CircRNA在骨科疾病中的研究进展

doi:10.16352/j.issn.1001-6325.2025.03.0399

摘要/Abstract

摘要： 环状RNA(circRNAs)是一类由共价键首尾相连形成的闭合环状非编码RNA(ncRNAs)。CircRNAs通过调控细胞外基质的降解、软骨细胞的炎性反应和稳态参与骨关节炎的发生发展;调控骨髓间充质干细胞成骨分化、骨微血管内皮细胞的活性和血管生成影响股骨头坏死;调控骨髓干细胞、成骨细胞和破骨细胞分化导致骨质疏松症;通过不同机制影响骨肉瘤的侵袭、转移和耐药性。CircRNAs在未来有望成为一种新的临床诊断标志物。

关键词: 环状RNA, 骨科疾病, miRNA海绵

Abstract: Circular RNAs(circRNAs) are a class of closed-loop non-coding RNAs(ncRNAs) formed by head-to-tail covalent bonds. CircRNAs participate in the development of osteoarthritis by regulating extracellular matrix degradation, inflammatory response and homeostasis of chondrocytes; It regulates the osteogenic differentiation of bone marrow mesenchymal stem cells, the activity of bone microvascular endothelial cells and angiogenesis to affect femoral head necrosis; It regulates the differentiation of bone marrow stem cells, osteoblasts and osteoclasts to cause osteoporosis and it affects the invasion, metastasis and drug resistance of osteosarcoma through different pathogenesis. CircRNAs are expected to become a new clinical diagnostic marker in the future.

Key words: circular RNA, orthopedics diseases, miRNA sponge

中图分类号:

R681

吕树刚, 赵桐, 陈国良, 杜鑫, 王文己. CircRNA在骨科疾病中的研究进展[J]. 基础医学与临床, 2025, 45(3): 399-403.

LYU Shugang, ZHAO Tong, CHEN Guoliang, DU Xin, WANG Wenji. Advance of circRNA in the research on orthopedic diseases[J]. Basic & Clinical Medicine, 2025, 45(3): 399-403.

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