Mechanism of Panax notoginseng saponins in the prevention of thrombosis

doi:10.16352/j.issn.1001-6325.2024.07.0912

Abstract

Abstract: Panax notoginseng saponins (PNSs) as the extracted bioactive components of Panax notoginseng, have a long history of application in prevention of thrombosis. PNSs down-regulate the expression of inflammatory factors, promoting endothelial cell growth, up-regulating the expression of anticoagulants and vasodilators, and regulating endothelial cell function; With multiple targets at which PNSs inhibit platelet adhesion, release, and aggregation; PNSs maintain the activity of the fibrinolytic system by regulating the dynamic balance of tissue type plasminogen activators and inhibitors; PNSs reduce blood viscosity, improve red blood cell indicators, and inhibit thrombosis through multiple pathways.

Key words: Panax notoginseng saponins, thrombosis, mechanism

CLC Number:

R654.3

LI Peijuan, WANG Chunmei, ZHAO Qian. Mechanism of Panax notoginseng saponins in the prevention of thrombosis[J]. Basic & Clinical Medicine, 2024, 44(7): 912-915.

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