肠道菌群在妊娠期糖尿病发病中作用的研究进展

doi:10.16352/j.issn.1001-6325.2022.03.016

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (3): 516-519.doi: 10.16352/j.issn.1001-6325.2022.03.016

肠道菌群在妊娠期糖尿病发病中作用的研究进展

胡贤良^1,2, 万燕¹, 冯霁^1*

1.南昌大学第二附属医院临床营养科, 江西南昌 330006;
2.南昌大学江西医学院研究生部, 江西南昌 330006

收稿日期:2020-11-19 修回日期:2021-04-15 出版日期:2022-03-05 发布日期:2022-03-04
通讯作者: ^* Fengji0003@163.com

Research progress of gut microbiota in the pathogenesis of gestational diabetes mellitus

HU Xian-liang^1,2, WAN Yan¹, FENG Ji^1*

1. Department of Clinical Nutrition,the Second Affiliated Hospital, Nanchang University, Nanchang 330006;
2. Department of Graduate, Jiangxi Medical College, Nanchang University, Nanchang 330006, China

Received:2020-11-19 Revised:2021-04-15 Online:2022-03-05 Published:2022-03-04
Contact: ^* Fengji0003@163.com

摘要/Abstract

摘要： 肠道菌群对引发妊娠期糖尿病(GDM)具有重要作用。肠道菌群通过对肠道黏膜屏障的破坏,释放代谢产物、引起脂肪因子和炎性因子的释放及影响肠道免疫功能等方式导致胰岛素抵抗及分泌水平下降,血糖稳态失衡,最终引发GDM。益生菌可以有效改善GDM患者的肠道菌群失调及血糖的紊乱,从而改善妊娠结局。

关键词: 肠道菌群, 妊娠期糖尿病, 炎性反应

Abstract: Gut microbiota has an important influence in the pathogenesis of gestational diabetes mellitus(GDM).Gut microbiota rises insulin resistance,hypoinsulinemia,the disorder of blood glucose resulted from damage of the gut membrane barriers and from releasing metabolite,adipokine and inflammatory factors and then interfere the gut immune functions, finally result in GDM. The probiotic intake can effectively improve the disorders of gut microbiota and blood glucose of GDM patients, furthermore improve the pregnancy outcomes.

Key words: gut microbiota, gestational diabetes mellitus, inflammation

中图分类号:

R589

胡贤良, 万燕, 冯霁. 肠道菌群在妊娠期糖尿病发病中作用的研究进展[J]. 基础医学与临床, 2022, 42(3): 516-519.

HU Xian-liang, WAN Yan, FENG Ji. Research progress of gut microbiota in the pathogenesis of gestational diabetes mellitus[J]. Basic & Clinical Medicine, 2022, 42(3): 516-519.

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肠道菌群在妊娠期糖尿病发病中作用的研究进展

Research progress of gut microbiota in the pathogenesis of gestational diabetes mellitus

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