组氨酸磷酸酶在某些疾病发病中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.05.0817

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (5): 817-821.doi: 10.16352/j.issn.1001-6325.2023.05.0817

组氨酸磷酸酶在某些疾病发病中作用的研究进展

国鸽, 刘春蕾^*

中国人民解放军总医院医学创新研究部转化医学研究中心,北京 100853

收稿日期:2021-12-17 修回日期:2022-06-29 出版日期:2023-05-05 发布日期:2023-04-26
通讯作者: ^*liuchunlei@plagh.org
基金资助:
国家自然科学基金(82101966)

Progress on the role of histidine phosphatase in the occurrence of some diseases

GUO Ge, LIU Chunlei^*

Translation Medicine Research Center, Medical Innovcation Research Division of Chinese People's Liberation Army General Hospital, Beijing 100853, China

Received:2021-12-17 Revised:2022-06-29 Online:2023-05-05 Published:2023-04-26
Contact: ^*liuchunlei@plagh.org

摘要/Abstract

摘要： 蛋白的磷酸化修饰参与调控多种生物学过程,组氨酸磷酸酶可以使含有磷酸化的组蛋白去磷酸化。组氨酸磷酸酶功能障碍会导致多种临床疾病的发生,如肿瘤、代谢性疾病等。本文分别从组氨酸磷酸酶的组成,组氨酸磷酸酶与临床疾病的联系进行简要综述,以期为疾病的预防和诊治提供新思路。

关键词: 组氨酸磷酸酶, 疾病

Abstract: Protein phosphorylation is involved in the regulation of a variety of biological processes. Histidine phosphatase dephosphorylates proteins containing histidine phosphorylation. Therefore, histidine phosphatase dysfunction can lead to the occurrence of a variety of clinical diseases, such as tumors, metabolic diseases, etc. This review summarizes the composition of histidine phosphatase, the relationship between histidine phosphatase and clinical diseases in orer to provide a new pathway for the clinical treatment of diseases.

Key words: histidine phosphatase, diseases

中图分类号:

R34
R730.2

国鸽, 刘春蕾. 组氨酸磷酸酶在某些疾病发病中作用的研究进展[J]. 基础医学与临床, 2023, 43(5): 817-821.

GUO Ge, LIU Chunlei. Progress on the role of histidine phosphatase in the occurrence of some diseases[J]. Basic & Clinical Medicine, 2023, 43(5): 817-821.

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组氨酸磷酸酶在某些疾病发病中作用的研究进展

Progress on the role of histidine phosphatase in the occurrence of some diseases

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