Basic & Clinical Medicine ›› 2025, Vol. 45 ›› Issue (2): 258-262.doi: 10.16352/j.issn.1001-6325.2025.02.0258

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Role of transmembrane protein 33 in tumorigenesis and development

LOU Haijun1, MENG Menggen2, ZHANG Zhenyu1, TONG Zhuoyun1, WUDU Muli1 *   

  1. 1. Department of Pathology, School of Basic Medicine;
    2. Department of Clinical Laboratory, the Fifth Clinical College of Medicine, Xinjiang Medical University, Urumqi 830017,China
  • Received:2024-02-20 Revised:2024-07-05 Online:2025-02-05 Published:2025-01-17
  • Contact: *wudumuli@xjmu.edu.cn

Abstract: Transmembrane protein 33 (TMEM33) is up-regulated in the majority of cancers. To change the expression of TMEM33 can significantly affect the proliferation, migration, and invasion of renal and cervical cancer cells. Its mechanisms of action may involve four aspects: 1)participation in lipid metabolism; 2)regulation of endoplasmic reticulum; 3)regulation of intracellular calcium homeostasis; 4) participation in angiogenesis.

Key words: transmembrane protein 33, tumor development, tumor metastasis, biomarker, therapeutic target

CLC Number: