中性粒细胞胞外诱捕网在脓毒症诱导的急性呼吸窘迫综合征中的研究进展

doi:10.16352/j.issn.1001-6325.2026.01.0139

基础医学与临床 ›› 2026, Vol. 46 ›› Issue (1): 139-143.doi: 10.16352/j.issn.1001-6325.2026.01.0139

中性粒细胞胞外诱捕网在脓毒症诱导的急性呼吸窘迫综合征中的研究进展

刘婷婷¹, 郜玲¹, 李筱妍^2*

1.山西医科大学第三医院山西白求恩医院山西医学科学院同济山西医院呼吸与危重症医学科,山西太原 030032;
2.上海市浦东新区周浦医院上海健康医学院附属周浦医院呼吸与危重症医学科,上海 201318

收稿日期:2025-02-27 修回日期:2025-04-29 出版日期:2026-01-05 发布日期:2025-12-29
通讯作者: ^*2415960869@qq.com
基金资助:
上海健康医学院附属周浦医院引进人才资助项目(ZP-XK-2023B-4)

Research progress on neutrophil extracellular traps in sepsis-induced acute respiratory distress syndrome

LIU Tingting¹, GAO Ling¹, LI Xiaoyan^2*

1. Department of Respiratory and Critical Care Medicine, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032;
2. Department of Pulmonary Critical Care Medicine, Shanghai Pudong New Area Zhoupu Hospital, the Affiliated Zhoupu Hospital of Shanghai University of Medicine & Health Sciences, Shanghai 201318, China

Received:2025-02-27 Revised:2025-04-29 Online:2026-01-05 Published:2025-12-29
Contact: ^*2415960869@qq.com

摘要/Abstract

摘要： 中性粒细胞胞外诱捕网(NETs)是由多形核中性粒细胞释放的染色质纤维构建的网状结构,主要由DNA、组蛋白和颗粒蛋白组成。NETs能够介导下游信号通路,从而激活炎性反应,导致肺组织损伤。并可激活凝血途径,促进微血栓形成,导致微循环障碍,进一步加剧肺组织的损伤。这些作用机制揭示了,NETs是脓毒症诱导的急性呼吸窘迫综合征(ARDS)进展的危险因素,抑制NETs的释放为延缓ARDS进展起着重要作用。

关键词: 中性粒细胞胞外诱捕网(NETs), 脓毒症, 急性呼吸窘迫综合征, 炎性反应

Abstract: Neutrophil extracellular traps(NETs) are networks made of chromatin fibers released from polymorph nuclear neutrophils, mainly composed of DNA, histones and granule proteins. NETs are able to mediate downstream signaling pathways, which can activate inflammatory responses, leading to lung tissue injury. And can activate the coagulation pathway, promote microthrombus formation, lead to microcirculation disorders, and further aggravate the damage of lung tissue. These mechanisms of action revealed that NETs are risk factors for sepsis-induced acute respiratory distress syndrome(ARDS) progression, and that inhibition of the release of NETs has an important role in the mechanisms of delaying ARDS progression.

Key words: neutrophil extracellular traps(NETs), sepsis, acute respiratory distress syndrome, inflammation

中图分类号:

R563

刘婷婷, 郜玲, 李筱妍. 中性粒细胞胞外诱捕网在脓毒症诱导的急性呼吸窘迫综合征中的研究进展[J]. 基础医学与临床, 2026, 46(1): 139-143.

LIU Tingting, GAO Ling, LI Xiaoyan. Research progress on neutrophil extracellular traps in sepsis-induced acute respiratory distress syndrome[J]. Basic & Clinical Medicine, 2026, 46(1): 139-143.

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中性粒细胞胞外诱捕网在脓毒症诱导的急性呼吸窘迫综合征中的研究进展

Research progress on neutrophil extracellular traps in sepsis-induced acute respiratory distress syndrome

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