The influence of dysregulated lipid metabolism on the progression of Parkinson's disease and its clinical implications

doi:10.3969/j.issn.1672-6731.2024.03.004

Abstract

Abstract:

Lipid metabolism may play a role in the onset and progression of Parkinson's disease (PD), involving various pathological mechanisms such as abnormal folding and accumulation of α-synuclein (α-Syn), ferroptosis, GBA1 gene mutation, and mitochondrial dysfunction, etc.. This article reviews the lipid metabolism abnormalities associated with Parkinson's disease and explores potential related pathophysiological mechanism, aiming to provide new insights into the early diagnosis and treatment of Parkinson's disease.

Key words: Parkinson disease, Lipid metabolism, alpha-Synuclein, Glucosylceramidase, Genes, Mutation, Review

摘要：

脂质代谢可能参与帕金森病的发生及进展，涉及α-突触核蛋白异常折叠及积聚、铁死亡、GBA1基因变异、线粒体功能障碍等多种病理生理学机制。本文综述帕金森病的脂质代谢异常以及可能的相关致病机制，为帕金森病的早期诊断与治疗探索新的思路。

关键词: 帕金森病, 脂类代谢, α突触核蛋白, 葡糖苷酰鞘氨醇酶, 基因, 突变, 综述

Ying XU, Ya-xing GUI. The influence of dysregulated lipid metabolism on the progression of Parkinson's disease and its clinical implications[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(3): 131-138.

徐滢, 桂雅星. 脂质代谢异常对帕金森病进程的影响及临床意义[J]. 中国现代神经疾病杂志, 2024, 24(3): 131-138.

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