治疗帕金森病合并抑郁状态的疗效观察[J].浙江实用医学, 2015, 20:199-200.]
[74] Qian ZL, Li WT. Clinical effect of zhichan decoction combined with chaihu-longgu-muli decoction in treating Parkinson's disease complicated with depression[J]. Zhongguo Lao Nian Xue Za Zhi, 2016, 36:5683-5685.[钱卓磊,李文涛.止颤汤合柴胡加龙骨牡蛎汤化裁治疗帕金森病合并抑郁的临床疗效[J].中国老年学杂志, 2016, 36:5683-5685.]
[75] Neurology Society of Chinese Association of Integrative Medicine. Chinese guidelines for diagnosis and treatment of cerebral infarction with integrated traditional Chinese and western medicine (2017)[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2018, 38:136-144.[中国中西医结合学会神经科专业委员会.中国脑梗死中西医结合诊治指南(2017)[J].中国中西医结合杂志, 2018, 38:136-144.]
[76] Han HJ. The safety of traditional Chinese medicine and methods to prevent the adverse reactions caused by traditional Chinese medicine[J]. Shi Jie Zui Xin Yi Xue Xin Xi Wen Zhai (Lian Xu Xing Dian Zi Qi Kan), 2019, 19:176.[韩海静.中药的安全性及预防中药所致不良反应的方法[J].世界最新医学信息文摘(连续型电子期刊), 2019, 19:176.]

Please choose a citation manager

Content to export

Expert consensus on diagnosis and treatment of depression in Parkinson's disease with integrated traditional Chinese and Western medicine (2021 edition)

帕金森病抑郁中西医结合诊断与治疗专家共识（2021年版）

RichHTML

PDF

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Feng ZHANG, Fan-gang MENG. Research progress of subthalamic nucleus deep brain stimulation in treatment of autonomic nerve dysfunction in Parkinson's disease [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 510-515.
[2]	Bo-wen CHANG, Jia-ming MEI, Chi XIONG, Peng CHEN, Man-li JIANG, Chao-shi NIU. Functional connectivity analysis in the brain of subthalamic nucleus deep brain stimulation in the improvement of depression in Parkinson's disease [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 532-539.
[3]	Yi-feng CHENG, Shao-ya YIN, De-qiu CUI, Chun-juan WANG, Guang-rui ZHAO, Ke-ke FENG. Long-term follow-up study of variable frequency stimulation mode deep brain stimulation for axial symptoms in Parkinson's disease [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 547-554.
[4]	Ping HE, Xin XU, Zhi-pei LING. Early-onset Parkinson's disease long-term followed up after subthalamic nucleus deep brain stimulation: one case report [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 555-558.
[5]	Min TU, Shuang-feng YANG, Yu-ling TAN, Xiao-ming WANG. Correlation analysis of retinal characteristics and disease severity in Parkinson's disease [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 559-566.
[6]	Ruo-lin SHI, Xiu-jie GAO, Jia-ning CUI, Yan SHAO, Lu-shuang XIE, Yi LIU. Advance on association between 5-hydroxytryptamine and non-motor symptoms in Parkinson's disease [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(6): 497-501.
[7]	Yu-han JIANG, Meng-xi ZHOU, Wei CHEN. Application of vestibular evoked myogenic potentials in the diagnosis of Parkinson's disease [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(3): 127-130.
[8]	Ying XU, Ya-xing GUI. The influence of dysregulated lipid metabolism on the progression of Parkinson's disease and its clinical implications [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(3): 131-138.
[9]	Shi-yi YE, Ke-zhong ZHANG. Dysarthria in Parkinson's disease [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(3): 139-145.
[10]	Yi-qing BI, Feng-juan WU, Yu-gang ZHU, Yi-ming LIU. Pathogenesis and treatment of Parkinson's disease with camptocormia [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(3): 146-150.
[11]	Qing ZHAO, Shi-ying BU, Ling-jing JIN. Research progress on robot-assisted gait training to improve gait disorder in Parkinson's disease [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(3): 151-157.
[12]	Zai-chao LIU, Yue JIAO, Juan LI, Xian-wen CHEN. The role of surface electromyography in the assessment of myotonia in Parkinson's disease [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(3): 158-163.
[13]	Meng-xi GONG, Ying-ying SUN, Chuan-ying XU, Wei ZHANG, Jie ZU, Gui-yun CUI. Correlation analysis between serum 8-hydroxy deoxyguanosine and malondialdehyde levels and cognitive dysfunction in patients with Parkinson's disease [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(3): 164-170.
[14]	Li JI, Ning YANG, Wei-guo LIU, Cheng-lin NIU. Relationship between autonomic nervous function and cognitive function in elderly patients with Parkinson's disease [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(3): 171-176.
[15]	Chen LIU, Jing GAN, Yu ZHANG, Zhen-guo LIU. Early-onset Parkinson's disease caused by LRRK2 R1067Q and GBA R202Q variation: one case report [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(3): 177-181.

模态框（Modal）标题

Please choose a citation manager

Content to export

Expert consensus on diagnosis and treatment of depression in Parkinson's disease with integrated traditional Chinese and Western medicine (2021 edition)

帕金森病抑郁中西医结合诊断与治疗专家共识（2021年版）

RichHTML

PDF

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments