生长激素在颅脑创伤的应用进展

doi:10.3969/j.issn.1672-6731.2025.09.004

中国现代神经疾病杂志 ›› 2025, Vol. 25 ›› Issue (9): 798-806. doi: 10.3969/j.issn.1672-6731.2025.09.004

2 生长激素在颅脑创伤的应用进展

廖希贤¹, 梅芬², 邱炳辉², 漆松涛², 钟晴蕾³, 包贇²^,*()

1. 100070 首都医科大学附属北京天坛医院神经外科
2. 510515 广州，南方医科大学南方医院神经外科
3. 510515 广州，南方医科大学第一临床医学院2023级

收稿日期:2025-06-19 出版日期:2025-09-25 发布日期:2025-10-17
通讯作者: 包贇
基金资助:
广东省基础与应用基础研究基金项目(2024A1515030069); 南方医科大学攀登计划项目(pdjh2024b092); 南方医科大学南方医院临床研究专项(2023CR023); 南方医科大学南方医院院长基金项目(2022Y001)

Progress on the application of growth hormone in traumatic brain injury

Xi-xian LIAO¹, Fen MEI², Bing-hui QIU², Song-tao QI², Qing-lei ZHONG³, Yun BAO²^,*()

1. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
2. Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China
3. Grade 2023, The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China

Received:2025-06-19 Online:2025-09-25 Published:2025-10-17
Contact: Yun BAO
Supported by:
Guangdong Basic and Applied Basic Research Foundation(2024A1515030069); Climbing Program Project of Southern Medical University(pdjh2024b092); Clinical Research Program of Nanfang Hospital, Southern Medical University(2023CR023); President Foundation of Nanfang Hospital, Southern Medical University(2022Y001)

摘要/Abstract

摘要：

颅脑创伤后垂体功能障碍日益获得关注，生长激素缺乏症是最常见亚型。对颅脑创伤后生长激素缺乏患者予以生长激素替代治疗可以有效改善认知功能等预后。本文综述颅脑创伤后生长激素缺乏的病理生理学机制、生长激素治疗颅脑创伤的作用机制及相关临床研究进展，为生长激素在颅脑创伤治疗中的应用提供理论指导。

关键词: 脑损伤，创伤性, 垂体功能减退症, 生长激素, 综述

Abstract:

Pituitary dysfunction after traumatic brain injury (TBI) has increasingly attracted attention, with growth hormone deficiency (GHD) being the most common subtype. The use of growth hormone (GH) replacement therapy for patients with GHD after TBI has a positive impact on prognosis, including cognitive improvement, and so on. This article reviews the mechanisms of pathophysiology of GHD, the mechanisms of GH treatment for TBI and the current status of clinical application, and proposes future development directions to provide the theoretical guidance for the application of GH in the treatment of GHD after TBI.

Key words: Brain injuries, traumatic, Hypopituitarism, Growth hormone, Review

廖希贤, 梅芬, 邱炳辉, 漆松涛, 钟晴蕾, 包贇. 生长激素在颅脑创伤的应用进展[J]. 中国现代神经疾病杂志, 2025, 25(9): 798-806.

Xi-xian LIAO, Fen MEI, Bing-hui QIU, Song-tao QI, Qing-lei ZHONG, Yun BAO. Progress on the application of growth hormone in traumatic brain injury[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2025, 25(9): 798-806.

https://journal11.magtechjournal.com/cjcnn/CN/Y2025/V25/I9/798

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