Advances on the role of PTTG1 in the pathogenesis of tumors

doi:10.16352/j.issn.1001-6325.2023.09.1448

Abstract

Abstract: Pituitary tumor transforming gene 1(PTTG1) is an oncogene which isolated from the pituitary gland. PTTG1 was previously reported to bind and inhibit separase to affect sister chromatid separation and lead to chromosome aneuploidy, activate the DNA damage response pathway to induce p53-dependent senescence, and also transactivate some oncogenes and promote cell transformation and tumorigenesis in nude mice. It can also promote tumor growth and invasion by affecting Wnt/β-catenin, epithelial-mesenchymal transition(EMT), and TGFβ/SMAD3 pathways. This article provides ideas for the development of tumor therapeutic drugs targeting PTTG1.

Key words: pituitary tumor transforming gene 1(PTTG1), mechanism, tumor

CLC Number:

:R73

WU Nianping, HUANG Huili, ZHOU Kuaile, ZHOU Cefan, TANG Jingfeng. Advances on the role of PTTG1 in the pathogenesis of tumors[J]. Basic & Clinical Medicine, 2023, 43(9): 1448-1452.

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URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/10.16352/j.issn.1001-6325.2023.09.1448

http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2023/V43/I9/1448

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