Role of hydrogen sulfide in asthma

doi:10.16352/j.issn.1001-6325.2025.09.1239

Abstract

Abstract: Asthma is one of the most common diseases in chronic respiratory system; the etiology is complex, involving many types of inflammatory cells and a variety of signaling molecular mediators. Hydrogen sulfide (H₂S) is an endogenous gas transmitter in mammals, which is widely involved in cell functions and physiological and pathological processes of various diseases, including respiratory diseases. H₂S is involved in the occurrence and development of asthma through various ways. When the H₂S-producing enzyme level decreases, the concentration of endogenous H₂S level may trigger asthma attack and play a pro-inflammatory role. On the other hand, H₂S initiates pulmonary inducible nitric oxide synthase (iNOS) activation, limiting airway remodeling, and acts as an anti-remodeling and anti-inflammatory mediator. Moreover, H₂S level varies at different stages of asthma. H₂S level in patients with asthma is a potential bio-markers of airway inflammation in asthma case and my support clinical diagnosis of asthma.

Key words: hydrogen sulfide, asthma, mechanism of action, biomarker

CLC Number:

R563
R446

CUI Xinyue, HAN Shasha. Role of hydrogen sulfide in asthma[J]. Basic & Clinical Medicine, 2025, 45(9): 1239-1242.

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