摘要：

目的: 筛查脑静脉血栓形成患者颅内压增高相关影响因素。方法: 纳入2021年2月至2023年2月复旦大学附属华山医院诊断与治疗的102例脑静脉血栓形成患者，均行腰椎穿刺脑脊液检查，采用单因素和多因素Logistic回归分析筛查颅内压增高相关影响因素。结果: 共102例患者根据腰椎穿刺脑脊液压力分为颅内压正常组（< 200 mm H₂O，17例）和颅内压增高组（≥ 200 mm H₂O，85例），颅内压增高组血红蛋白（P = 0.027）和发病至腰椎穿刺时间（P = 0.042）低于颅内压正常组，脑静脉血栓负荷评分高于颅内压正常组（P = 0.000）。Logistic回归分析显示，脑静脉血栓负荷大是脑静脉血栓形成患者颅内压增高的独立危险因素（OR = 2.956，95%CI：1.445 ~ 6.048；P = 0.003）。结论: 脑静脉血栓负荷对脑静脉血栓形成患者的颅内压影响较大。

关键词: 静脉血栓形成, 脑静脉, 颅内压, 危险因素, Logistic模型

Abstract:

Objective: To screen the influencing factors for increased intracranial pressure (ICP) in patients with cerebral venous thrombosis (CVT). Methods: A total of 102 patients with CVT admitted to Huashan Hospital, Fudan University from February 2021 to February 2023 were included. All patients underwent lumbar puncture cerebrospinal fluid examination. The clinical data of the patients were analyzed, and univariate and multivariate stepwise Logistic regression analyses were used to screen the influencing factors for increased ICP. Results: According to the lumbar puncture cerebrospinal fluid pressure value, the patients were divided into normal ICP group (< 200 mm H₂O, n = 17) and increased ICP group (≥ 200 mm H₂O, n = 85). The increased ICP group had lower hemoglobin (P = 0.027) and time from onset to lumbar puncture (P = 0.042), and higher CVT burden score (P = 0.000) than normal ICP group. Logistic regression analysis showed that large CVT burden was a independent risk factor for increased ICP in patients with CVT (OR = 2.956, 95%CI: 1.445-6.048; P = 0.003). Conclusions: The CVT burden has a significant impact on ICP in patients with CVT.

Key words: Venous thrombosis, Cerebral veins, Intracranial pressure, Risk factors, Logistic models