Basic & Clinical Medicine ›› 2025, Vol. 45 ›› Issue (2): 148-153.doi: 10.16352/j.issn.1001-6325.2025.02.0148

• Special Issues: Cardiovascular and Cerebrovascular Diseases • Previous Articles     Next Articles

Research progress on the interaction between osteoarthritis and cardiovascular diseases

YANG Jianfeng, HAO Lin, WANG Yan, JI Quanbo*   

  1. Department of Orthopaedics, the General Hospital of Chinese PLA, Beijing 100853, China
  • Received:2024-11-05 Revised:2024-11-25 Online:2025-02-05 Published:2025-01-17
  • Contact: *quanbo301@163.com

Abstract: Osteoarthritis (OA) is closely related to cardiovascular disease (CVD). The incidence of CVD is significantly higher in the population of OA patients. This review first analyzes the epidemiology and common risk factors of OA and CVD, then discusses the pathogenesis of OA and CVD, and clarifies the roles of chronic low-grade inflammation, metabolic syndrome, endothelial dysfunction, as well as macrophages, T-cells, and inflammatory factors involved in the mechanisms of interaction between OA and CVD. The review further analyzes treatment strategies and preventive measures for OA and CVD, explores the impact of OA treatment drugs on cardiovascular safety, and elucidates the importance of cardiovascular risk assessment and management in OA patients for clinical diagnosis and treatment. Finally, this review orientes future research directions of OA and CVD, including in-depth exploration of the molecular and cellular mechanisms between OA and CVD, drug interactions, and the development of new treatment strategies, aiming to provide ideas for improving the clinical diagnosis, treatment and prognosis of OA and CVD.

Key words: osteoarthritis, cardiovascular disease, mechanism, treatment, prevention

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