Application of vestibular evoked myogenic potentials in the diagnosis of Parkinson's disease

doi:10.3969/j.issn.1672-6731.2024.03.003

Abstract

Abstract:

Vestibular evoked myogenic potentials (VEMPs), a key electrophysiological technique, is extensively utilized for the clinical evaluation of vestibular function. Patients with Parkinson's disease (PD) often have vestibular dysfunction, with VEMPs abnormalities being the most common. Based on the brief introduction of VEMPs technique, this review summarizes the features of VEMPs abnormalities, its association with clinical phenotype and underlying pathophysiological basis in patients with PD, so as to provide guidance for clinical research and practical application.

Key words: Parkinson disease, Vestibular evoked myogenic potentials, Review

摘要：

前庭诱发肌源性电位（VEMPs）是一种临床评估前庭功能的常用电生理检测技术。帕金森病患者常伴前庭功能异常，以VEMPs参数异常最为常见。本文在介绍VEMPs技术的基础上，就帕金森病患者VEMPs参数异常特征、与临床表型的关联性、潜在的病理生理学基础进行综述，为进一步的临床研究及应用提供新的思路。

关键词: 帕金森病, 前庭诱发肌源性电位, 综述

Yu-han JIANG, Meng-xi ZHOU, Wei CHEN. Application of vestibular evoked myogenic potentials in the diagnosis of Parkinson's disease[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(3): 127-130.

姜雨菡, 周梦溪, 陈伟. 前庭诱发肌源性电位在帕金森病诊断中的应用[J]. 中国现代神经疾病杂志, 2024, 24(3): 127-130.

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URL: https://journal11.magtechjournal.com/cjcnn/EN/10.3969/j.issn.1672-6731.2024.03.003

https://journal11.magtechjournal.com/cjcnn/EN/Y2024/V24/I3/127

References 24

1	Haider A , Elghazawy NH , Dawoud A , Gebhard C , Wichmann T , Sippl W , Hoener M , Arenas E , Liang SH . Translational molecular imaging and drug development in Parkinson's disease. Mol Neurodegener, 2023, 18: 11. doi: 10.1186/s13024-023-00600-z
2	Seidel K , Mahlke J , Siswanto S , Krüger R , Heinsen H , Auburger G , Bouzrou M , Grinberg LT , Wicht H , Korf HW , den Dunnen W , Rüb U . The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies. Brain Pathol, 2015, 25: 121- 135. doi: 10.1111/bpa.12168
3	Berkiten G , Tutar B , Atar S , Kumral TL , Saltürk Z , Akan O , Sari H , Onaran Ö , Biltekin Tuna Ö , Uyar Y . Assessment of the clinical use of vestibular evoked myogenic potentials and the video head impulse test in the diagnosis of early-stage Parkinson's disease. Ann Otol Rhinol Laryngol, 2023, 132: 41- 49. doi: 10.1177/00034894211067838
4	Rosengren SM , Young AS , Taylor RL , Welgampola MS . Vestibular function testing in the 21st century: video head impulse test, vestibular evoked myogenic potential, video nystagmography. Which tests will provide answers?. Curr Opin Neurol, 2022, 35: 64- 74. doi: 10.1097/WCO.0000000000001023
5	Vertigo Rehabilitation Committee, Chinese Association of Rehabilitation Medicine , Vertigo Committee, China Medical Education Association . Expert consensus on techniques for clinical ocular vestibular evoked myogenic potential assessment. Zhonghua Er Ke Xue Za Zhi, 2022, 20: 4- 9. URL
	中国康复医学会眩晕康复专业委员会, 中国医药教育协会眩晕专业委员会. 眼性前庭诱发肌源性电位临床检测技术专家共识. 中华耳科学杂志, 2022, 20: 4- 9. URL
6	The Vertigo Rehabilitation Committee of Chinese Association of Rehabilitation Medicine , Vertigo Committee of China Medicine Education Association . Expert consensus on clinical measurement techniques of vestibular evoked myogenic potential. Zhonghua Er Ke Xue Za Zhi, 2019, 17: 988- 992. URL
	中国康复医学会眩晕康复专业委员会, 中国医药教育协会眩晕专业委员会. 前庭诱发肌源性电位临床检测技术专家共识. 中华耳科学杂志, 2019, 17: 988- 992. URL
7	Taylor RL , Welgampola MS , Nham B , Rosengren SM . Vestibular-evoked myogenic potential testing in vestibular localization and diagnosis. Semin Neurol, 2020, 40: 18- 32. doi: 10.1055/s-0039-3402068
8	Gabelić T , Krbot Skorić M , Adamec I , Barun B , Zadro I , Habek M . The vestibular evoked myogenic potentials (VEMP) score: a promising tool for evaluation of brainstem involvement in multiple sclerosis. Eur J Neurol, 2015, 22: 261- 269, e21. doi: 10.1111/ene.12557
9	Cui W , Duan Z , Feng J . Assessment of vestibular-evoked myogenic potentials in Parkinson's disease: a systematic review and Meta-analysis. Brain Sci, 2022, 12: 956. doi: 10.3390/brainsci12070956
10	Pollak L , Prohorov T , Kushnir M , Rabey M . Vestibulocervical reflexes in idiopathic Parkinson disease. Neurophysiol Clin, 2009, 39 (4/5): 235- 240.
11	Di Lazzaro G , Schirinzi T , Giambrone MP , Di Mauro R , Palmieri MG , Rocchi C , Tinazzi M , Mercuri NB , Di Girolamo S , Pisani A . Pisa syndrome in Parkinson's disease: evidence for bilateral vestibulospinal dysfunction. Parkinsons Dis, 2018, ID8673486.
12	Pötter-Nerger M , Govender S , Deuschl G , Volkmann J , Colebatch JG . Selective changes of ocular vestibular myogenic potentials in Parkinson's disease. Mov Disord, 2015, 30: 584- 589. doi: 10.1002/mds.26114
13	de Natale ER , Ginatempo F , Paulus KS , Manca A , Mercante B , Pes GM , Agnetti V , Tolu E , Deriu F . Paired neurophysiological and clinical study of the brainstem at different stages of Parkinson's disease. Clin Neurophysiol, 2015, 126: 1871- 1878. doi: 10.1016/j.clinph.2014.12.017
14	Klunk D , Woost TB , Fricke C , Classen J , Weise D . Differentiating neurodegenerative parkinsonian syndromes using vestibular evoked myogenic potentials and balance assessment. Clin Neurophysiol, 2021, 132: 2808- 2819. doi: 10.1016/j.clinph.2021.08.012
15	Gaur A , Rajamanickam R , Chinnathambi C , Selvaraju D , Sakthivadivel V . Association of cervical vestibular-evoked myogenic potentials (VEMP) and postural instability in patients with Parkinson's disease: a cross-sectional study. Ann Neurosci, 2022, 29 (2/3): 137- 143.
16	Park JH , Kim MS , Kang SY . Initial vestibular function may be associated with future postural instability in Parkinson's disease. J Clin Med, 2022, 11: 5608. doi: 10.3390/jcm11195608
17	Xie WY , Shen Y , Chen Y , Zhuang S , Wang YL , Jin H , Li HX , Yan JH , Li Y , Mao CJ , Dai YP , Liu CF . REM sleep without atonia and vestibular-evoked myogenic potentials: clinical brainstem dysfunction in early-stage Parkinson's disease and isolated REM sleep behavior disorder. Sleep Med, 2022, 89: 122- 129. doi: 10.1016/j.sleep.2021.12.004
18	de Natale ER , Ginatempo F , Paulus KS , Pes GM , Manca A , Tolu E , Agnetti V , Deriu F . Abnormalities of vestibular-evoked myogenic potentials in idiopathic Parkinson's disease are associated with clinical evidence of brainstem involvement. Neurol Sci, 2015, 36: 995- 1001. doi: 10.1007/s10072-014-2054-4
19	Park JH , Kang SY . Dizziness in Parkinson's disease patients is associated with vestibular function. Sci Rep, 2021, 11: 18976. doi: 10.1038/s41598-021-98540-5
20	Shalash AS , Hassan DM , Elrassas HH , Salama MM , Méndez-Hernández E , Salas-Pacheco JM , Arias-Carrión O . Auditory- and vestibular-evoked potentials correlate with motor and non-motor features of Parkinson's disease. Front Neurol, 2017, 8: 55.
21	Pötter-Nerger M , Reich MM , Colebatch JG , Deuschl G , Volkmann J . Differential effect of dopa and subthalamic stimulation on vestibular activity in Parkinson's disease. Mov Disord, 2012, 27: 1268- 1275. doi: 10.1002/mds.25061
22	Wellings TP , Brichta AM , Lim R . Altered neurofilament protein expression in the lateral vestibular nucleus in Parkinson's disease. Exp Brain Res, 2017, 235: 3695- 3708. doi: 10.1007/s00221-017-5092-3
23	Shen Y , Xie WY , Li HX , Wang F , Dai YP , Liu CF . Evaluation of brainstem function using vestibular evoked myogenic potentials in patients with early-stage Parkinson's disease. Zhonghua Shen Jing Ke Za Zhi, 2023, 56: 485- 493.
	沈赟, 谢伟晔, 李函星, 王芬, 戴永萍, 刘春风. 前庭诱发肌源性电位对早期帕金森病患者脑干功能的评估. 中华神经科杂志, 2023, 56: 485- 493.
24	Carpinelli S , Valko PO , Waldvogel D , Buffone E , Baumann CR , Straumann D , Werth E , Bockisch CJ , Weber KP , Valko Y . Distinct vestibular evoked myogenic potentials in patients with Parkinson disease and progressive supranuclear palsy. Front Neurol, 2021, 11: 598763. doi: 10.3389/fneur.2020.598763

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