Abstract: Objective To investigate the correlation between coagulation system biomarkers and bone mineral density (BMD) in patients with spinal degenerative diseases. Methods A total of 251 patients who underwent surgical treatment for spinal degenerative diseases at the Department of Spinal Surgery, Beijing Jishuitan Hospital, from March to October 2019, were enrolled in this study. These patients had both BMD data and coagulation system test Results available. The distribution of coagulation indicators, including prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen(Fib), and thrombin time (TT), was analyzed across different gender and BMD groups. Results A retrospective analysis of laboratory coagulation indicators revealed that in male patients, only fibrinogen levels were significantly increased with the reduction of BMD (P＜0.05). PTand APTT did′t show significant differences in female patients across BMD groups, but fibrinogen levels increased with the decrease in BMD (P＜0.05). Patients were classified into osteoporosis and non-osteoporosis groups based on their BMD Results. Pearson correlation analysis was performed between the binary variable of BMD grouping and patients′ coagulation indicators. TheResults showed a significant negative correlation between BMD grouping and fibrinogen levels in both genders (P＜0.05). Conclusions Fibrinogen level in patients with spinal degenerative diseases significantly increases as BMD decreases, suggesting that fibrinogen may serve as a predictive biomarker for BMD stratification in these patients.

Key words: fibrinogen, osteoporosis, spinal degenerative disease