脑静脉系统疾病相关炎症机制与干预靶点

doi:10.3969/j.issn.1672-6731.2025.06.003

摘要/Abstract

摘要：

炎症在脑静脉系统疾病的发生发展、诊断、治疗监测及预后评估中扮演重要角色，炎症标志物的应用为脑静脉系统疾病提供重要的治疗监测和预后评估工具。总结炎症在脑静脉系统疾病发生发展中的病理生理学机制、了解其在诊断与治疗中的应用价值及其与预后的关系，揭示炎症在脑静脉系统疾病中的多维作用，并提出未来研究方向和建议，旨在为脑静脉系统疾病的临床管理和机制探索提供更多的方向。

关键词: 静脉血栓形成, 脑静脉, 颅窦, 缩窄，病理性, 炎症, 生物标记, 综述

Abstract:

Inflammation plays a crucial role in the pathogenesis, diagnosis, treatment monitoring and prognosis assessment of cerebral venous system diseases. The application of inflammatory biomarkers provides important treatment monitoring and prognosis assessment tools for cerebral venous system diseases. Summarizing the pathophysiological mechanisms of inflammation in the development of cerebral venous system diseases, understanding its application value in the diagnosis and treatment, as well as its relationship with the prognosis of cerebral venous system diseases, reveals the multi? dimensional role of inflammation in cerebral venous system diseases. Additionally, proposing future research directions and suggestions can offer more insights for the clinical management and mechanistic exploration of cerebral venous system diseases.

Key words: Venous thrombosis, Cerebral veins, Cranial sinuses, Constriction, pathologic, Inflammation, Biomarkers, Review

阮玉爽, 董子康, 方芝, 夏远鹏. 脑静脉系统疾病相关炎症机制与干预靶点[J]. 中国现代神经疾病杂志, 2025, 25(6): 470-476.

Yu-shuang RUAN, Zi-kang DONG, Zhi FANG, Yuan-peng XIA. Inflammatory mechanisms and therapeutic targets in cerebral venous system diseases[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2025, 25(6): 470-476.

https://journal11.magtechjournal.com/cjcnn/CN/Y2025/V25/I6/470

图/表 1

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炎症标志物	病理生理学机制	预后评估	治疗靶点
TNF-α	诱导血管内皮细胞凋亡，加剧血脑屏障破坏	与不良预后相关	TNF-α抑制剂（如英夫利昔单抗）
IL-6	促进凝血和炎症级联反应	与不良预后相关	IL-6抑制剂
IL-1β	促进凝血和炎症级联反应	与不良预后相关	IL-1β抑制剂
CRP	反映全身炎症状态	与不良预后相关	—
NLR	反映全身炎症状态，并与疾病严重程度相关	与不良预后相关	—
LMR	反映全身炎症状态，并与疾病严重程度相关	与不良预后相关	—
MLR	反映全身炎症状态，并与疾病严重程度相关	与不良预后相关	—
PLR	反映全身炎症状态，并与疾病严重程度相关	与不良预后相关	—
HMGB1	作为损伤相关分子模式激活炎症小体，加剧损伤	—	HMGB1抑制剂
NLRP3炎症小体	通过损伤相关分子模式激活并促进神经元焦亡	—	NLRP3抑制剂
VEGF	表达上调可能与脑静脉窦狭窄并发的硬脑膜动静脉瘘形成有关	—	VEGF抑制剂
PDGF	表达上调可能与脑静脉窦狭窄并发的硬脑膜动静脉瘘形成有关	—	PDGF抑制剂

炎症标志物	病理生理学机制	预后评估	治疗靶点
TNF-α	诱导血管内皮细胞凋亡，加剧血脑屏障破坏	与不良预后相关	TNF-α抑制剂（如英夫利昔单抗）
IL-6	促进凝血和炎症级联反应	与不良预后相关	IL-6抑制剂
IL-1β	促进凝血和炎症级联反应	与不良预后相关	IL-1β抑制剂
CRP	反映全身炎症状态	与不良预后相关	—
NLR	反映全身炎症状态，并与疾病严重程度相关	与不良预后相关	—
LMR	反映全身炎症状态，并与疾病严重程度相关	与不良预后相关	—
MLR	反映全身炎症状态，并与疾病严重程度相关	与不良预后相关	—
PLR	反映全身炎症状态，并与疾病严重程度相关	与不良预后相关	—
HMGB1	作为损伤相关分子模式激活炎症小体，加剧损伤	—	HMGB1抑制剂
NLRP3炎症小体	通过损伤相关分子模式激活并促进神经元焦亡	—	NLRP3抑制剂
VEGF	表达上调可能与脑静脉窦狭窄并发的硬脑膜动静脉瘘形成有关	—	VEGF抑制剂
PDGF	表达上调可能与脑静脉窦狭窄并发的硬脑膜动静脉瘘形成有关	—	PDGF抑制剂

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2 脑静脉系统疾病相关炎症机制与干预靶点

Inflammatory mechanisms and therapeutic targets in cerebral venous system diseases

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Inflammatory mechanisms and therapeutic targets in cerebral venous system diseases

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