环状RNAs在前列腺癌中的研究进展

doi:10.16352/j.issn.1001-6325.2022.01.028

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (1): 179-183.doi: 10.16352/j.issn.1001-6325.2022.01.028

环状RNAs在前列腺癌中的研究进展

冯天瑞, 严维刚^*

中国医学科学院北京协和医学院北京协和医院泌尿外科,北京 100730

收稿日期:2020-09-07 修回日期:2021-05-31 出版日期:2022-01-05 发布日期:2022-01-05
通讯作者: ^* ywgpumch@sina.com
基金资助:
国家自然科学基金国家重大科研仪器研制项目(21527801)

Research progress of circular RNAs in prostate cancer

FENG Tian-rui, YAN Wei-gang^*

Departments of Urology,Peking Union Medical College Hospital,CAMS & PUMC,Beijing 100730,China

Received:2020-09-07 Revised:2021-05-31 Online:2022-01-05 Published:2022-01-05
Contact: ^* ywgpumch@sina.com

摘要/Abstract

摘要： 环状RNAs(circRNAs)是一类有着独特的共价闭合环状结构的非编码RNAs,其广泛存在于真核细胞中。近年来的研究表明circRNAs可通过调控microRNAs、与蛋白质结合、调节转录及剪接过程等方式参与包括恶性肿瘤在内的多种疾病的病理生理学过程。circRNAs特殊的结构和复杂的功能使其在肿瘤领域有着巨大的研究潜能。前列腺癌(PCa)是当今全球男性最高发的恶性肿瘤,目前对PCa发生的机制及其诊治方案仍有待进一步深入研究。

关键词: 环状RNA, 前列腺癌, 基因调控

Abstract: Circular RNAs (circRNAs) are non-coding RNAs with unique covalently closed circular structures and are widely found in eukaryotic cells. Recent studies have shown that circRNAs are involved in the patho-physiological processes of various diseases including malignant tumors through regulating microRNAs, binding to proteins and regulating transcription and splicing process. The special structure and complex functions of circRNAs make them have great research potential in the field of cancer. Prostate cancer(PCa) is one of the most common malignancies among the world. The the pathogenesis and treatment of PCa still need to be further studied.

Key words: circular RNAs, prostate cancer, gene regulation

中图分类号:

R737.25

冯天瑞, 严维刚. 环状RNAs在前列腺癌中的研究进展[J]. 基础医学与临床, 2022, 42(1): 179-183.

FENG Tian-rui, YAN Wei-gang. Research progress of circular RNAs in prostate cancer[J]. Basic & Clinical Medicine, 2022, 42(1): 179-183.

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环状RNAs在前列腺癌中的研究进展

Research progress of circular RNAs in prostate cancer

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