Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (1): 12-20.doi: 10.16352/j.issn.1001-6325.2023.01.0012

• Invited Reviews: Basic Research and Clinical Translation of Adult Stem Cells • Previous Articles     Next Articles

Research progress of mesenchymal stem cells in the treatment of liver disease

ZHOU Jiahang, CHEN Junyao, CAO Hongcui*   

  1. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
  • Received:2022-07-13 Revised:2022-10-10 Published:2022-12-27
  • Contact: *hccao@zju.edu.cn

Abstract: Liver disease is a serious threat to human health. However, there is still no effective medical treatment for end-stage liver diseases such as cirrhosis and liver failure. Mesenchymal stem cells (MSCs) are expected to be used clinically for liver cirrhosis caused by various etiologies, acute-on-chronic liver failure, chronic liver failure, and complications post-liver transplantation by their multi-directional differentiation and immunomodulatory abilities. MSCs can directly differentiate into hepatocyte-like cells and indirectly secrete soluble factors to achieve goals such as antioxidant, anti-regulated cell death, anti-fibrosis, inhibiting inflammation, inhibiting immune response, etc., so to reduce liver damage and improve survival rate. A sound quality standard evaluation system and a more in-depth mechanism exploration are the prerequisites for MSCs to be used in the clinical treatment of liver diseases in the future.

Key words: liver disease, mesenchymal stem cells, clinical treatment, mechanism

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