疾病相关的肠道菌群微生态在肺损伤形成的机制研究

doi:10.16352/j.issn.1001-6325.2025.05.0681

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (5): 681-685.doi: 10.16352/j.issn.1001-6325.2025.05.0681

疾病相关的肠道菌群微生态在肺损伤形成的机制研究

朱倩梅¹, 李清扬², 车璐^1*, 黄宇光¹

中国医学科学院北京协和医学院 1.北京协和医院麻醉科; 2.临床医学专业(八年制),北京 100730

收稿日期:2024-10-22 修回日期:2024-12-31 出版日期:2025-05-05 发布日期:2025-04-23
通讯作者: ^* tracymaobao@126.com
基金资助:
北京协和医院中央高水平医院临床科研专项(022-PUMCH-B-006)

Disease-associated gut microbiota involvement and its mechanisms in the lung injury

ZHU Qianmei¹, LI Qingyang², CHE Lu^1*, HUANG Yuguang¹

1. Department of Anesthesiology, Peking Union Medical College Hospital; 2. Eight-year Medical Doctor Program, CAMS & PUMC, Beijing 100730, China

Received:2024-10-22 Revised:2024-12-31 Online:2025-05-05 Published:2025-04-23
Contact: ^* tracymaobao@126.com

摘要/Abstract

摘要： 肠道微生物群被普遍认为参与调节机体代谢和免疫功能,而肠道微生态失衡与肺损伤所致的急、慢性肺疾病的发生发展机制相关。“肠-肺轴”在肺损伤形成中以多种方式发挥重要作用,包括肠道屏障功能障碍、肠道菌群多样性降低、有益代谢产物分泌减少、肠道菌群和代谢物向肺部移位、机体和肺部免疫受损、肺部炎性反应增加等。

关键词: 肠道菌群, 肺损伤, 免疫, 围术期

Abstract: The gut microbiota is generally thought in regulating the body′s metabolism and immune function. The imbalance of gut microbiota is related to the occurrence and development mechanisms of acute and chronic lung diseases, resulting from lung injury. The “gut-lung axis” pays a main role in various ways in the occurrence of lung injury, including intestinal barrier dysfunction, reduced diversity of gut microbiota, decreased secretion of beneficial metabolites, translocation of gut microbiota and metabolites to the lungs, immune damage to the body and lungs, increased inflammatory response in the lungs.

Key words: gut microbiota, lung injury, immunity, perioperative

中图分类号:

朱倩梅, 李清扬, 车璐, 黄宇光. 疾病相关的肠道菌群微生态在肺损伤形成的机制研究[J]. 基础医学与临床, 2025, 45(5): 681-685.

ZHU Qianmei, LI Qingyang, CHE Lu, HUANG Yuguang. Disease-associated gut microbiota involvement and its mechanisms in the lung injury[J]. Basic & Clinical Medicine, 2025, 45(5): 681-685.

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疾病相关的肠道菌群微生态在肺损伤形成的机制研究

Disease-associated gut microbiota involvement and its mechanisms in the lung injury

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