中国现代神经疾病杂志 ›› 2021, Vol. 21 ›› Issue (3): 223-228. doi: 10.3969/j.issn.1672-6731.2021.03.016

• 综述 • 上一篇    下一篇

2 钠-钾-氯协同转运蛋白1相关神经系统疾病研究进展

付旭阳1, 孙健淇2, 吕军3, 石瑞丽3   

  1. 1. 014040 包头, 内蒙古科技大学基础与法医学院 2018级;
    2. 014030 包头, 内蒙古科技大学第二附属医院药剂科;
    3. 014040 包头, 内蒙古科技大学生理学教研室
  • 收稿日期:2021-02-26 出版日期:2021-03-25 发布日期:2021-04-02
  • 通讯作者: 石瑞丽,Email:ruilishi@sina.com
  • 基金资助:

    国家自然科学基金资助项目(项目编号:81960734);内蒙古自治区自然科学基金资助项目(项目编号:2017MS0808);内蒙古自治区高等学校科学研究项目(项目编号:NJZC17244)

Research progress on Na+-K+-2Cl- cotransporter 1 and its relationship to nervous system diseases

FU Xu-yang1, SUN Jian-qi2, LÜ Jun3, SHI Rui-li3   

  1. 1 Grade 2018 of College of Basic Medicine and Forensic Medicine, Inner Mongolia University of Science and Technology, Baotou 014040, Inner Mongolia, China;
    2 Department of Pharmacy, The Second Affiliated Hospital of Inner Mongolia University of Science and Technology, Baotou 014030, Inner Mongolia, China;
    3 Department of Physiology, Inner Mongolia University of Science and Technology, Baotou 014040, Inner Mongolia, China
  • Received:2021-02-26 Online:2021-03-25 Published:2021-04-02
  • Supported by:

    This study was supported by the National Natural Science Foundation of China (No. 81960734), Inner Mongolia Autonomous Region Natural Science Foundation (No. 2017MS0808), and Inner Mongolia Autonomous Region Higher Education Scientific Research Project (No. NJZC17244).

摘要:

钠-钾-氯协同转运蛋白1(NKCC1)是阳离子-氯化物协同转运蛋白之一,为介导钠、钾、氯离子转运的膜蛋白,对保持氯离子动态平衡至关重要。病理状态下NKCC1表达或活性发生变化,进而调节氯离子细胞内浓度和神经元兴奋性。本文拟对NKCC1表达及活性调节方式,以及NKCC1在多种神经系统疾病发病机制、治疗中的作用进行综述,以为后续相关研究提供理论线索。

关键词: 钠钾氯化物协同转运子, DNA甲基化, γ氨基丁酸, 神经系统疾病, 综述

Abstract:

Na+-K+-2Cl- cotransporter 1 (NKCC1) which plays an important role in the dynamic balance of Cl- ions, is one of the cation-chloride cotransporter. It is a membrane protein that transferred the mediates Na+, K+ and Cl-. The expression quantity or activity of NKCC1 changes with the changes in physiological and pathological conditions, thereby regulating the intracellular concentration of Cl- and the excitability of neurons. This article reviews the NKCC1's expression and regulation mode of activity as well as the effects of NKCC1 in the pathogenesis of various neurological diseases and the effects in the treatment, aiming at providing theoretical clues for the relevant future studies.

Key words: Sodium-potassium-chlorine symporters, DNA methylation, gamma-aminobutyric acid, Nervous system diseases, Review