Pathogenesis and treatment of Parkinson's disease with camptocormia

doi:10.3969/j.issn.1672-6731.2024.03.006

Abstract

Abstract:

Postural disorder is a common disabling movement complication of Parkinson's disease (PD), in which camptocormia is the most common disabling postural disorder, which further aggravates the movement disorder of PD, and seriously reduces the activities of daily living and quality of life of patients. This paper reviews the pathogenesis and treatment progress of PD with camptocormia, providing theoretical basis for further investigation of the pathogenesis of camptocormia in PD, and assisting the clinical diagnosis and treatment of the disease.

Key words: Parkinson disease, Postural balance, Torso, Review

摘要：

姿势障碍是帕金森病的常见致残性运动症状，其中躯干前屈症是最常见的姿势障碍，可加重帕金森病运动障碍，严重降低患者日常生活活动能力和生活质量。本文综述帕金森病躯干前屈症的发病机制及治疗进展，为深入探究其发病机制提供理论依据并辅助临床诊断与治疗。

关键词: 帕金森病, 姿势平衡, 躯干, 综述

Yi-qing BI, Feng-juan WU, Yu-gang ZHU, Yi-ming LIU. Pathogenesis and treatment of Parkinson's disease with camptocormia[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(3): 146-150.

毕怡青, 吴凤娟, 朱玉港, 刘艺鸣. 帕金森病躯干前屈症发病机制及治疗[J]. 中国现代神经疾病杂志, 2024, 24(3): 146-150.

/ / Recommend / Download Citations

URL: https://journal11.magtechjournal.com/cjcnn/EN/10.3969/j.issn.1672-6731.2024.03.006

https://journal11.magtechjournal.com/cjcnn/EN/Y2024/V24/I3/146

References 51

1	Ali F , Matsumoto JY , Hassan A . Camptocormia: etiology, diagnosis, and treatment response. Neurol Clin Pract, 2018, 8: 240- 248. doi: 10.1212/CPJ.0000000000000453
2	Ando Y , Fujimoto KI , Ikeda K , Utsumi H , Okuma Y , Oka H , Kamei S , Kurita A , Takahashi K , Nogawa S , Hattori N , Hirata K , Fukui T , Yamazaki K , Yamamoto T , Yoshii F . Postural abnormality in Parkinson's disease: a large comparative study with general population. Mov Disord Clin Pract, 2019, 6: 213- 221. doi: 10.1002/mdc3.12723
3	Abe K , Uchida Y , Notani M . Camptocormia in Parkinson's disease. Parkinsons Dis, 2010, 267640.
4	Pongmala C , Artusi CA , Zibetti M , Pitakpatapee Y , Wangthumrong T , Sangpeamsook T , Srikajon J , Srivanitchapoom P , Youn J , Cho JW , Kim M , Zamil Shinawi HM , Obaid MT , Baumann A , Margraf NG , Pona-Ferreira F , Leitão M , Lobo T , Ferreira JJ , Fabbri M , Lopiano L . Postural abnormalities in Asian and Caucasian Parkinson's disease patients: a multicenter study. Parkinsonism Relat Disord, 2022, 97: 91- 98. doi: 10.1016/j.parkreldis.2022.03.006
5	Tinazzi M , Gandolfi M , Ceravolo R , Capecci M , Andrenelli E , Ceravolo MG , Bonanni L , Onofrj M , Vitale M , Catalan M , Polverino P , Bertolotti C , Mazzucchi S , Giannoni S , Smania N , Tamburin S , Vacca L , Stocchi F , Radicati FG , Artusi CA , Zibetti M , Lopiano L , Fasano A , Geroin C . Postural abnormalities in Parkinson's disease: an epidemiological and clinical multicenter study. Mov Disord Clin Pract, 2019, 6: 576- 585. doi: 10.1002/mdc3.12810
6	Margraf NG , Granert O , Hampel J , Wrede A , Schulz-Schaeffer WJ , Deuschl G . Clinical definition of camptocormia in Parkinson's disease. Mov Disord Clin Pract, 2016, 4: 349- 357.
7	Tinazzi M , Geroin C , Bhidayasiri R , Bloem BR , Capato T , Djaldetti R , Doherty K , Fasano A , Tibar H , Lopiano L , Margraf NG , Merello M , Moreau C , Ugawa Y , Artusi CA , International Parkinson and Movement Disorders Society Task Force on Postural Abnormalities . Task force consensus on nosology and cut-off values for axial postural abnormalities in parkinsonism. Mov Disord Clin Pract, 2022, 9: 594- 603. doi: 10.1002/mdc3.13460
8	Srivanitchapoom P , Hallett M . Camptocormia in Parkinson's disease: definition, epidemiology, pathogenesis and treatment modalities. J Neurol Neurosurg Psychiatry, 2016, 87: 75- 85.
9	Wolke R , Kuhtz-Buschbeck JP , Deuschl G , Margraf NG . Insufficiency of trunk extension and impaired control of muscle force in Parkinson's disease with camptocormia. Clin Neurophysiol, 2020, 131: 2621- 2629. doi: 10.1016/j.clinph.2020.07.019
10	Carpenter MG , Bloem BR . Postural control in Parkinson patients: a proprioceptive problem?. Exp Neurol, 2011, 227: 26- 30. doi: 10.1016/j.expneurol.2010.11.007
11	Wright WG , Gurfinkel VS , King LA , Nutt JG , Cordo PJ , Horak FB . Axial kinesthesia is impaired in Parkinson's disease: effects of levodopa. Exp Neurol, 2010, 225: 202- 209. doi: 10.1016/j.expneurol.2010.06.016
12	Schulz-Schaeffer WJ . Camptocormia in Parkinson's disease: a muscle disease due to dysregulated proprioceptive polysynaptic reflex arch. Front Aging Neurosci, 2016, 8: 128.
13	Wrede A , Margraf NG , Goebel HH , Deuschl G , Schulz-Schaeffer WJ . Myofibrillar disorganization characterizes myopathy of camptocormia in Parkinson's disease. Acta Neuropathol, 2012, 123: 419- 432. doi: 10.1007/s00401-011-0927-7
14	Karpati G , Carpenter S , Eisen AA . Experimental core-like lesions and nemaline rods: a correlative morphological and physiological study. Arch Neurol, 1972, 27: 237- 251. doi: 10.1001/archneur.1972.00490150045008
15	Bertolini G , Wicki A , Baumann CR , Straumann D , Palla A . Impaired tilt perception in Parkinson's disease: a central vestibular integration failure. PLoS One, 2015, 10: e0124253. doi: 10.1371/journal.pone.0124253
16	Bong SM , McKay JL , Factor SA , Ting LH . Perception of whole-body motion during balance perturbations is impaired in Parkinson's disease and is associated with balance impairment. Gait Posture, 2020, 76: 44- 50. doi: 10.1016/j.gaitpost.2019.10.029
17	Grütz K , Klein C . Dystonia updates: definition, nomenclature, clinical classification, and etiology. J Neural Transm (Vienna), 2021, 128: 395- 404. doi: 10.1007/s00702-021-02314-2
18	Stoessl AJ , Lehericy S , Strafella AP . Imaging insights into basal ganglia function, Parkinson's disease, and dystonia. Lancet, 2014, 384: 532- 544. doi: 10.1016/S0140-6736(14)60041-6
19	Kataoka H , Ueno S . Can postural abnormality really respond to levodopa in Parkinson's disease?. J Neurol Sci, 2017, 377: 179- 184. doi: 10.1016/j.jns.2017.04.025
20	Kataoka H , Sawada Y , Namizaki T , Shimozato N , Yoshiji H , Ueno S . Intrajejunal infusion of levodopa-carbidopa gel can continuously reduce the severity of dropped head in Parkinson's disease. Front Neurol, 2017, 8: 547. doi: 10.3389/fneur.2017.00547
21	Galati S , Möller JC , Städler C . Ropinirole-induced Pisa syndrome in Parkinson disease. Clin Neuropharmacol, 2014, 37: 58- 59. doi: 10.1097/WNF.0000000000000022
22	Yoritaka A , Shimo Y , Takanashi M , Fukae J , Hatano T , Nakahara T , Miyamato N , Urabe T , Mori H , Hattori N . Motor and non-motor symptoms of 1453 patients with Parkinson's disease: prevalence and risks. Parkinsonism Relat Disord, 2013, 19: 725- 731. doi: 10.1016/j.parkreldis.2013.04.001
23	Mehta S , Kumar R , Lal V . An unusual cause of camptocormia. Tremor Other Hyperkinet Mov (NY), 2019, 9: 608. doi: 10.5334/tohm.492
24	Margraf NG , Rohr A , Granert O , Hampel J , Drews A , Deuschl G . MRI of lumbar trunk muscles in patients with Parkinson's disease and camptocormia. J Neurol, 2015, 262: 1655- 1664. doi: 10.1007/s00415-015-7726-3
25	Magrinelli F , Geroin C , Squintani G , Gandolfi M , Rizzo G , Barillari M , Vattemi G , Morgante F , Tinazzi M . Upper camptocormia in Parkinson's disease: neurophysiological and imaging findings of both central and peripheral pathophysiological mechanisms. Parkinsonism Relat Disord, 2020, 71: 28- 34. doi: 10.1016/j.parkreldis.2020.01.004
26	Nakane S , Yoshioka M , Oda N , Tani T , Chida K , Suzuki M , Funakawa I , Inukai A , Hasegawa K , Kuroda K , Mizoguchi K , Shioya K , Sonoda Y , Matsuo H . The characteristics of camptocormia in patients with Parkinson's disease: a large cross-sectional multicenter study in Japan. J Neurol Sci, 2015, 358: 299- 303. doi: 10.1016/j.jns.2015.09.015
27	Menšíková K , Kaiserová M , Vaštík M , Nevrlý M , Kurčová S , Kaňovský P , Colosimo C . The long-term effect of continuous subcutaneous apomorphine infusions on camptocormia in Parkinson's disease. Parkinsonism Relat Disord, 2020, 75: 14- 16. doi: 10.1016/j.parkreldis.2020.05.015
28	Fabbri M , Pongmala C , Artusi CA , Imbalzano G , Romagnolo A , Lopiano L , Zibetti M . Video analysis of long-term effects of levodopa-carbidopa intestinal gel on gait and posture in advanced Parkinson's disease. Neurol Sci, 2020, 41: 1927- 1930. doi: 10.1007/s10072-020-04319-3
29	Charpentier P , Dauphin A , Stojkovic T , Cotten A , Hurtevent JF , Maurage CA , Thévenon A , Destée A , Defebvre L . Parkinson's disease, progressive lumbar kyphosis and focal paraspinal myositis. Rev Neurol (Paris), 2005, 161: 459- 463. doi: 10.1016/S0035-3787(05)85077-5
30	Brotini S . Palmitoylethanolamide/luteolin as adjuvant therapy to improve an unusual case of camptocormia in a patient with Parkinson's disease: a case report. Innov Clin Neurosci, 2021, 18: 12- 14.
31	Jenner P , Mori A , Aradi SD , Hauser RA . Istradefylline: a first generation adenosine A2A antagonist for the treatment of Parkinson's disease. Expert Rev Neurother, 2021, 21: 317- 333. doi: 10.1080/14737175.2021.1880896
32	Jost WH . Use of botulinum neurotoxin in Parkinson's disease: a critical appraisal. Toxins (Basel), 2021, 13: 87. doi: 10.3390/toxins13020087
33	Anandan C , Jankovic J . Botulinum toxin in movement disorders: an update. Toxins (Basel), 2021, 13: 42. doi: 10.3390/toxins13010042
34	Furusawa Y , Mukai Y , Kawazoe T , Sano T , Nakamura H , Sakamoto C , Iwata Y , Wakita M , Nakata Y , Kamiya K , Kobayashi Y , Sakamoto T , Takiyama Y , Murata M . Long-term effect of repeated lidocaine injections into the external oblique for upper camptocormia in Parkinson's disease. Parkinsonism Relat Disord, 2013, 19: 350- 354. doi: 10.1016/j.parkreldis.2012.09.008
35	Kim SH , Yun SJ , Dang QK , Chee Y , Chung SG , Oh BM , Kim K , Seo HG . Measurement and correction of stooped posture during gait using wearable sensors in patients with Parkinsonism: a preliminary study. Sensors (Basel), 2021, 21: 2379. doi: 10.3390/s21072379
36	Pérennou D , Dai S , Gastaldi R , Fraix V , Leroux N , Clarac E , Davoine P , Piscicelli C , Krack P . Retropulsion with tilted postural vertical causing backward falls in an individual with Parkinson's disease: improvement by specific rehabilitation. Ann Phys Rehabil Med, 2023, 66: 101728. doi: 10.1016/j.rehab.2022.101728
37	Sakai T , Nagai S , Takao K , Tsuchiyama H , Ikeda K . Effect of intramuscular lidocaine injection with physical therapy on camptocormia in patients with Parkinson's disease who had previously had deep brain stimulation. J Phys Ther Sci, 2023, 35: 66- 69. doi: 10.1589/jpts.35.66
38	Lai Y , Song Y , Huang P , Wang T , Wang L , Pan Y , Sun Q , Sun B , Zhang C , Li D . Subthalamic stimulation for camptocormia in Parkinson's disease: association of volume of tissue activated and structural connectivity with clinical effectiveness. J Parkinsons Dis, 2021, 11: 199- 210. doi: 10.3233/JPD-202259
39	Liang S , Yu Y , Li H , Wang Y , Cheng Y , Yang H . The study of subthalamic deep brain stimulation for Parkinson disease: associated camptocormia. Med Sci Monit, 2020, 26: e919682.
40	Schulz-Schaeffer WJ , Margraf NG , Munser S , Wrede A , Buhmann C , Deuschl G , Oehlwein C . Effect of neurostimulation on camptocormia in Parkinson's disease depends on symptom duration. Mov Disord, 2015, 30: 368- 372. doi: 10.1002/mds.26081
41	Sakai W , Nakane S , Urasaki E , Toyoda K , Sadakata E , Nagaishi A , Fukudome T , Yamakawa Y , Matsuo H . The cross-sectional area of paraspinal muscles predicts the efficacy of deep drain stimulation for camptocormia. J Parkinson Dis, 2017, 7: 247- 253. doi: 10.3233/JPD-160948
42	Lai Y , Song Y , Su D , Wang L , Zhang C , Sun B , Nonnekes J , Bloem BR , Li D . Pallidal stimulation as treatment for camptocormia in Parkinson's disease. NPJ Parkinsons Dis, 2021, 7: 8. doi: 10.1038/s41531-020-00151-w
43	Sławek J , Derejko M , Lass P . Camptocormia as a form of dystonia in Parkinson's disease. Eur J Neurol, 2003, 10: 107- 108. doi: 10.1046/j.1468-1331.2003.00503_1.x
44	Akiyama H , Nukui S , Akamatu M , Hasegawa Y , Nishikido O , Inoue S . Effectiveness of spinal cord stimulation for painful camptocormia with Pisa syndrome in Parkinson's disease: a case report. BMC Neurol, 2017, 17: 148. doi: 10.1186/s12883-017-0926-y
45	Arii Y , Sawada Y , Kawamura K , Miyake S , Taichi Y , Izumi Y , Kuroda Y , Inui T , Kaji R , Mitsui T . Immediate effect of spinal magnetic stimulation on camptocormia in Parkinson's disease. J Neurol Neurosurg Psychiatry, 2014, 85: 1221- 1226. doi: 10.1136/jnnp-2014-307651
46	Smith PF . Vestibular functions and Parkinson's disease. Front Neurol, 2018, 9: 1085. doi: 10.3389/fneur.2018.01085
47	Kataoka H , Okada Y , Kiriyama T , Kita Y , Nakamura J , Shomoto K , Sugie K . Effect of galvanic vestibular stimulation on axial symptoms in Parkinson's disease. J Cent Nerv Syst Dis, 2022, 14: 11795735221081599.
48	Lee S , Liu A , McKeown MJ . Current perspectives on galvanic vestibular stimulation in the treatment of Parkinson's disease. Expert Rev Neurother, 2021, 21: 405- 418. doi: 10.1080/14737175.2021.1894928
49	Dávalos-Yerovi V , Romeo A , Escalada F , Tejero M . Postural effect of vestibular galvanic stimulation in patients with Parkinson's disease and camptocormia: case series. Rehabilitacion (Madr), 2022, 56: 78- 81. doi: 10.1016/j.rh.2021.11.002
50	Park HY , Ha KY , Kim YH , Oh IS , Chang DG , Kim SI , Jeon WK , Kim GU . Spinal surgery for Parkinson disease with camptocormia: propensity score-matched cohort study with Degenerative Sagittal Imbalance (DSI). Clin Spine Surg, 2020, 33: E563- 571. doi: 10.1097/BSD.0000000000000994
51	Mei GL , Wei HT , Ma YR , Wan D . Surgical correction of kyphosis in patients with camptocormia associated with Parkinson's disease: a case report and review of the literature. Front Surg, 2022, 9: 822015. doi: 10.3389/fsurg.2022.822015

[1]	Zhi-yong TONG. Intracranial aneurysms and cerebral revascularization [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(8): 595-598.
[2]	Zhi-yong TONG. History of cerebral revascularization [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(8): 599-605.
[3]	Ling-ji JIN, Jun-wen HU, Yin LI, Lin WANG. Intracranial-intracranial bypass for the treatment of complex intracranial aneurysms: technical advances and surgical experience [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(8): 606-612.
[4]	Pei-xi LIU, Yuan SHI, Wei ZHU. Application of whole-region cerebral vascular bypass for intracranial aneurysms treatment in the flow diversion era [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(8): 613-618.
[5]	Feng ZHANG, Fan-gang MENG. Research progress of subthalamic nucleus deep brain stimulation in treatment of autonomic nerve dysfunction in Parkinson's disease [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 510-515.
[6]	Gui-zhi WU, Hong TIAN. Clinical research progress of deep brain stimulation for Meige's syndrome [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 516-521.
[7]	Fan-gang MENG, Jian-guo ZHANG. Application of retroauricular bone grinding groove technology in deep brain stimulation [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 522-524.
[8]	Bo-wen CHANG, Jia-ming MEI, Chi XIONG, Peng CHEN, Man-li JIANG, Chao-shi NIU. Functional connectivity analysis in the brain of subthalamic nucleus deep brain stimulation in the improvement of depression in Parkinson's disease [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 532-539.
[9]	Yi-feng CHENG, Shao-ya YIN, De-qiu CUI, Chun-juan WANG, Guang-rui ZHAO, Ke-ke FENG. Long-term follow-up study of variable frequency stimulation mode deep brain stimulation for axial symptoms in Parkinson's disease [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 547-554.
[10]	Ping HE, Xin XU, Zhi-pei LING. Early-onset Parkinson's disease long-term followed up after subthalamic nucleus deep brain stimulation: one case report [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 555-558.
[11]	Min TU, Shuang-feng YANG, Yu-ling TAN, Xiao-ming WANG. Correlation analysis of retinal characteristics and disease severity in Parkinson's disease [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 559-566.
[12]	Lin CHEN, Hua PAN. Electrophysiological diagnosis of functional tremor [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(7): 573-578.
[13]	Jun-ji WEI, Jian-bo CHANG. Promoting the concept of neurosurgical critical care in primary hospitals [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(6): 403-406.
[14]	Ruo-lin SHI, Xiu-jie GAO, Jia-ning CUI, Yan SHAO, Lu-shuang XIE, Yi LIU. Advance on association between 5-hydroxytryptamine and non-motor symptoms in Parkinson's disease [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(6): 497-501.
[15]	Hai-feng LI. Glucocorticoids remain the basis for treatment of myasthenia gravis in the era of targeted therapies [J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2024, 24(5): 295-307.

Please choose a citation manager

Content to export