牙源性干细胞治疗帕金森病的研究进展

doi:10.16352/j.issn.1001-6325.2024.09.1298

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (9): 1298-1302.doi: 10.16352/j.issn.1001-6325.2024.09.1298

牙源性干细胞治疗帕金森病的研究进展

于曼殊¹, 赵晓敏¹, 邱明月², 刘春冉², 那日苏^2*

1.内蒙古医科大学赤峰临床医学院赤峰市医院, 内蒙古赤峰 024000;
2.赤峰市医院口腔科, 内蒙古赤峰 024000

收稿日期:2023-10-19 修回日期:2024-03-29 出版日期:2024-09-05 发布日期:2024-08-30
通讯作者: ^*nrsmail@163.com
基金资助:
内蒙古医科大学联合项目(YKD2023LH007);省公立医院科研联合基金科技项目(2023GLLH0321)

Advances in the treatment of dental stem cells for Parkinson′s disease

YU Manshu¹, ZHAO Xiaomin¹, QIU Mingyue², LIU Chunran², NA Risu^2*

1. Chifeng Clinical Medical College of Inner Mongolia Medical University, Chifeng Municipal Hospital, Chifeng 024000;
2. Department of Stomatology, Chifeng Municipal Hospital, Chifeng 024000, China

Received:2023-10-19 Revised:2024-03-29 Online:2024-09-05 Published:2024-08-30
Contact: ^*nrsmail@163.com

摘要/Abstract

摘要： 帕金森病(PD)是第二常见的神经退行性疾病,主要是由于中脑黑质 (SN)多巴胺能神经元的丧失而导致运动功能障碍。牙源性干细胞(DSCs)来自颅神经嵴,易于采集,具有很强的增殖和分化能力,能够促进神经修复和再生。DSCs可以分化成新的多巴胺神经元并分泌大量神经营养因子(NTFs)改善神经功能,同时还可以通过免疫调节抑制神经炎性反应,DSCs可以有效减轻PD大鼠的运动功能障碍,并在再生医学领域中扮演着重要的角色。

关键词: 牙髓干细胞, 人脱落乳牙干细胞, 神经退行性疾病, 帕金森病, 外泌体

Abstract: Parkinson′s disease (PD) is the second most common neurodegenerative disease, mainly due to the loss of dopaminergic neurons in the substantia nigra (SN) of the midbrain, resulting in motor dysfunction. Dental stem cells (DSCs) are derived from the cranial neural crest which can be easily harvested. DSCs coming from the cranial neural crest have excellent proliferation and differentiation ability, and can promote nerve repair and regeneration. DSCs can secrete new dopamine neurons and secrete a large number of neurotrophic factors(NTFs) to improve the neural function, and also inhibit the neuroinflammatory response through immune modulation. DSCs can effectively alleviate the motor dysfunction in rats with PD and play an important role in R&D of regenerative medicine.

Key words: dental pulp stem cell, stem cells from human exfoliated deciduous teeth, neurodegenerative disease, Parkinson ′s disease, exosome

中图分类号:

于曼殊, 赵晓敏, 邱明月, 刘春冉, 那日苏. 牙源性干细胞治疗帕金森病的研究进展[J]. 基础医学与临床, 2024, 44(9): 1298-1302.

YU Manshu, ZHAO Xiaomin, QIU Mingyue, LIU Chunran, NA Risu. Advances in the treatment of dental stem cells for Parkinson′s disease[J]. Basic & Clinical Medicine, 2024, 44(9): 1298-1302.

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牙源性干细胞治疗帕金森病的研究进展

Advances in the treatment of dental stem cells for Parkinson′s disease

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