关键词: 变应性支气管肺曲霉病, 复发, 半乳甘露聚糖, 烟曲霉特异性免疫球蛋白G, 烟曲霉特异性免疫球蛋白E

Abstract: Objective To explore the relationship between serum galactomannano (GM) level and specific antibody level of Aspergillus fumigatus in patients with allergic bronchopulmonary aspergillus (ABPA) recurrence. Methods A total of 124 patients diagnosed with ABPA and treated with hormone therapy in our hospital from June 2020 to June 2023 were retrospectively analyzed. According to the recurrence after treatment, the patients were divided into non-recurrence group (n=72) and recurrence group (n=52). The clinical data, blood routine indicators, GM and Aspergillus fumigatus specific antibody level of the two groups were recorded. Results Age, white blood cell(WBC),neutrophil(NEU), lymphocyte(LYM), eosinophil(EOS), GM, serum total immunoglobulin E(tIgE),Aspergillus fumigatus specific immunoglobulin E (sIgE) and Aspergillus fumigatus specific immunoglobulin G(sIgG) were higher in the recurrence group than in the non-recurrence group (P＜0.05). There was a nonlinear relationship between GM and sIgE/sIgG (P＜0.05). GM, sIgE and sIgG were independently correlated with the risk of ABPA recurrence (P＜0.05), and had a nonlinear dose-response relationship with the risk of ABPA recurrence (P_{for non linear}＜0.05). Under different GM level, the higher the sIgE and sIgG, the higher the ABPA recurrence rate. There was an interaction between GM and sIgE/ sIgG. Conclusions With the increase of GM, sIgE and sIgG level, the recurrence rate of ABPA increases. Serum GM level in ABPA recurrence patients is correlated with Aspergillus fumigatus specific antibody.

Key words: allergic bronchopulmonary aspergillosis, recurrence, galactomannan, Aspergillus specific immunoglobulin G, Aspergillus specific immunoglobulin E