Abstract: Osteoporosis is a disease characterized by decreased bone mass and increased bone fragility. The osteogenic differentiation of osteoblasts and the mineralization of extracellular matrix are important processes of bone mass maintenance .And this process is regulated by multiple intracellular signal transduction pathways. This article reviews the major pathways related to bone metabolism, including Wnt, BMP, RANKL and NOTCH signaling pathways, and the key molecules involved in these pathways. By intervening the activation of these pathways, bone metabolism can be regulated. And this provides a new target for the treatment of osteoporosis.

Key words: osteoporosis, signaling pathways, mechanism, progress